公开(公告)号：AU2003279785A1

公开(公告)日：2004-05-04

申请号：AU2003279785

申请日：2003-10-02

Applicant: BAXTER INT

Inventor： WONG JOSEPH CHUNG TAK ,  KIPP JAMES E ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  PAPADOPOULOS PAVLOS

IPC: A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K9/50 ,  A61K31/495 ,  A61K31/496

Abstract: The present invention relates to compositions of submicron-to micron-size particles of antifungal agents. More particularly the invention relates to aqueous suspensions of antifungal agents for pharmaceutical use.

公开(公告)号：HU0304086A2

公开(公告)日：2004-04-28

申请号：HU0304086

申请日：2002-03-28

Applicant: BAXTER INT

Inventor： DOTY MARK J ,  KIPP JAMES E ,  RAGHAVAN NEERVALUR ,  REBBECK CHRISTINE L

IPC: C07D307/80 ,  A61K9/00 ,  A61K9/08 ,  A61K31/343 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61P9/06

公开(公告)号：CA2461349A1

公开(公告)日：2003-04-03

申请号：CA2461349

申请日：2002-09-25

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  DUNHAM ANDREW J ,  DOTY MARK J ,  NARAYANAN KRISHNASWAMY ,  STERNBERG SHMUEL ,  JAYSWAL NAILESH ,  BRYNJELSEN SEAN

IPC: A61K9/14 ,  A61K9/19 ,  A61K9/51 ,  A61K31/496 ,  A61K45/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  B01J13/04

Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by sonicating to evaporate a portion of the organic phase or by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueou s phase, the organic phase havingthe poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo deliver y, particularly by parenteral routes.

公开(公告)号：CA2442365A1

公开(公告)日：2002-10-10

申请号：CA2442365

申请日：2002-03-28

Applicant: BAXTER INT

Inventor： RAGHAVAN NEERVALUR V ,  KIPP JAMES E ,  DOTY MARK J ,  REBBECK CHRISTINE L

IPC: C07D307/80 ,  A61K9/00 ,  A61K9/08 ,  A61K31/343 ,  A61K47/02 ,  A61K47/10 ,  A61K47/18 ,  A61K47/26 ,  A61K47/34 ,  A61K47/36 ,  A61P9/06

Abstract: A premix parenteral solution for intravenous administration having amiodarone, as an active ingredient, solubilized in a solution of water for injection and about 0.4 - 12 mg/ml of a non-ionic surfactant to a concentration range of from 0.2 to 6 mg/ml is disclosed. The solution optionally may include an osmotic agent. No dilution of the solution is required before administering to a patient and the sterile packaged solution has an initial pH within the range of from about 2.9 to about 3.2, preferably about 3.1. Additionally, a method for producing an amiodarone solution suitable for intravenous administration is further disclosed.

公开(公告)号：CA2404298A1

公开(公告)日：2001-10-11

申请号：CA2404298

申请日：2001-03-30

Applicant: BAXTER INT

Inventor： REBBECK CHRISTINE L ,  KIPP JAMES E ,  EILERT JAN Y ,  DOTY MARK J

IPC: A61K9/08 ,  A61K9/00 ,  A61K31/34 ,  A61K31/343 ,  A61K47/04 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61P9/06

Abstract: The present invention provides an amiodarone parenteral solution suitable fo r intravenous administration without the necessity of dilution. The parenteral solution has an amiodarone concentration from 0.2 to 10 mg/ml and a buffer solution selected from the group consisting of lactate buffer, methanesulfonate buffer, or combinations thereof, the solution having a pH within the range from approximately 2.5 - 4.5.

公开(公告)号：CA2461349C

公开(公告)日：2011-11-29

申请号：CA2461349

申请日：2002-09-25

Applicant: BAXTER INT

Inventor： BRYNJELSEN SEAN ,  STERNBERG SHMUEL ,  DUNHAM ANDREW J ,  DOTY MARK J ,  KIPP JAMES E ,  JAYSWAL NAILESH ,  NARAYANAN KRISHNASWAMY

IPC: A61K9/14 ,  A61K9/51 ,  A61K9/19 ,  A61K31/496 ,  A61K45/00 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/18 ,  A61K47/20 ,  A61K47/24 ,  A61K47/28 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  B01J13/04

Abstract: The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by sonicating to evaporate a portion of the organic phase or by lyophilizing a dispersion or microdispersion of a multiphase system having an organic phase and an aqueous phase, the organic phase havingthe poorly water soluble organic compound therein. The method is preferably used to prepare nanoparticles of a poorly water soluble, pharmaceutically active compound suitable for in vivo delivery, particularly by parenteral routes.

公开(公告)号：ES2340261T3

公开(公告)日：2010-06-01

申请号：ES02773797

申请日：2002-10-18

Applicant: BAXTER INT

Inventor： KIPP JAMES E ,  DOTY MARK J ,  REBBECK CHRISTINE L ,  BRYNJELSEN SEAN ,  KONKEL JAMIE TERESA

IPC: A61K9/10 ,  A61K8/02 ,  A61K8/04 ,  A61K8/06 ,  A61K8/34 ,  A61K8/35 ,  A61K8/36 ,  A61K8/365 ,  A61K8/37 ,  A61K8/39 ,  A61K8/40 ,  A61K8/41 ,  A61K8/44 ,  A61K8/46 ,  A61K8/60 ,  A61K8/64 ,  A61K8/73 ,  A61K8/86 ,  A61K8/89 ,  A61K8/891 ,  A61K9/107 ,  A61K9/14 ,  A61K31/12 ,  A61K31/4985 ,  A61K31/58 ,  A61K47/02 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/14 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61K47/26 ,  A61K47/32 ,  A61K47/34 ,  A61K47/36 ,  A61K47/38 ,  A61K47/42 ,  A61K47/44 ,  A61K47/46 ,  A61Q19/00

Abstract: Composición de una suspensión de un agente farmacéutico orgánico poco soluble en agua que comprende partículas del compuesto y un excipiente en una cantidad del 0,001% al 20% con respecto al peso total de la composición suspendida en una matriz acuosa congelada, caracterizada porque el excipiente incluye dos o más modificadores superficiales seleccionados de entre agentes tensioactivos aniónicos, agentes tensioactivos catiónicos, agentes tensioactivos no iónicos y modificadores biológicos activos superficiales, donde los modificadores biológicos activos superficiales se seleccionan de entre el grupo consistente en albúmina, caseína, heparina, hirudina u otras proteínas, y caracterizada porque más del 99% aproximadamente de las partículas tiene un tamaño de partícula inferior a 5 micras.

公开(公告)号：BRPI0519712A2

公开(公告)日：2009-03-10

申请号：BRPI0519712

申请日：2005-12-15

Applicant: BAXTER HEALTHCARE SA ,  BAXTER INT

Inventor： KIPP JAMES E ,  HAI TON THAT ,  MELNICK BENNETT P

IPC: C08G65/326 ,  C08G65/334 ,  C08L71/02

公开(公告)号：ZA200610078B

公开(公告)日：2008-06-25

申请号：ZA200610078

申请日：2006-12-01

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： KIPP JAMES E ,  RABINOW BARRETT E

IPC: A61K20090101 ,  A61K9/14 ,  A61K35/12 ,  A61K45/00 ,  A61K47/48 ,  A61K49/00 ,  C12N20090101 ,  C12N5/06

Abstract: The present invention is concerned with a method of preparing and delivering small particles of a pharmaceutically active material to a mammalian subject for treating diseases or disorders. A preferred embodiment entails: (i) the collection of tissue cells from an animal donor, (ii) selective or non-selective growth of these cells in a cell culture medium to which is added solid particles of a therapeutically active compound, mostly free of a drug carrier (about 10% or less, by weight), and having an average particle size of less than about 100 microns, (iii) contacting the cells in the cell culture medium with the solid particles of therapeutically active compound causing the particles to be taken up by the cells into either the intracellular compartment of the cultured cells, attachment of the active compound as particles to the periphery of such cells, or a combination of intracellular uptake and attachment to the cell surface, (iv) optionally, isolation and/or resuspension of the cells prepared in steps i through iii, (v) administering the cells to the mammalian subject. The pharmaceutically active material can be administered intravenously, intramuscularly, subcutaneously, intradermally, intra-articularly, intrathecally, epidurally, intracerebrally, via buccal route, rectally, topically, transdermally, orally, intranasally, via pulmonary route, intraperitoneally, or combinations thereof. After administration, the loaded cells transport the pharmaceutical composition as particles.

公开(公告)号：ZA200606051B

公开(公告)日：2008-04-30

申请号：ZA200606051

申请日：2006-07-21

Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

Inventor： JANE WERLING ,  CHAUBAL MAHESH V ,  KIPP JAMES E ,  RABINOW BARRETT E

IPC: A61K20090101 ,  A61K9/10 ,  A61K9/14 ,  A61K9/51 ,  A61K31/00 ,  A61K31/551 ,  A61K31/7072 ,  A61K31/7076

Abstract: The present invention provides compositions comprising dispersions of anti-retroviral agents and methods of manufacture. The nanosuspensions are made by the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation-homogenization.