公开(公告)号：CA2256592C

公开(公告)日：2010-06-01

申请号：CA2256592

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61K49/00 ,  A61M5/00 ,  A61B8/00 ,  A61B8/13 ,  A61K9/127 ,  A61K49/22 ,  A61K51/02 ,  A61M5/14

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：EP0930844A4

公开(公告)日：2002-03-13

申请号：EP97928998

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02 ,  A61B5/055

CPC classification number: A61K49/223 ,  Y10S977/801 ,  Y10S977/927 ,  Y10S977/928 ,  Y10S977/929 ,  Y10S977/93

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：ES2225844T3

公开(公告)日：2005-03-16

申请号：ES95927429

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: SE MUESTRA UN CONTENEDOR QUE INCLUYE UNA SUSPENSION LIPIDICA ACUOSA Y UNA FASE GASEOSA BASICAMENTE SEPARADAS DE LA FASE ESTABILIZANTE ACUOSA, UTIL EN LA VISUALIZACION DIAGNOSTICA COMO LA RESONANCIA ULTRASONICA Y MAGNETICA Y EN APLICACIONES TERAPEUTICAS.

公开(公告)号：CA2200061C

公开(公告)日：2007-04-10

申请号：CA2200061

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： MATSUNAGA TERRY O ,  UNGER EVAN C ,  YELLOWHAIR DAVID

IPC: A61K9/127 ,  G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imagi ng and in therapeutic applications, is disclosed.

公开(公告)号：MX9701969A

公开(公告)日：1998-02-28

申请号：MX9701969

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20 ,  A61K09/127

Abstract: Se describe un recipiente que comprende una suspension acuosa de lípidos y una fase gaseosa que se separa substancialmente de la fase acuosa de estabilizacion,util en formacion de imágenes de diagnostico tales como formacion de imágenes de ultrasonido y resonancia magnética y en aplicaciones terapéuticas.

公开(公告)号：AU3313197A

公开(公告)日：1998-01-07

申请号：AU3313197

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02 ,  A61B5/055

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：DE69738964D1

公开(公告)日：2008-10-16

申请号：DE69738964

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61B5/055 ,  A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：DK0788348T3

公开(公告)日：2004-11-29

申请号：DK95927429

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

公开(公告)号：PT788348E

公开(公告)日：2004-09-30

申请号：PT95927429

申请日：1995-07-26

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  YELLOWHAIR DAVID

IPC: G01R33/28 ,  A61B5/055 ,  A61J1/00 ,  A61K8/04 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K9/133 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B65D81/20

Abstract: A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.

公开(公告)号：AU6188501A

公开(公告)日：2001-10-18

申请号：AU6188501

申请日：2001-08-17

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61B8/13