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公开(公告)号：EP0606450A4
公开(公告)日：1996-06-05
申请号：EP93917203
申请日：1993-07-14
Applicant: BAXTER INT
Inventor： BANCSI JOSEPH A , ELLER CHARLES , FOWLES THOMAS A , GORMAN BRIAN J , HEBRON TERRENCE J , JERSILD CHARLES , JESS DONALD A , WONG JOSEPH C T , WOOD RAY W
CPC classification number: A61M5/1409 , Y10S604/905
Abstract: The present invention provides an improved cannula (22) that can be used to reconstitute powdered drugs in a drug delivery system. Furthermore, the present invention provides a cannula (22) and drug delivery system incorporating same. To this end, the present invention provides a cannula structure for use in a reconstitution of a powdered drug comprising a cannula (22) having a first end (26) and a second end (28), and defining a channel in an interior thereof between the first and second ends (26, 28). The first end (26) is closed and includes a member (27) for piercing a septum (42). The cannula (22) includes at least two slots (50a, 50b) providing fluid communication between the channel and an exterior of the cannula (22). The slots (50a, 50b) are located in juxtaposition to the first end (26) and have a width, as measured along a length of the cannula (22), that is less than a length, as measured around the cannula (22). The slots (50a, 50b) also have a minimum projected area equal to or greater than the cross-sectional area of the channel.
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公开(公告)号：CA2722602A1
公开(公告)日：2009-11-19
申请号：CA2722602
申请日：2009-05-08
Applicant: BAXTER INT , BAXTER HEALTHCARE SA
Inventor： KIPP JAMES E , WONG JOSEPH C T , NAIR LAKSHMY , MILLER REAGAN , RABINOW BARRETT E
Abstract: Stable pharmaceutical formulations and methods of making same are provided. In a general embodiment, the present disclosure provides a method of making a stable pharmaceutical formulation comprising adding one or more vitrifying additives to an aqueous pharmaceutical solution to raise the glass transition temperature of the aqueous pharmaceutical solution. The aqueous pharmaceutical solution can be cooled to a temperature of about -50 C to about -10 C. The vitrifying additive enhances the formation of a glass or amorphous solid of the aqueous pharmaceutical solution at cryogenic temperatures (-50 to -10C), and the pharmaceutical formulation can be thawed to liquid form and administered to a mammalian subject.
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公开(公告)号：CA2119124A1
公开(公告)日：1994-02-17
申请号：CA2119124
申请日：1993-07-14
Applicant: BAXTER INT
Inventor： BANCSI JOSEPH A , ELLER CHARLES , FOWLES THOMAS A , GORMAN BRIAN J , HEBRON TERRENCE J , JERSILD CHARLES , JESS DONALD A , WONG JOSEPH C T , WOOD RAY W
Abstract: The present invention provides an improved cannula that can be used to reconstitute powdered drugs in a drug delivery system. Furthermore, the present invention provides a cannula and drug delivery system incorporating same. To this end, the present invention provides a cannula structure for use in a reconstitution device for reconstituting a powdered drug comprising a cannula having a first end and a second end, and defining a channel in an interior thereof between the first and second ends. The first end is closed and includes a member for piercing a septum. The cannula includes at least two slots providing fluid communication between the channel and an exterior of the cannula. The slots are located in juxtaposition to the first end and have a width, as measured along a length of the cannula, that is less than a length, as measured around the cannula. The slots also have a minimum projected area equal to or greater than the cross-sectional area of the channel.
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Patent Agency Ranking
公开(公告)号：ZA200506900B
公开(公告)日：2006-08-30
申请号：ZA200506900
申请日：2005-08-29
Applicant: BAXTER INT
Inventor： KIPP JAMES E , WONG JOSEPH C T , WELING JANE R C L , BRYNJELSEN SEAN
IPC: A61K20060101 , A61K9/10 , A61K9/14 , A61K9/16 , A61K31/12 , A61K31/337 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/573
Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 mum. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.
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公开(公告)号：MX2010012451A
公开(公告)日：2010-12-07
申请号：MX2010012451
申请日：2009-05-08
Applicant: BAXTER INT
Inventor： KIPP JAMES E , RABINOW BARRETT E , WONG JOSEPH C T , NAIR LAKSHMY , MILLER REAGAN
Abstract: Se proporcionan formulaciones farmacéuticas estables y métodos para elaborarlas. En una modalidad general, la presente descripción proporciona un método para elaborar una formulación farmacéutica estable que comprende agregar uno o más aditivos de vitrificación a una solución farmacéutica acuosa para elevar la temperatura de transición al vidrio de la solución farmacéutica acuosa. La solución farmacéutica acuosa puede ser enfriada a una temperatura de aproximadamente -50°C hasta aproximadamente -10°C. El aditivo de vitrificación mejora la formación de un sólido de vidrio o amorfo de la solución farmacéutica acuosa en temperaturas criogénicas (-50°C a - 10°C), y la formulación farmacéutica puede ser descongelada a una forma líquida y administrada a un sujeto mamífero.
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公开(公告)号：AU4679493A
公开(公告)日：1994-03-03
申请号：AU4679493
申请日：1993-07-14
Applicant: BAXTER INT
Inventor： BANCSI JOSEPH A , ELLER CHARLES , FOWLES THOMAS A , GORMAN BRIAN J , HEBRON TERRENCE J , JERSILD CHARLES , JESS DONALD A , WONG JOSEPH C T , WOOD RAY W
Abstract: The present invention provides an improved cannula that can be used to reconstitute powdered drugs in a drug delivery system. Furthermore, the present invention provides a cannula and drug delivery system incorporating same. To this end, the present invention provides a cannula structure for use in a reconstitution device for reconstituting a powdered drug comprising a cannula having a first end and a second end, and defining a channel in an interior thereof between the first and second ends. The first end is closed and includes a member for piercing a septum. The cannula includes at least two slots providing fluid communication between the channel and an exterior of the cannula. The slots are located in juxtaposition to the first end and have a width, as measured along a length of the cannula, that is less than a length, as measured around the cannula. The slots also have a minimum projected area equal to or greater than the cross-sectional area of the channel.
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公开(公告)号：ZA200507308B
公开(公告)日：2006-07-26
申请号：ZA200507308
申请日：2005-09-12
Applicant: BAXTER INT
Inventor： KIPP JAMES E , WONG JOSEPH C T , WISLER MONTE , GARCIA RHONDA
IPC: A61K20060101
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公开(公告)号：AU664770B2
公开(公告)日：1995-11-30
申请号：AU4679493
申请日：1993-07-14
Applicant: BAXTER INT
Inventor： BANCSI JOSEPH A , ELLER CHARLES , FOWLES THOMAS A , GORMAN BRIAN J , HEBRON TERRENCE J , JERSILD CHARLES , JESS DONALD A , WONG JOSEPH C T , WOOD RAY W
Abstract: The present invention provides an improved cannula that can be used to reconstitute powdered drugs in a drug delivery system. Furthermore, the present invention provides a cannula and drug delivery system incorporating same. To this end, the present invention provides a cannula structure for use in a reconstitution device for reconstituting a powdered drug comprising a cannula having a first end and a second end, and defining a channel in an interior thereof between the first and second ends. The first end is closed and includes a member for piercing a septum. The cannula includes at least two slots providing fluid communication between the channel and an exterior of the cannula. The slots are located in juxtaposition to the first end and have a width, as measured along a length of the cannula, that is less than a length, as measured around the cannula. The slots also have a minimum projected area equal to or greater than the cross-sectional area of the channel.
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