公开(公告)号：US20050036914A1

公开(公告)日：2005-02-17

申请号：US10785411

申请日：2004-02-25

Applicant: Kazunori Yamauchi

Inventor： Kazunori Yamauchi

IPC: G01N21/47 ,  G01N21/78 ,  G01N21/86 ,  G01N21/00

CPC classification number: G01N30/90 ,  G01N21/474 ,  G01N21/78 ,  G01N21/8483 ,  G01N2201/064 ,  G01N2201/0813

Abstract: A measuring device for immunochromatography test piece comprising an irradiation optical system for irradiating measurement light onto an immunochromatography test piece, and a detection optical system for detecting reflected light from the immunochromatography test piece under irradiation with the measurement light. The irradiation optical system comprises a semiconductor light emitting element, a beam shaping member, a lens, a first baffle portion, a second baffle portion, and a third baffle portion. The beam shaping member shapes light from the semiconductor light emitting element, into a beam of a beam section extending in a direction substantially parallel to a colored line formed on the immunochromatography test piece. The lens focuses the beam from the beam shaping member on the immunochromatography test piece. The first baffle portion removes stray light, which is disposed between the semiconductor light emitting element and the beam shaping member. The second baffle portion removes stray light, which is disposed between the beam shaping member and the lens. The third baffle portion removes stray light, which is disposed between the lens and the immunochromatography test piece.

Abstract translation: 一种用于免疫层析试片的测量装置，包括用于将测量光照射到免疫层析试片上的照射光学系统，以及用于在用测量光照射下检测来自免疫层析试片的反射光的检测光学系统。 照射光学系统包括半导体发光元件，光束整形元件，透镜，第一挡板部分，第二挡板部分和第三挡板部分。 光束成形构件将来自半导体发光元件的光成形为沿与免疫层析试片上形成的彩色线基本平行的方向延伸的光束部分的光束。 透镜将来自光束成形构件的光束聚焦在免疫层析试片上。 第一挡板部分去除杂散光，其设置在半导体发光元件和光束成形构件之间。 第二挡板部分去除杂散光，其设置在光束成形构件和透镜之间。 第三挡板部分去除杂散光，其设置在透镜和免疫层析试片之间。

公开(公告)号：US20010007497A1

公开(公告)日：2001-07-12

申请号：US09748170

申请日：2000-12-27

Applicant: SHIMADZU CORPORATION

Inventor： Yoichi Fujiyama

IPC: G01N021/05

CPC classification number: G01N21/05 ,  G01N2021/0346 ,  G01N2201/064

Abstract: A measuring cell is formed of base plates joined together. A passage groove is formed on a joining surface of one base plate. Through-holes for introducing and discharging a fluid sample are formed on the other base plate, and the joining surface is provided with an optically opaque Si film as slits. Further, the joining surfaces of the base plates and the inner surface of the passage groove are covered with SiO2 films. Thus, a measuring cell having a sufficiently small passage sectional area, a high air-tightness, a chemically stable measuring chamber, and a high measuring sensitivity can be obtained.

Abstract translation: 测量单元由连接在一起的基板形成。 在一个基板的接合面上形成通道槽。 在另一个基板上形成用于引入和排出流体样品的通孔，并且接合表面设置有不透光的Si膜作为狭缝。 此外，基板的接合面和通道槽的内表面被SiO 2膜覆盖。 因此，可以获得具有足够小的通道截面积，高气密性，化学稳定的测量室和高测量灵敏度的测量池。

公开(公告)号：US5838429A

公开(公告)日：1998-11-17

申请号：US855918

申请日：1997-05-14

Applicant: Andreas Hahn

Inventor： Andreas Hahn

IPC: G01N21/25 ,  G01N21/31 ,  G01N33/48 ,  G01J1/04

CPC classification number: G01N21/255 ,  G01N21/3151 ,  G01N2021/3144 ,  G01N2201/0224 ,  G01N2201/0612 ,  G01N2201/064 ,  G01N2201/065

Abstract: The invention relates to an apparatus for measuring physiological parameters of blood conveyed within an extracorporeal circulatory system. Two light sources (1a, 1b) emit light of varying wavelength into a spherical cavity (3) that comprises a reflective inner surface (3a). Light sensor means (2) receives part of the light propagating within the cavity (3). A tube portion of the extracorporeal circulation can be inserted into a second cavity (4) such that the light (La, Lb) emitted by the light sources encounters the boundary surface between the blood and an inner wall of the tube. The light returns to the cavity (3) at least to an extent by means of reflection and/or transmission.

Abstract translation: 本发明涉及一种用于测量在体外循环系统内输送的血液的生理参数的装置。 两个光源（1a，1b）将变化波长的光发射到包括反射内表面（3a）的球形腔（3）中。 光传感器装置（2）接收在空腔（3）内传播的一部分光。 体外循环的管部分可以插入第二腔（4）中，使得由光源发射的光（La，Lb）遇到血液和管的内壁之间的边界面。 光通过反射和/或透射至少在一定程度上返回到空腔（3）。

公开(公告)号：US5159412A

公开(公告)日：1992-10-27

申请号：US670040

申请日：1991-03-15

Applicant: David L. Willenborg ,  Allan Rosencwaig ,  Jon Opsal

Inventor： David L. Willenborg ,  Allan Rosencwaig ,  Jon Opsal

IPC: G01B11/06 ,  G01M11/00 ,  G01N21/21 ,  G01N21/55 ,  G01N21/84

CPC classification number: G01N21/55 ,  G01B11/0616 ,  G01N21/211 ,  G01N21/8422 ,  G01N2201/064

Abstract: An approach for increasing the sensitivity of a high resolution measurement device 50 is disclosed. The device includes a laser 52 for generating a probe beam 54 which is tightly focused onto the surface of the sample 58. A detector 66 is provided for monitoring a parameter of the reflected probe beam. In accordance with the subject invention, a spatial filter is provided for reducing the amount of light energy reaching the detector that has been reflected from areas on the surface of the sample beyond the focused spot. The spatial filter includes a relay lens 68 and a blocking member 70 located in the focal plane of the lens. The blocking member 70 includes an aperture 72 dimensioned to block light reflected from the surface of the sample beyond a predetermined distance from the center of the focused spot. In this manner, greater sensitivity to sample characteristics within the highly focused spot is achieved.

公开(公告)号：US5108179A

公开(公告)日：1992-04-28

申请号：US391481

申请日：1989-08-09

Applicant: Stephen A. Myers

Inventor： Stephen A. Myers

IPC: G01N21/64 ,  G01N27/447

CPC classification number: G01N21/6428 ,  G01N21/645 ,  G01N27/44721 ,  G01N2021/6439 ,  G01N2021/6463 ,  G01N21/6402 ,  G01N21/6456 ,  G01N2201/064 ,  G01N2201/1042

Abstract: The use of continuous wave (CW) laser excitation to measure small differences in the fluorescence of bands of fluorophore stained nucleic acid fragments present in gels is described.

Abstract translation: 描述了使用连续波（CW）激光激发来测量存在于凝胶中的荧光团染色的核酸片段的荧光的微小差异。

公开(公告)号：US4632559A

公开(公告)日：1986-12-30

申请号：US704767

申请日：1985-02-21

Applicant: Albert Brunsting

Inventor： Albert Brunsting

IPC: G01N21/47 ,  G01J3/51

CPC classification number: G01N21/474 ,  G01N2021/478 ,  G01N2201/064

Abstract: Reflectance apparatus is disclosed for obtaining measurement of nonspecular reflected light in which controlled light rays are directed by means of a lens and transmission path from a light source through a light trap to expose or illuminate a specimen and nonspecular reflected light is passed from the specimen through the light trap along a transmission path to one or more detectors where the nonspecular reflected light is measured.

Abstract translation: 公开了用于获得非限制性反射光的测量的反射装置，其中受控光线通过透镜和来自光源的通过光阱的透射路径被引导以暴露或照亮样本，并且非特异性反射光从样本通过 沿着传输路径到一个或多个检测器的光阱，其中测量非特异性反射光。

公开(公告)号：US3734601A

公开(公告)日：1973-05-22

申请号：US3734601D

申请日：1971-07-08

Applicant: BAXTER LABORATORIES INC

Inventor： HEISS L

IPC: G01N21/05 ,  G01N21/64 ,  G01N21/85 ,  G01N1/10 ,  G01N21/00

CPC classification number: G01N21/645 ,  G01N21/05 ,  G01N21/251 ,  G01N21/85 ,  G01N2021/054 ,  G01N2201/064

Abstract: A flow cell assembly for adapting an apparatus for both fluorometric and colorimetric studies. The assembly includes a holder having a folded optical path between an external light source and photosensitive response means. The light input to the optical path is at right angles to the light output therefrom so that the assembly may be employed in place of the sample cuvette of a conventional spectrofluorescence measuring instrument. The holder contains a flow tube having an offset sight passageway portion supported endwise in the optical path. The holder includes a light shield plate slotted to receive the legs of the offset portion and to substantially protect the offset sight passageway portion and the folded optical path from stray light. The flow tube may include an integral debubbler.

Abstract translation: 用于适应荧光和比色研究的装置的流动池组件。 组件包括在外部光源和光敏应答装置之间具有折叠光路的保持器。 输入到光路的光线与从其输出的光线成直角，因此可以使用该组件来代替传统的分光荧光测量仪器的样品杯。 保持器包括流管，其具有在光路中端向支撑的偏移视线通道部分。 保持器包括开槽的光屏蔽板，以接收偏移部分的腿部并且基本上保护偏移视线通道部分和折叠的光路免受杂散光线的影响。 流动管可以包括整体脱泡器。

公开(公告)号：US11703460B2

公开(公告)日：2023-07-18

申请号：US16913396

申请日：2020-06-26

Applicant: KLA Corporation

Inventor： Zhiwei Xu ,  Kurt Haller ,  J. K. Leong ,  Christian Wolters

IPC: G01N21/95 ,  G01N21/45

CPC classification number: G01N21/9505 ,  G01N21/45 ,  G01N2201/064 ,  G01N2201/06113

Abstract: Methods and systems for detecting and classifying defects based on the phase of dark field scattering from a sample are described herein. In some embodiments, throughput is increased by detecting and classifying defects with the same optical system. In one aspect, a defect is classified based on the measured relative phase of scattered light collected from at least two spatially distinct locations in the collection pupil. The phase difference, if any, between the light transmitted through any two spatially distinct locations at the pupil plane is determined from the positions of the interference fringes in the imaging plane. The measured phase difference is indicative of the material composition of the measured sample. In another aspect, an inspection system includes a programmable pupil aperture device configured to sample the pupil at different, programmable locations in the collection pupil.

公开(公告)号：US20180136133A1

公开(公告)日：2018-05-17

申请号：US15461613

申请日：2017-03-17

Applicant: BWT PROPERTY, INC.

Inventor： Jun Zhao ,  Xin Jack Zhou ,  Sean Xiaolu Wang

IPC: G01N21/65 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01J3/0216 ,  G01J3/0218 ,  G01J3/4406 ,  G01N21/474 ,  G01N21/645 ,  G01N2201/064 ,  G01N2201/08

Abstract: This invention relates to a light delivery and collection device for performing spectroscopic analysis of a subject. The light delivery and collection device comprises a reflective cavity with two apertures. The first aperture is configured to receive excitation light which then diverges and projects onto the second aperture. The second aperture is configured to be applied close to the subject such that the reflective cavity substantially forms an enclosure covering a large area of the subject. The excitation light enters and interacts with the covered area of the subject to produce inelastic scattering and/or fluorescence emission from the subject. The reflective cavity has a specular reflective surface with high reflectivity to the excitation light as well as to the inelastic scattering and/or fluorescence emission from the subject. The reflective cavity reflects the excitation light that is reflected and/or back-scattered from the subject and redirects it towards the subject. This causes more excitation light to penetrate into a diffusely scattering subject to produce inelastic scattering and/or fluorescence emission from inside of the subject hence enabling sub-surface measurement. In addition, the reflective cavity reflects the inelastic scattering and/or fluorescence emission from the subject unless the inelastic scattering and/or fluorescence emission either emits from the first aperture of the reflective cavity to be measured with a spectrometer device, or re-enters the subject at the second aperture. This multi-reflection process improves the collection efficiency of the inelastic scattering or fluorescence emission from the subject.

公开(公告)号：US20180059031A1

公开(公告)日：2018-03-01

申请号：US15557904

申请日：2016-03-03

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： THOMAS J. BRACE ,  PHILLIP A. BOLEA ,  GIUSEPPE M. BOMMARITO ,  MICHELE A. WALDNER ,  STEPHEN R. ALEXANDER ,  FUSU THAO ,  KATLEEN M. STENERSEN

IPC: G01N21/94 ,  C12Q1/00 ,  C12Q1/66 ,  G01N21/76 ,  C12Q1/22

CPC classification number: G01N21/94 ,  C12Q1/008 ,  C12Q1/22 ,  C12Q1/66 ,  C12Q2304/60 ,  G01J1/0223 ,  G01J1/0233 ,  G01J1/0271 ,  G01J1/42 ,  G01N21/763 ,  G01N2201/021 ,  G01N2201/022 ,  G01N2201/0221 ,  G01N2201/064 ,  G01N2201/0646

Abstract: Various embodiments of a light detection device and a method of using the device are disclosed. In one or more embodiments, the light detection device can include a housing that extends along a housing axis between top and bottom surfaces. The device can also include a port that is adapted to receive a sample, and a door connected to the housing. The door can include an actuator portion adapted to selectively move the door between a closed position and an open position, and a cover portion connected to the actuator portion and adapted to close the port when the door is in the closed position and open the port when the door is in the open position to allow external access to the port.