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公开(公告)号：BRPI0507308A
公开(公告)日：2007-06-26
申请号：BRPI0507308
申请日：2005-01-21
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： WERLING JANE , CHAUBAL MAHESH V , KIPP JAMES E , RABINOW BARRETT E
IPC: A61K9/10 , A61K9/14 , A61K9/51 , A61K31/00 , A61K31/551 , A61K31/7072 , A61K31/7076
Abstract: The present invention provides compositions comprising dispersions of anti-retroviral agents and methods of manufacture. The nanosuspensions are made by the process of microprecipitation and energy addition. Preferably, the nanosuspensions are made by the tandem process of microprecipitation-homogenization.
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公开(公告)号：ZA200506900B
公开(公告)日：2006-08-30
申请号：ZA200506900
申请日：2005-08-29
Applicant: BAXTER INT
Inventor： KIPP JAMES E , WONG JOSEPH C T , WELING JANE R C L , BRYNJELSEN SEAN
IPC: A61K20060101 , A61K9/10 , A61K9/14 , A61K9/16 , A61K31/12 , A61K31/337 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/573
Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 mum. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.
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公开(公告)号：CA2591554A1
公开(公告)日：2006-08-03
申请号：CA2591554
申请日：2005-12-15
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： HAI TON THAT , KIPP JAMES E , MELNICK BENNETT P
IPC: C08G65/326 , C08G65/334 , C08L71/02
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公开(公告)号：AU2005326168A1
公开(公告)日：2006-08-03
申请号：AU2005326168
申请日：2005-12-15
Applicant: BAXTER HEALTHCARE SA , BAXTER INT
Inventor： HAI TON THAT , MELNICK BENNETT P , KIPP JAMES E
IPC: C08G65/326 , C08G65/334 , C08L71/02
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公开(公告)号：AU2005304952A1
公开(公告)日：2006-05-18
申请号：AU2005304952
申请日：2005-11-03
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： KIPP JAMES E , ROESSLER BERTHOLD , DOTY MARK , PAPADOPOULOS PAVLOS
IPC: A61K31/404 , A61K9/00 , A61P35/00
Abstract: The present invention is directed to novel pharmaceutical compositions comprising nano- and micro-particulate formulations of poorly water soluble tubulin inhibitors of the indole chemical class, preferably N-substituted indol-3-glyoxyamides, and more preferably N-(Pyridin-4-yl)-[1-(4-chlorobenzyl)-indol-3-yl]glyoxylic acid amide (D-24851), also known as “Indibulin,” and methods of making and using such compositions for the treatment of anti-tumor agent resistant cancers and other diseases.
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Patent Agency Ranking
公开(公告)号：AT317695T
公开(公告)日：2006-03-15
申请号：AT01923027
申请日：2001-03-30
Applicant: BAXTER INT
Inventor： KIPP JAMES E , DOTY MARK J , REBBECK CHRISTINE L , EILERT JAN Y
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公开(公告)号：BRPI0408707A
公开(公告)日：2006-03-07
申请号：BRPI0408707
申请日：2004-03-24
Applicant: BAXTER INT
Inventor： KIPP JAMES E , WONG JOSEPH CHUNG TAK , WISLER MONTE , GARCIA RHONDA
Abstract: Methods and apparatuses for comminuting and stabilizing small particles are provided. In one embodiment, an apparatus moves an organic compound dissolved in a solvent to form a suspension of particles in a first fluid stream and moves the suspension in a second fluid stream, wherein the second fluid stream is oriented and positioned with respect to the first stream to cause shearing between the streams and mixing of at least some of the particles in the first and second streams.
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公开(公告)号：NO20054732A
公开(公告)日：2005-10-14
申请号：NO20054732
申请日：2005-10-14
Applicant: BAXTER INT
Inventor： KIPP JAMES E , WONG JOSEPH CHUNG TAK , REBBECK CHRISTINE L , BRYNJELSEN SEAN , WERLING JANE
IPC: A61K9/10 , A61K9/14 , A61K9/16 , A61K31/12 , A61K31/337 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/573
CPC classification number: A61K31/495 , A61K9/10 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1682 , A61K9/1688 , A61K31/12 , A61K31/337 , A61K31/496 , A61K31/55 , A61K31/573
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公开(公告)号：NO20052285L
公开(公告)日：2005-05-10
申请号：NO20052285
申请日：2005-05-10
Applicant: BAXTER INT
Inventor： KIPP JAMES E , WONG JOSEPH CHUNG TAK , DOTY MARK J , REBBECK CHRISTINE L , PAPADOPOULOS PAVLOS
IPC: A61K9/10 , A61K9/14 , A61K9/16 , A61K9/50 , A61K31/495 , A61K31/496
Abstract: The present invention relates to compositions of submicron-to micron-size particles of antifungal agents. More particularly the invention relates to aqueous suspensions of antifungal agents for pharmaceutical use.
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公开(公告)号：AU2004249172A1
公开(公告)日：2004-12-29
申请号：AU2004249172
申请日：2004-06-15
Applicant: BAXTER INT
Inventor： KIPP JAMES E , GENDELMAN HOWARD E , RABINOW BARRETT E
Abstract: The present invention is concerned with delivering a pharmaceutical composition to the brain of a mammalian subject for treating brain diseases or disorders. The process includes the steps of: (i) providing a dispersion of the pharmaceutical composition as particles having an average particle size of from about 150 nm to about 100 microns, and (ii) administering the dispersion to the mammalian subject for delivery to the brain of a portion of the pharmaceutical composition by cells capable of reaching the brain. The dispersion of the pharmaceutical composition as particles, for example, can be phagocytized or adsorbed by the cells prior or subsequent to administration into the mammalian subject. The dispersion of the pharmaceutical composition can be administered to the central nervous system or the vascular system. After administration, the loaded cells transport the pharmaceutical composition as particles into the brain.
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