公开(公告)号：AU4112900A

公开(公告)日：2000-11-14

申请号：AU4112900

申请日：2000-03-29

Applicant: BASF AG

Inventor： ZECHEL JOHANN-CHRISTIAN ,  KLING ANDREAS ,  GENESTE HERVE ,  LANGE UDO ,  LAUTERBACH ARNULF ,  GRAEF CLAUDIA ISABELLA ,  SUBKOWSKI THOMAS ,  SADOWSKI JENS ,  HORNBERGER WILFRIED

IPC: C07D239/36 ,  A61K31/505 ,  A61K45/00 ,  A61K45/06 ,  A61P3/14 ,  A61P7/02 ,  A61P9/10 ,  A61P9/12 ,  A61P13/12 ,  A61P17/02 ,  A61P17/06 ,  A61P19/08 ,  A61P19/10 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/00 ,  A61P35/00 ,  C07D239/34 ,  C07D239/60 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/14 ,  C07D417/12 ,  C07D417/14

Abstract: The invention relates to novel compounds which bind to integrin receptors, to their preparation, to their use as integrin receptor ligands and for treating diseases, to pharmaceutical preparations comprising these compounds, and to pharmaceutical preparations comprising at least one other active compound.

公开(公告)号：CA2317761A1

公开(公告)日：1999-07-29

申请号：CA2317761

申请日：1999-01-23

Applicant: BASF AG

Inventor： MACK HELMUT ,  HOFFKEN HANS WOLFGANG ,  SEITZ WERNER ,  HORNBERGER WILFRIED ,  BAUCKE DORIT ,  LANGE UDO

IPC: A61K38/00 ,  A61P1/18 ,  A61P7/02 ,  A61P11/06 ,  A61P17/04 ,  A61P19/02 ,  A61P27/16 ,  A61P29/00 ,  C07K5/06 ,  C07K5/065 ,  A61K38/05

Abstract: The invention relates to compounds of the formula A-B-D-E-F, in which A, B, D, E and F have the meanings given in the description, and to their production. These new compounds are suitable for producing medicines.

公开(公告)号：PL331330A1

公开(公告)日：1999-07-05

申请号：PL33133097

申请日：1997-07-14

Applicant: BASF AG

Inventor： MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  BALKENHOHL FRIEDHELM ,  LANGE UDO

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C12P17/10

Abstract: PCT No. PCT/EP97/03752 Sec. 371 Date Jan. 22, 1999 Sec. 102(e) Date Jan. 22, 1999 PCT Filed Jul. 14, 1997 PCT Pub. No. WO98/04523 PCT Pub. Date Feb. 5, 19983-Pyrroline-2-carboxylic acid derivatives of the formula I are prepared by eliminating the sulfonic acid residue, with the aid of a base, from a compound of the formula II

公开(公告)号：CZ9900311A3

公开(公告)日：1999-06-16

申请号：CZ31199

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  PFEIFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED GOLDENER

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083 ,  A61K38/02

CPC classification number: C07K5/0222 ,  A61K38/00 ,  C07D207/22 ,  C07D211/78 ,  Y02P20/55

公开(公告)号：ZA977239B

公开(公告)日：1999-02-15

申请号：ZA977239

申请日：1997-08-13

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K ,  A61K

Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.

公开(公告)号：ZA9707240B

公开(公告)日：1999-02-15

申请号：ZA9707240

申请日：1997-08-13

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083 ,  C07K ,  A61K ,  C07D

CPC classification number: C07K5/0222 ,  A61K38/00 ,  C07D207/22 ,  C07D211/78 ,  Y02P20/55

公开(公告)号：ZA9707239B

公开(公告)日：1999-02-15

申请号：ZA9707239

申请日：1997-08-13

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K ,  A61K

CPC classification number: C07K5/06078 ,  A61K38/00

公开(公告)号：NO990662D0

公开(公告)日：1999-02-12

申请号：NO990662

申请日：1999-02-12

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER ,  ZIERKE THOMAS ,  HOEFFKEN HANS WOLFGANG ,  HORNBERGER WILFRIED

IPC: A61K38/00 ,  A61K38/05 ,  A61P7/02 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  C07K5/06 ,  C07K5/062 ,  C07K5/065 ,  C07K

Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.

公开(公告)号：CA2263344A1

公开(公告)日：1998-02-19

申请号：CA2263344

申请日：1997-07-29

Applicant: BASF AG

Inventor： BAUCKE DORIT ,  LANGE UDO ,  MACK HELMUT ,  HORNBERGER WILFRIED ,  HOEFFKEN HANS WOLFGANG ,  PFEIFFER THOMAS ,  SEITZ WERNER ,  ZIERKE THOMAS

IPC: A61K31/40 ,  A61K31/44 ,  A61K38/00 ,  A61K38/05 ,  A61P1/18 ,  A61P7/02 ,  A61P11/02 ,  A61P11/06 ,  A61P17/00 ,  A61P19/02 ,  A61P29/00 ,  A61P43/00 ,  C07D207/22 ,  C07D211/78 ,  C07K5/00 ,  C07K5/02 ,  C07K5/083 ,  C07K5/062 ,  C07K5/065

Abstract: Disclosed are compounds having formula (I) wherein the radicals R, R1, R2, R3, R4, R5 and R6, as well as l, m, and n have the meaning indicated in the description, and the production of said compounds. The new compounds can be used to combat illness. Also described are compounds having formula (II) wherein the radicals R, R1, R2, R3, R4, R5 and R6, as well as l, m, and n have the meaning indicated in claim 1, and compounds having formula (III) wherein l and R have the meaning indicated in claim 1 and Y is an N protective group, or N-terminal protected or unprotected amino acid or represents H.

公开(公告)号：CA2261628A1

公开(公告)日：1998-02-05

申请号：CA2261628

申请日：1997-07-14

Applicant: BASF AG

Inventor： PFEIFFER THOMAS ,  ZIERKE THOMAS ,  BALKENHOHL FRIEDHELM ,  LANGE UDO ,  MACK HELMUT ,  SEITZ WERNER

IPC: C12P17/04 ,  C07D207/22 ,  C07D401/12 ,  C12P17/10 ,  C12P41/00 ,  C07D403/12

Abstract: A process is disclosed for preparing 3-pyrroline-2-carboxylic acid derivatives of formula (I), in which R1 stands for H, C1-C6-alkyl, benzyl, benzyl substituted at the phenyl radical, allyloxycarbonyl, C1-C6-alkyloxycarbonyl, benzyloxycarbonyl, in which the benzyl radical can be substituted by OCH3 radicals, or for C1-C4-alkylcarbonyl; or R1 stands for an amino acid radical which can be alkylated or acylated at the nitrogen and is linked by the Cterminal; and R2 stands for OH, C1-C4-alkyloxy, benzyloxy or an N3R4 group, in which R3 and R4 represent independently from each other H, C1-C4-alkyl, benzyl, phenyl or pyridyl, in which the aromatic compounds in R3 and R4 can be substituted by up to three identical or different substituents selected from the group composed of methyl, methoxy, hydroxy, cyano or halogen. According to this process, the sulphonic acid radical is eliminated by means of a base from a compound having the formula (II), in which R1 and R2 have the above meanings and R5 stands for C1-C6-alkyl, benzyl, trifluoromethyl, naphthyl or phenyl optionally substituted by radicals from the group composed of methyl, nitro and halogen.