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    METHOD FOR PRODUCING ESTERS FREE OF ENANTIOMERS
    101.
    发明专利
    METHOD FOR PRODUCING ESTERS FREE OF ENANTIOMERS 未知

    公开(公告)号：CA2274247A1

    公开(公告)日：1998-08-27

    申请号：CA2274247

    申请日：1998-02-09

    Applicant: BASF AG

    Inventor： HOLMAN NICHOLAS JOHN ,  BALKENHOHL FRIEDHELM ,  KOSER STEFAN

    IPC: C07D487/04 ,  C12P17/18 ,  C12P41/00

    Abstract: The invention relates to a method for producing enantiomer-free esters of formula (I) (Ia or Ib), where the substituents represent the following: R1 is a hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl; R2 and R3 independently of each other are hydrogen or a substituted or unsubstituted C1-C6-alkyl-, C1-C6-alkoxy-, or C1-C6-alkanoyl-, C1-C6-alkylthio-, C1-C6-alkyl sulfinyl or C1-C6-alkyl sulfonyl-; R4 is not equal to R5 and independently of each other they are either hydrogen or an substituted or unsubstituted C1-C6-alkyl-, or together with the hydrogen atoms, to which they are bound, form a substituted or unsubstituted C3-C6-cyclo alkylidene; and R6 is a substituted or unsubstituted aryl-, C1-C20-alkyl-, C3-C20-alkenyl-, C3-C20-alkynyl-, C1-C20-alkoxy-C1-C20-alkyl. The method is characterized in that racemic compounds of the formula (II), in which the substituents R1 to R5 have the meanings given above, are reacted with a lipase or esterase in the presence of vinyl esters of formula (III), where R6 has the meaning given above and R7 represents hydrogen or methyl, to form compounds of formula (I).

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