公开(公告)号：AT366588T

公开(公告)日：2007-08-15

申请号：AT03000267

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/10 ,  A61K49/22 ,  A61K31/401 ,  A61K45/08 ,  A61K49/00

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：CA2200061C

公开(公告)日：2007-04-10

申请号：CA2200061

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： MATSUNAGA TERRY O ,  UNGER EVAN C ,  YELLOWHAIR DAVID

IPC: A61K9/127 ,  G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imagi ng and in therapeutic applications, is disclosed.

公开(公告)号：ES2159280T5

公开(公告)日：2005-03-16

申请号：ES92912456

申请日：1992-03-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61Q19/00 ,  B01J13/02

Abstract: SE PRESENTAN AGENTES DE CONTRASTE PARA TECNICAS DE FORMACION DE IMAGENES ULTRASONICAS QUE COMPRENDEN LIPOSOMAS RELLENOS DE GAS PREPARADOS UTILIZANDO METODOS DE DESTILACION DE GAS EN SECO, AL VACIO, Y LIPOSOMAS RELLANOS DE GAS SUBSTANCIALMENTE LIBRES DE LIQUIDO EN EL INTERIOR DE LOS MISMOS. SE PRESENTAN METODOS Y UN APARATO (119) PARA PREPARAR TALES LIPOSOMAS Y METODOS PARA EMPLEAR DICHOS LIPOSOMAS EN APLICACIONES DE FORMACION DE IMAGENES ULTRASONICAS. TAMBIEN SE DESCRIBEN EQUIPOS DE DIAGNOSTICO PARA LA FORMACION DE IMAGENES ULTRASONICAS QUE INCLUYEN LOS AGENTES DE CONTRASTE DESCRITOS.

公开(公告)号：DE69231950T3

公开(公告)日：2005-03-10

申请号：DE69231950

申请日：1992-03-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61Q19/00 ,  B01J13/02

Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.

公开(公告)号：DE69629478D1

公开(公告)日：2003-09-18

申请号：DE69629478

申请日：1996-06-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MCCREERY THOMAS ,  YELLOWHAIR DAVID ,  BARRETTE TERRENCE R

IPC: A61K49/00 ,  A61B5/055 ,  A61B8/00 ,  A61J3/00 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01F3/04 ,  B01F11/00 ,  B01F15/00

Abstract: A method and apparatus for making vesicles suitable for use as contrast agents in which a container containing an aqueous suspension phase and a separate gas phase is shaken using reciprocating motion. The reciprocating motion is produced by a shaker arm that moves the container in two, substantially perpendicular directions, with the motion in the first direction being along an arcuate path. The overall path of the motion occurs in a figure-8 eight pattern. The frequency of shaking is at least approximately 2800 RPM, the length of the shaker arm is at least approximately 6 cm, and the angle through which the shaker arm rotates in the first direction is at least approximately 3 DEG . The total length of travel around the figure-8 pattern is at least 0.7 cm.

公开(公告)号：AT243997T

公开(公告)日：2003-07-15

申请号：AT92912662

申请日：1992-03-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61K9/127 ,  A61K31/70 ,  A61K31/704 ,  A61K41/00 ,  A61K47/06 ,  A61K47/24 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  B01J13/02

公开(公告)号：PT977597E

公开(公告)日：2003-06-30

申请号：PT97940615

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K31/401 ,  A61K45/08 ,  A61K9/10 ,  A61K49/00 ,  A61K49/22 ,  A61B8/14

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：AT231004T

公开(公告)日：2003-02-15

申请号：AT97940615

申请日：1997-08-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/10 ,  A61K31/401 ,  A61K45/08 ,  A61K49/00 ,  A61K49/22 ,  A61B8/14

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

公开(公告)号：DE69231950T2

公开(公告)日：2002-01-17

申请号：DE69231950

申请日：1992-03-31

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61Q19/00 ,  B01J13/02

Abstract: Contrast agents for ultrasonic imaging comprising gas filled liposomes prepared using vacuum drying gas instillation methods, and gas filled liposomes substantially devoid of liquid in the interior thereof, are described. Methods of and apparatus for preparing such liposomes and methods for employing such liposomes in ultrasonic imaging applications are also disclosed. Also described are diagnostic kits for ultrasonic imaging which include the subject contrast agents.

公开(公告)号：DE69231830T2

公开(公告)日：2001-10-18

申请号：DE69231830

申请日：1992-03-18

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60 ,  C08F20/06 ,  A61K49/00 ,  A61K51/12 ,  C08F122/38 ,  C08F126/10 ,  C08J9/30 ,  G01R33/28