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公开(公告)号：ES2718603T3
公开(公告)日：2019-07-03
申请号：ES14854037
申请日：2014-10-17
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , FEHER MIKLOS , PAULS HEINZ W
IPC: C07D413/14 , A61K31/5377 , A61P35/00
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公开(公告)号：CA2850394C
公开(公告)日：2019-05-21
申请号：CA2850394
申请日：2012-10-12
Applicant: UNIV HEALTH NETWORK
Inventor： PAULS HEINZ W , LAUFER RADOSLAW , LIU YONG , LI SZE-WAN , FORREST BRYAN T , LANG YUNHUI , PATEL NARENDRA KUMAR B , EDWARDS LOUISE G , SAMPSON PETER BRENT , FEHER MIKLOS , AWREY DONALD E , NG GRACE
IPC: C07D401/00 , A61K31/416 , A61P35/00 , C07D231/56 , C07D401/02 , C07D401/14 , C07D403/02 , C07D405/14 , C07D409/14 , C07D451/06 , C07D491/107
Abstract: The present teaching provide indazole compounds represented by Structural Formulae (I) or (I') or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.
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公开(公告)号：HRP20190564T1
公开(公告)日：2019-05-17
申请号：HRP20190564
申请日：2019-03-22
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , FEHER MIKLOS , PAULS HEINZ W
IPC: C07D413/14 , A61K31/5377 , A61P35/00
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公开(公告)号：RS58413B1
公开(公告)日：2019-04-30
申请号：RSP20190269
申请日：2014-10-17
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , FEHER MIKLOS , PAULS HEINZ W
IPC: C07D413/14 , A61K31/5377 , A61P35/00
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公开(公告)号：AU2017299850A8
公开(公告)日：2019-03-21
申请号：AU2017299850
申请日：2017-07-13
Applicant: UNIV HEALTH NETWORK
Inventor： LI SZE-WAN , PAULS HEINZ W , SAMPSON PETER BRENT
IPC: C07D487/04 , A61K31/519 , A61P35/00 , C30B7/02
Abstract: The present invention relates to a novel co-crystal of the compound of formula (I): (Formula (I)) wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal.
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Patent Agency Ranking
公开(公告)号：LT3057965T
公开(公告)日：2019-03-12
申请号：LT14854037
申请日：2014-10-17
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , FEHER MIKLOS , PAULS HEINZ W
IPC: C07D413/14 , A61K31/5377 , A61P35/00
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公开(公告)号：EA031569B1
公开(公告)日：2019-01-31
申请号：EA201690755
申请日：2014-10-17
Applicant: UNIV HEALTH NETWORK
Inventor： SAMPSON PETER BRENT , FEHER MIKLOS , PAULS HEINZ W
IPC: C07D413/14 , A61K31/5377 , A61P35/00
Abstract: Раскрытыфумаратнаясольи малеатнаясольсоединения (I), представленногоприведеннойнижеструктурнойформулой, атакжесоответствующиефармацевтическиекомпозициинаихоснове. Конкретныемонокристаллическиеформы 1:1 фумаратасоединения (I) и 1:1 малеатасоединения (I) характеризуютсярядомсвойстви физическихпараметров. Такжераскрытыспособыполучениямонокристаллическихформ 1:1 фумаратасоединения (I) и 1:1 малеатасоединения (I). Настоящееизобретениетакжеотноситсяк способамлечениясубъектасозлокачественнойопухолью.
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公开(公告)号：AU2017299850A1
公开(公告)日：2019-01-24
申请号：AU2017299850
申请日：2017-07-13
Applicant: UNIV HEALTH NETWORK
Inventor： LI SZE-WAN , PAULS HEINZ W , SAMPSON PETER BRENT
IPC: C07D487/04 , A61K31/519 , A61P35/00 , C30B7/02
Abstract: The present invention relates to a novel co-crystal of the compound of formula (I): (Formula (I)) wherein the co-former molecule is bisphosphate hemihydrate, to processes for the preparation of the co-crystal, to pharmaceutical compositions containing the co-crystal, to the use of such a co-crystal in the manufacture of a medicament for use in the treatment of cancer and to methods of treating such diseases in the human or animal body by administering a therapeutically effective amount of such a co-crystal.
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公开(公告)号：RS57481B1
公开(公告)日：2018-10-31
申请号：RSP20180775
申请日：2014-11-14
Applicant: UNIV HEALTH NETWORK
Inventor： LAUFER RADOSLAW , NG GRACE , LI SZE-WAN , PAULS HEINZ W , LIU YONG , PATEL NARENDRA KUMAR B
IPC: C07D487/04 , A61K31/519 , A61P35/00
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公开(公告)号：PL3068786T3
公开(公告)日：2018-10-31
申请号：PL14861448
申请日：2014-11-14
Applicant: UNIV HEALTH NETWORK
Inventor： LAUFER RADOSLAW , NG GRACE , LI SZE-WAN , PAULS HEINZ W , LIU YONG , PATEL NARENDRA KUMAR B
IPC: C07D487/04 , A61K31/519 , A61P35/00
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