公开(公告)号：FR2854634A1

公开(公告)日：2004-11-12

申请号：FR0305448

申请日：2003-05-05

Applicant: SERVIER LAB

Inventor： GRAINDORGE EMMANUEL ,  FRANCOTTE PIERRE ,  BOVERIE STEPHANE ,  DE TULLIO PASCAL ,  PIROTTE BERNARD ,  LESTAGE PIERRE ,  DANOBER LAURENCE ,  RENARD PIERRE ,  CAIGNARD DANIEL HENRI

IPC: A61P25/18 ,  C07D513/04 ,  A61K31/549

Abstract: Compounds of formula (I): wherein: A represents thienyl, furyl, pyrrolyl, oxathiol, thiazole, isothiazole, oxazole or imidazole, represents a single bond or a double bond, R1 represents hydrogen, linear or branched (C1-C6)alkyl optionally substituted by one or more groups selected from halogen or (C1-C6)alkoxy-(C1-C6)alkyl, R2 represents hydrogen or linear or branched (C1-C6)alkyl group optionally substituted by one or more halogen, R3 represents hydrogen or a group selected from linear or branched (C1-C6)alkyl, CONHR' and SO2NHR' wherein R' represents linear or branched (C1-C6)alkyl, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same, which are useful as AMPA inhibitors.

公开(公告)号：FR2818641B1

公开(公告)日：2004-03-05

申请号：FR0016739

申请日：2000-12-21

Applicant: SERVIER LAB

Inventor： MADELMONT JEAN CLAUDE ,  GIRAUD ISABELLE ,  VIDAL AURELIEN ,  MOUNETOU EMMANUELLE ,  RAPP MARYSE ,  MAURIZIS JEAN CLAUDE ,  RENARD PIERRE ,  CAIGNARD DANIEL HENRI ,  BIZOT ESPIARD JEAN GUY

IPC: A61K31/5415 ,  A61P19/02 ,  A61P19/08 ,  A61P29/00 ,  A61P43/00 ,  C07D279/02 ,  C07D417/12

Abstract: wherein: represents a single or double bond, R1 represents a hydrogen atom or a hydroxy, alkoxy, acyloxy, alkylsulphonyloxy, arylsulphonyloxy or arylalkoxy group, R2 represents a hydrogen atom or an alkyl group, R3 and R4, which may be identical or different, each represent a hydrogen atom, a halogen atom or an alkyl, hydroxy or alkoxy group, Ak represents an alkylene chain, R5, R6 and R7, which may be identical or different, each represent an alkyl group, or R5, R6 and R7, taken together with the nitrogen atom carrying them, form a saturated or unsaturated nitrogen-containing heterocycle, X represents a halogen atom, and its optical isomers when they exist. Medicaments.

公开(公告)号：FR2819253A1

公开(公告)日：2002-07-12

申请号：FR0100313

申请日：2001-01-11

Applicant: SERVIER LAB

Inventor： HANESSIAN STEPHEN ,  MOITESSIER NICOLAS ,  GAUCHET CECILE ,  HICKMAN JOHN ,  TUCKER GORDON ,  CAIGNARD DANIEL HENRI ,  RENARD PIERRE

IPC: A61P19/00 ,  A61P25/00 ,  A61P35/00 ,  C07C323/60 ,  C07D213/40 ,  C07D213/06 ,  A61K31/145 ,  A61K31/44 ,  A61K31/5375 ,  C07C311/15 ,  C07D265/28

Abstract: Hydroxamic acid derivatives (I), their optical isomers and salts with acids and bases are new. Hydroxamic acid derivatives of formula (I), their optical isomers and salts with acids and bases are new. n = 0 - 2; R1 = R1a when n is zero, and is R1b when n is 1 or 2; R1a = -Ak-CO-NR'1aR''1a; R'1a = H; Ak = 1-6C alkylene; R''1a = 3-8C cycloalkyl or 1-6C alkyl (substituted by one or more heteroaryl groups); or NR'1aR''1a = form a nitrogen heterocycle; R1b = -Ak-CO-NR'1bR''1b; R'1b and R''1b = H, 3-8C cycloalkyl, 1-6C alkyl (optionally substituted by aryl, heteroaryl or cycloalkyl groups); R2 = aryl 1-6C alkyl or heteroaryl 1-6C alkyl; Ar = aryl or heteroaryl. An Independent claim is included for the preparation of (I).

公开(公告)号：AU4117199A

公开(公告)日：2000-02-17

申请号：AU4117199

申请日：1999-07-27

Applicant: SERVIER LAB

Inventor： RAULT SYLVAIN ,  RENARD PIERRE ,  CAIGNARD DANIEL HENRI ,  PIERRE ALAIN ,  ATASSI GHANEM ,  ROBBA MAX ,  LANCELOT JEAN-CHARLES ,  ENGUEHARD CECILE

IPC: A61K31/00 ,  A61K31/40 ,  A61K31/407 ,  A61P35/00 ,  C07D495/14 ,  C07D513/04

Abstract: A compound selected from those of formula (I): wherein: R1 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino, R2 represents optionally substituted aryl or heteroaryl, R3 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino, their isomers and addition pharmaceutically-acceptable acid or base salts thereof and medicinal products containing the same are useful in the treatment of cancer.