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公开(公告)号：US20220160264A1
公开(公告)日：2022-05-26
申请号：US17489610
申请日：2021-09-29
Inventor： Axel SCHERER , Meisam Honarvar NAZARI , Muhammad MUJEEB-U-RAHMAN , Mehmet SENCAN , Arti GAUR
IPC: A61B5/1473 , A61B5/145 , A61B5/00 , A61B5/1459 , A61B5/07 , A61B5/1486 , A61B17/34 , A61M5/142 , A61M5/172
Abstract: A fully integrated small size implantable sensing device is described, which can include a sensor and an electronic circuit to interface with the sensor and communicate with an external device. Various fabrication methods for the sensing device are described, including provision of wells, created using same fabrication technology as the electronic circuit, to contain electrodes of the sensor and corresponding functionalization chemicals. Such implantable sensing device can be used for a variety of electrochemical measuring applications within a living body as well as actuation by injecting a current into the living body.
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公开(公告)号：US20220071529A1
公开(公告)日：2022-03-10
申请号：US17405943
申请日：2021-08-18
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Dvin ADALIAN , Samson CHEN , Muhammad M. JILANI , Axel SCHERER , Xiomara Linnette MADERO , Richard SMITH
IPC: A61B5/1486 , A61B5/145 , A61B5/1473
Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
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公开(公告)号：US20210093233A1
公开(公告)日：2021-04-01
申请号：US17037207
申请日：2020-09-29
Inventor： Axel SCHERER , Arti GAUR
IPC: A61B5/1473 , A61B5/145 , A61B5/00 , A61B5/1459 , A61B5/07 , A61B5/1486 , A61B17/34 , A61M5/142 , A61M5/172
Abstract: Wireless electrochemical measurements methods using minimally invasive micro-sensors that monitor response of cells to specific analytes are described. Micro-actuators integrated on a same chip as the micro-sensors are used to provide closed loop in-vivo local therapy on demand. An in-vivo bio-electronic system that can monitor the health of cell colonies and accordingly dispense corresponding therapeutic drugs is also described.
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公开(公告)号：US20190307378A1
公开(公告)日：2019-10-10
申请号：US16191357
申请日：2018-11-14
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Dvin ADALIAN , Samson CHEN , Muhammad M. JILANI , Axel SCHERER , Xiomara Linnette MADERO , Richard SMITH
IPC: A61B5/1486 , A61B5/145
Abstract: Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.
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公开(公告)号：US20180340826A1
公开(公告)日：2018-11-29
申请号：US15990114
申请日：2018-05-25
Applicant: California Institute of Technology
Inventor： Axel SCHERER , Taeyoon JEON
Abstract: A Fabry-Perot cavity-based spectral notch filter is disclosed, where the filter is operative for providing an output optical signal whose spectral content is spatially dispersed along at least one direction, while also controlling the spectral position and spectral range of the output light. In some embodiments, the spectral filter is integrated with a detector arrays to realize a compact, high-resolution spectrometer that can rapidly acquire the absorption spectrum of a sample with high sensitivity.
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Patent Agency Ranking
公开(公告)号：US20150321195A1
公开(公告)日：2015-11-12
申请号：US14697507
申请日：2015-04-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Axel SCHERER
CPC classification number: B01L7/52 , B01L3/5027 , B01L3/502715 , B01L7/5255 , B01L2200/147 , B01L2300/0654 , B01L2300/0829 , B01L2300/1805 , B01L2300/1883 , C12Q1/6851 , F28D2021/0077 , F28F13/00 , F28F2013/008 , G01N21/6428 , C12Q2565/629 , C12Q2561/113 , C12Q2527/101
Abstract: Temperature control devices and methods are described. The described temperature control devices and methods comprise optical emission and detection assemblies and can be used in PCR and qPCR applications.
Abstract translation: 描述温度控制装置和方法。 所描述的温度控制装置和方法包括光发射和检测组件，并且可以用于PCR和qPCR应用中。
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97.发明申请METHODS OF MODULATING MICROLASERS AT ULTRALOW POWER LEVELS, AND SYSTEMS THEREOF 有权在超低功率电平下调制微型电容器的方法及其系统公开(公告)号：US20150222073A1
公开(公告)日：2015-08-06
申请号：US14684280
申请日：2015-04-10
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Seheon KIM , Axel SCHERER , Aditya RAJAGOPAL , Chieh-Feng CHANG
CPC classification number: H01S3/0627 , A61B5/1459 , H01S3/025 , H01S3/091 , H01S3/102 , H01S3/1028 , H01S3/105 , H01S3/115 , H01S5/0607 , H01S5/0612 , H01S5/1042 , H01S5/3013
Abstract: A microlaser system includes an optical source, a microlaser, an actuator switch, and a photovoltaic power source. The microlaser, which includes a control element, is optically pumped by at least a portion of light emitted by the optical source. The actuator switch is configured to be activated by a triggering event. Furthermore, the photovoltaic power source is coupled in a series connection with the actuator switch and the control element, the series connection configured to connect the photovoltaic power source to the control element of the microlaser when the actuator switch is activated by the triggering event.
Abstract translation: 微型激光系统包括光源，微激光器，致动器开关和光伏电源。 包括控制元件的微激光器被由光源发射的光的至少一部分光泵浦。 执行器开关被配置为由触发事件激活。 此外，光伏电源与致动器开关和控制元件串联连接，串联连接被配置为当致动器开关被触发事件激活时将光伏电源连接到微型激光器的控制元件。
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公开(公告)号：US20150167092A1
公开(公告)日：2015-06-18
申请号：US14633094
申请日：2015-02-26
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Emil P. KARTALOV , Aditya RAJAGOPAL , Axel SCHERER , Mark D. GOLDBERG
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q1/68 , C12Q1/6851 , C12Q1/701 , C12Q1/703 , C12Q2600/156 , Y10T436/143333 , C12Q2561/113 , C12Q2565/101 , C12Q2527/101 , C12Q2565/1015 , C12Q2565/133
Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Förster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
Abstract translation: 描述了基于FRET的分析物检测和相关方法和系统，其中使用一对FRET标记的引物和/或寡核苷酸，其特异于靶向序列，其位于与FRET上呈现的FRET发色团的Förster距离的四倍 在一个或多个多核苷酸分析物中相对于另一个标记的引物和/或寡核苷酸; 特别地，一对FRET标记的引物和/或寡核苷酸与样品组合，并在测量来自至少一种FRET生色团的FRET信号之前进行一个或多个多核苷酸扩增反应。
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99.发明申请METHODS FOR FABRICATING HIGH ASPECT RATIO PROBES AND DEFORMING HIGH ASPECT RATIO NANOPILLARS AND MICROPILLARS 有权用于制备高倍率比例探针和改变高度比例的纳米颗粒和微孔的方法公开(公告)号：US20150050746A1
公开(公告)日：2015-02-19
申请号：US14527039
申请日：2014-10-29
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Michael D. HENRY , Andrew P. HOMYK , Axel SCHERER , Thomas A. TOMBRELLO , Sameer WALAVALKAR
IPC: G01N1/40
CPC classification number: B81C1/00111 , B01J19/0046 , B01J2219/00504 , B01J2219/00664 , B81B1/006 , B81B2203/0361 , B81B2207/056 , B81C2201/0112 , B81C2201/0132 , B81C2201/0133 , B81C2201/0159 , G01N1/405 , H01L21/3065 , H01L21/30655 , H01L21/3081 , H01L21/3086 , Y10T436/25375
Abstract: Methods for fabricating of high aspect ratio probes and deforming micropillars and nanopillars are described. Use of polymers in deforming nanopillars and micropillars is also described.
Abstract translation: 描述了制造高纵横比探针和变形微柱和纳米柱的方法。 还描述了聚合物在变形纳米柱和微柱体中的使用。
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公开(公告)号：US20150024481A1
公开(公告)日：2015-01-22
申请号：US14483605
申请日：2014-09-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Imran R. MALIK , Axel SCHERER
IPC: B01L3/00
CPC classification number: B01L3/502784 , B01L3/502 , B01L3/502715 , B01L3/502753 , B01L3/502776 , B01L7/52 , B01L2200/0621 , B01L2200/10 , B01L2300/0681 , B01L2300/0867 , B01L2300/087 , B01L2300/165 , B01L2400/0478 , B01L2400/0481 , B01L2400/0487 , B01L2400/0644 , C12Q1/68 , F17D3/00 , G01N35/1097 , G01N2001/4088 , Y10T137/0318 , Y10T137/8593 , Y10T137/85978
Abstract: Devices and system for preparing samples are described. Such devices can comprise fluidic chambers, reservoirs, and movable structures for controlling the movement of samples. The device can also comprise functional elements for performing specific operations.
Abstract translation: 描述用于制备样品的装置和系统。 这种装置可以包括用于控制样品运动的流体室，储存器和可移动结构。 该装置还可以包括用于执行特定操作的功能元件。
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