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    INTEGRATED BOUND-MODE SPECTRAL/ANGULAR SENSORS
    103.
    发明公开
    INTEGRATED BOUND-MODE SPECTRAL/ANGULAR SENSORS 审中-公开
    INTEGRIERTE SPEKTREN- / WINKELSENSOREN IM VERBUNDENEN MODUS

    公开(公告)号：EP3152788A1

    公开(公告)日：2017-04-12

    申请号：EP15807428.6

    申请日：2015-06-09

    Applicant: Stc.Unm

    Inventor： BRUECK, Steven, R., J. ,  NEUMANN, Alexander ,  ZARKESH-HA, Payman

    IPC: H01L33/58 ,  H01L33/48 ,  F21S2/00

    CPC classification number: G01J1/06 ,  G01J1/44 ,  G01J3/0218 ,  G01J3/0259 ,  G01J3/18 ,  G01J3/1895 ,  G01J3/2803 ,  G01J2001/448 ,  G02B6/00 ,  G02B6/10 ,  G02B6/12004 ,  G02B6/122 ,  G02B6/124 ,  H01L27/1446 ,  H01L31/02019 ,  H01L31/02164 ,  H01L31/02327 ,  H01L31/103

    Abstract: A 2-D sensor array includes a semiconductor substrate and a plurality of pixels disposed on the semiconductor substrate. Each pixel includes a coupling region and a junction region, and a slab waveguide structure disposed on the semiconductor substrate and extending from the coupling region to the region. The slab waveguide includes a confinement layer disposed between a first cladding layer and a second cladding layer. The first cladding and the second cladding each have a refractive index that is lower than a refractive index of the confinement layer. Each pixel also includes a coupling structure disposed in the coupling region and within the slab waveguide. The coupling structure includes two materials having different indices of refraction arranged as a grating defined by a grating period. The junction region comprises a p-n junction in communication with electrical contacts for biasing and collection of carriers resulting from absorption of incident radiation.

    Abstract translation: 2维传感器阵列包括半导体衬底和设置在半导体衬底上的多个像素。 每个像素包括耦合区域和结区域，以及设置在半导体衬底上并从耦合区域延伸到该区域的平板波导结构。 平板波导包括设置在第一包层和第二包层之间的限制层。 第一包层和第二包层各自具有低于限制层的折射率的折射率。 每个像素还包括设置在耦合区域中并且在平板波导内的耦合结构。 耦合结构包括具有不同的折射率布置为由光栅周期限定的光栅的两种材料。 结区域包括与电触点连通的p-n结，用于偏移和收集由吸收入射辐射引起的载流子。

    POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY AND METHODS OF USING SAME
    107.
    发明公开
    POROUS NANOPARTICLE-SUPPORTED LIPID BILAYERS (PROTOCELLS) FOR TARGETED DELIVERY AND METHODS OF USING SAME 审中-公开
    用于目标递送的多孔纳米颗粒支持的脂质双层膜（方案）及使用相同方法

    公开(公告)号：EP2701686A2

    公开(公告)日：2014-03-05

    申请号：EP12776480.1

    申请日：2012-04-27

    Applicant: STC.UNM ,  Sandia Corporation

    Inventor： BRINKER, Jeffrey, C. ,  CARNES, Eric, C. ,  ASHLEY, Carlee, Erin

    IPC: A61K9/16 ,  A61K47/48 ,  A61K47/30 ,  A61K38/17 ,  A61K48/00

    CPC classification number: A61K9/1271 ,  A61K31/704 ,  A61K31/711 ,  A61K33/24 ,  A61K38/00 ,  A61K39/05 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6901 ,  A61K48/0016 ,  C07K14/47 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40

    Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

    Abstract translation: 本发明涉及用于特异性靶向肝细胞和其他癌细胞的原始细胞，其包含具有支持的脂质双层的纳米多孔二氧化硅核心; 至少一种促进癌细胞死亡的试剂（例如传统小分子，大分子货物（例如siRNA或诸如蓖麻毒素A链或白喉毒素A链的蛋白毒素）和/或组蛋白包装的质粒DNA 设置在纳米多孔二氧化硅核心内（优选超螺旋以便更有效地将DNA包装到原始细胞中），其任选地用核定位序列修饰以帮助定位癌细胞核内的原始细胞和表达参与治疗的肽的能力 （细胞凋亡/细胞死亡）或作为报道分子，靶向肽靶向待治疗的组织中的癌细胞，使得原始细胞与靶细胞的结合是特异性的并且增强，促进融合肽促进内体的逃逸 原始细胞和胶囊化的DNA，根据本发明的原始细胞可以用于治疗癌症，特别是包括肝细胞（肝脏）癌症 新型结合肽（c-MET肽），其选择性结合肝细胞组织或用于诊断癌症，包括癌症治疗和药物发现。

    STEP-DERIVED PEPTIDE FOR BRAIN INJURY TREATMENT
    108.
    发明公开
    STEP-DERIVED PEPTIDE FOR BRAIN INJURY TREATMENT 审中-公开
    逐步发展肽脑损伤的治疗

    公开(公告)号：EP2616485A2

    公开(公告)日：2013-07-24

    申请号：EP11825972.0

    申请日：2011-09-15

    Applicant: STC.UNM

    Inventor： PAUL, Surojit

    IPC: C07K14/47 ,  C07K19/00 ,  A61K38/17 ,  A61P25/00

    CPC classification number: C12N9/16 ,  A61K38/00 ,  A61K38/465 ,  C12Y301/03048

    Abstract: A novel peptide sequence that is a modified derivative of a neuron-specific tyrosine phosphatase is shown and described. Specifically, the novel peptide sequence is a modified derivative of striatal-enriched tyrosine phosphatase (STEP). The peptide sequence has been modified so as to be able to ameliorate and treat brain injury resulting from excessive glutamate release and / or oxidative stress. Examples of the types of brain injury which the presently disclosed peptide sequence is useful for treating includes acute brain injury resulting from stroke or traumatic brain injury and chronic disorders such as Huntington's chorea and schizophrenia. Furthermore, the presently described peptide sequence may further be useful in the treatment and amelioration of disorders associated with fear memory such as post-traumatic stress disorder.

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