公开(公告)号：NO179614B

公开(公告)日：1996-08-05

申请号：NO905521

申请日：1990-12-20

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  MEICHSNER CHRISTOPH

IPC: A61K31/66 ,  A61K31/662 ,  A61K31/675 ,  A61K31/685 ,  A61P31/12 ,  A61P31/18 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/6558 ,  C07F9/6571

Abstract: The compound of the formula I in which R represents an aldehyde group or a group which can be converted into an aldehyde, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesium, aluminium, lithium, ammonium or triethylammonium or R and R together form a cyclic diester, R and R represent alkyl, alkenyl, alkynyl, cycloalkyl, hydrogen, alkoxy or halogen, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, X, Y or Z represent oxygen or sulphur, or prodrug forms of the compound of the formula I can be used for treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations which contain them and also their use are described.

公开(公告)号：IE67439B1

公开(公告)日：1996-04-03

申请号：IE462590

申请日：1990-12-20

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  WINKLER IRVIN ,  HELSBERG MATTHIAS ,  MEICHSNER CHRISTOPH

IPC: A61K31/66 ,  A61K31/662 ,  A61K31/675 ,  A61K31/685 ,  A61P31/12 ,  A61P31/18 ,  C07F9/38 ,  C07F9/40 ,  C07F9/58 ,  C07F9/653 ,  C07F9/6539 ,  C07F9/6558 ,  C07F9/6571

Abstract: The compound of the formula I in which R represents an aldehyde group or a group which can be converted into an aldehyde, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, hydrogen, sodium, potassium, calcium, magnesium, aluminium, lithium, ammonium or triethylammonium or R and R together form a cyclic diester, R and R represent alkyl, alkenyl, alkynyl, cycloalkyl, hydrogen, alkoxy or halogen, R and R represent alkyl, alkenyl, alkynyl, aralkyl, cycloalkyl, alkoxy, phenyl, cyanide, hydroxyl or hydrogen, X, Y or Z represent oxygen or sulphur, or prodrug forms of the compound of the formula I can be used for treatment of diseases caused by viruses. The preparation of these compounds and pharmaceutical preparations which contain them and also their use are described.

公开(公告)号：SI9500260A

公开(公告)日：1996-02-29

申请号：SI9500260

申请日：1995-08-16

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JOERG-PETER ,  RIESS GUENTHER ,  ROESNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/24 ,  C07D215/26 ,  C07D215/36 ,  C07D215/38 ,  C07D215/58 ,  C07D221/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D215/18 ,  C07D401/00

Abstract: 4-Methylene-2-quinolones of formula (I) and their tautomers of formula (Ia) and their isomers, salts and prodrugs are new: n = 0-4; R1 = halo, CF3, OCF3, OH, alkyl, cycloalkyl, alkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, NO2, NH2, azido, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidino, acyl, acyloxy, acylamino, CONH2, COOH, alkoxycarbonyl, SO3H, SO2NH2, Ar, OAr, COOAr, SAr, SOAr, SO2Ar, SO3Ar, OSO2Ar, SO2NHAr, NHSO2Ar, COAr, Ar', etc.; Ar,Ar' = phenyl and heteroaryl resp., etc.; X = O, S, Se, NR2 or NOR2; R2 = H; alkyl opt. substd. by halogen, CN, NH2, OH, etc.;R5, R6 = COOH or gps. as defined for R2; or R5+R6 forms a 3-8C carbocyclic ring; R3,R4 = alkyl, alkenyl, cycloalkyl or cycloalkenyl,etc.; or R3+R4 = a 3-8C carbocyclic ring; or R3+R4 = CZ1Z2 gp., where Z1 and Z2 are as defined for R3 and R4 as above; provided that X is not O when R1=R2=R5=R6=H and R3=R4=Me or R3+R4= (CH2)4.

公开(公告)号：CA2156128A1

公开(公告)日：1996-02-17

申请号：CA2156128

申请日：1995-08-15

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JOERG-PETER ,  RIEBETA GUENTHER ,  ROESNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/24 ,  C07D215/26 ,  C07D215/36 ,  C07D215/38 ,  C07D215/58 ,  C07D221/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D215/16 ,  C07D401/00 ,  C07D405/00 ,  C07D409/00 ,  C07D413/00 ,  C07D417/00 ,  A61K31/505 ,  A61K31/535

Abstract: Compounds of the formula I, (I) and also their tautomeric forms of the formula Ia, (Ia) in which the substituents R1 to R6 and X have said meanings, exhibit antiviral activity.

公开(公告)号：NZ245720A

公开(公告)日：1995-12-21

申请号：NZ24572093

申请日：1993-01-20

Applicant: HOECHST AG

Inventor： UHLMANN EUGEN ,  PEYMAN ANUSCHIRWAN ,  O'MALLEY GERARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN

IPC: A61K31/70 ,  A61K31/7125 ,  A61K48/00 ,  A61P31/12 ,  A61P35/00 ,  C07F9/22 ,  C07F9/24 ,  C07H1/00 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/68 ,  C07H19/00 ,  C07F9/02

Abstract: The invention relates to compounds of the formula I in which R is H, alkyl, acyl, aryl or a phosphate residue; R is H, OH, alkoxy, NH2 or halogen; B is a base customary in nucleotide chemistry; a is O or CH2; n is an integer from 1 to 100; W is O, S or Se; V is O, S or NH; Y is O, S, NH or CH2; Y' is O, S, NH or alkylene; X is OH or SH; U is OH, SH, SeH, alkyl, aryl or amine, and Z is OH, SH, SeH, an optionally substituted radical from the series comprising alkyl, aryl, heteroaryl, alkoxy or amino or a group which favours intracellular uptake or as labelling of a DNA probe or which on hybridisation interacts with the target nucleic acid, where if Z is OH, SH, CH3 or OC2H5, at least one of the groups X, Y, Y', V, W is not equal to OH or O, or R is not equal to H; process for their preparation and their use as inhibitors of gene expression, as probes for detecting nucleic acids and as aids in molecular biology.

公开(公告)号：HU9502403D0

公开(公告)日：1995-10-30

申请号：HU9502403

申请日：1995-08-15

Applicant: HOECHST AG

Inventor： KIRSCH REINHARD ,  KLEIM JOERG-PETER ,  RIESS GUENTHER ,  ROESNER MANFRED ,  WINKLER IRVIN

IPC: A61K31/47 ,  A61P31/12 ,  A61P31/18 ,  C07D215/22 ,  C07D215/227 ,  C07D215/24 ,  C07D215/26 ,  C07D215/36 ,  C07D215/38 ,  C07D215/58 ,  C07D221/20 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14

Abstract: 4-Methylene-2-quinolones of formula (I) and their tautomers of formula (Ia) and their isomers, salts and prodrugs are new: n = 0-4; R1 = halo, CF3, OCF3, OH, alkyl, cycloalkyl, alkoxy, alkoxyalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, NO2, NH2, azido, alkylamino, dialkylamino, piperidino, morpholino, pyrrolidino, acyl, acyloxy, acylamino, CONH2, COOH, alkoxycarbonyl, SO3H, SO2NH2, Ar, OAr, COOAr, SAr, SOAr, SO2Ar, SO3Ar, OSO2Ar, SO2NHAr, NHSO2Ar, COAr, Ar', etc.; Ar,Ar' = phenyl and heteroaryl resp., etc.; X = O, S, Se, NR2 or NOR2; R2 = H; alkyl opt. substd. by halogen, CN, NH2, OH, etc.;R5, R6 = COOH or gps. as defined for R2; or R5+R6 forms a 3-8C carbocyclic ring; R3,R4 = alkyl, alkenyl, cycloalkyl or cycloalkenyl,etc.; or R3+R4 = a 3-8C carbocyclic ring; or R3+R4 = CZ1Z2 gp., where Z1 and Z2 are as defined for R3 and R4 as above; provided that X is not O when R1=R2=R5=R6=H and R3=R4=Me or R3+R4= (CH2)4.

公开(公告)号：NO945094L

公开(公告)日：1995-07-03

申请号：NO945094

申请日：1994-12-30

Applicant: HOECHST AG

Inventor： WIRTH KLAUS ,  WINKLER IRVIN ,  LEMBECK FRED ,  BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN

IPC: A61K38/04 ,  A61K38/17 ,  A61K38/08 ,  A61P31/12

Abstract: Bradykinin antagonists and the physiologically tolerated salts thereof are suitable for the treatment or prophylaxis of viral diseases.

公开(公告)号：FI950010A

公开(公告)日：1995-07-01

申请号：FI950010

申请日：1995-01-02

Applicant: HOECHST AG

Inventor： WIRTH KLAUS ,  WINKLER IRVIN ,  LEMBECK FRED ,  BREIPOHL GERHARD ,  HENKE STEPHAN ,  KNOLLE JOCHEN

IPC: A61K38/04 ,  A61K38/17 ,  A61K38/08 ,  A61P31/12 ,  A61K

Abstract: Bradykinin antagonists and the physiologically tolerated salts thereof are suitable for the treatment or prophylaxis of viral diseases.

公开(公告)号：CA2135591A1

公开(公告)日：1995-05-13

申请号：CA2135591

申请日：1994-11-10

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  MAG MATTHIAS ,  KRETZSCHMAR GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN

IPC: C12N15/09 ,  A61K31/70 ,  A61K31/7088 ,  A61P31/12 ,  A61P31/22 ,  A61P35/00 ,  C07H21/00 ,  C07H21/04 ,  C12Q1/70 ,  C12Q1/68

Abstract: of the disclosure: Stabilized oligonucleotides and their use The invention relates to novel stabilized oligonucleotides in which at least one non-terminal pyrimidine nucleoside is modified, and to their use as a diagnostic or pharmaceutical for the treatment of viral infections, cancer or diseases in which integrins or cell-cell adhesion receptors are active.

公开(公告)号：CA2132265A1

公开(公告)日：1995-03-18

申请号：CA2132265

申请日：1994-09-16

Applicant: HOECHST AG

Inventor： PEYMAN ANUSCHIRWAN ,  UHLMANN EUGEN ,  MAG MATTHIAS ,  KRETZSCHMAR GERHARD ,  HELSBERG MATTHIAS ,  WINKLER IRVIN

IPC: C12N15/09 ,  A61K31/70 ,  A61P31/12 ,  A61P31/22 ,  C07H21/00 ,  C07H21/04 ,  C12N15/113 ,  A61K48/00 ,  A61K47/48

Abstract: of the disclosure Novel antisense oligonucleotides against HSV 1, and their preparation The invention relates to novel antisense oligonucleotides having the sequences AO1 (Herp099): 5'-G C G G G G C T C C A T G G G G G T C G-3' AO2 (Herp018): 5'-G C A G G A G G A T G C T G A G G A G G-3' AO3 (Herp002): 5'-G G G G C G G G G C T C C A T G G G G G-3' AO4 (Herp112): 5'-G G C G G G G C T C C A T G G G G G T C-3' AO5 (Herp034): 5'-G G G G C T C C A T G G G G G T C G T A-3' AO6 (Herp024): 5'-A A G A G G T C C A T T G G G T G G G G-3' or AO7 (Herp028): 5'-G G C C C T G C T G T T C C G T G G C G-3' and their mixtures, homologs or modified forms, against HSV 1.