公开(公告)号：TR199802136T2

公开(公告)日：2001-06-21

申请号：TR9802136

申请日：1997-04-21

Applicant: VERTEX PHARMA

Inventor： ARMISTEAD DAVID M ,  BADIA MICHAEL C ,  BEMIS GUY W ,  BETHIEL RANDY S ,  FRANK CATHARINE A ,  NOVAK PERRY M ,  RONKIN STEVEN M ,  SAUNDERS JEFFREY O

IPC: A61K31/17 ,  A61K31/18 ,  A61K31/404 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61P9/14 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C275/42 ,  C07D263/18 ,  C07D263/32 ,  C07D277/18 ,  C07D413/12 ,  C07C275/28 ,  C07C275/34

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

公开(公告)号：HU0004421A2

公开(公告)日：2001-04-28

申请号：HU0004421

申请日：1997-04-21

Applicant: VERTEX PHARMA

Inventor： ARMISTEAD DAVID M ,  BADIA MICHAEL C ,  BEMIS GUY W ,  BETHIEL RANDY S ,  FRANK CATHARINE A ,  NOVAK PERRY M ,  RONKIN STEVEN M ,  SAUNDERS JEFFREY O

IPC: A61K31/17 ,  A61K31/18 ,  A61K31/404 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61P9/14 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C275/42 ,  C07D263/18 ,  C07D263/32 ,  C07D277/18 ,  C07D413/12

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

公开(公告)号：AU723730B2

公开(公告)日：2000-09-07

申请号：AU2678597

申请日：1997-04-21

Applicant: VERTEX PHARMA

Inventor： ARMISTEAD DAVID M ,  BADIA MICHAEL C ,  BEMIS GUY W ,  BETHIEL RANDY S ,  FRANK CATHARINE A ,  NOVAK PERRY M ,  RONKIN STEVEN M ,  SAUNDERS JEFFREY O

IPC: A61K31/17 ,  A61K31/18 ,  A61K31/404 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61P9/14 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C275/42 ,  C07D263/18 ,  C07D263/32 ,  C07D277/18 ,  C07D413/12 ,  C07C275/28 ,  C07C275/34

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

公开(公告)号：PL329639A1

公开(公告)日：1999-04-12

申请号：PL32963997

申请日：1997-04-21

Applicant: VERTEX PHARMA

Inventor： ARMISTEAD DAVID M ,  BADIA MICHAEL C ,  BEMIS GUY W ,  BETHIEL RANDY S ,  FRANK CATHARINE A ,  NOVAK PERRY M ,  RONKIN STEVEN M ,  SAUNDERS JEFFREY O

IPC: A61K31/17 ,  A61K31/18 ,  A61K31/404 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61P9/14 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C275/42 ,  C07D263/18 ,  C07D263/32 ,  C07D277/18 ,  C07D413/12 ,  C07C275/28 ,  C07C275/34

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.

公开(公告)号：ZA973397B

公开(公告)日：1997-11-14

申请号：ZA973397

申请日：1997-04-21

Applicant: VERTEX PHARMA

Inventor： ARMISTEAD DAVID M ,  BADIA MICHAEL C ,  BEMIS GUY W ,  BETHIEL RANDY S ,  FRANK CATHARINE A ,  NOVAK PERRY M ,  RONKIN STEVEN M ,  SAUNDERS JEFFREY O

IPC: A61K31/17 ,  A61K31/18 ,  A61K31/404 ,  A61K31/42 ,  A61K31/421 ,  A61K31/422 ,  A61P9/14 ,  A61P29/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07C275/42 ,  C07D263/18 ,  C07D263/32 ,  C07D277/18 ,  C07D413/12 ,  C07C ,  C07D ,  A61K

Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as agents for immunosuppression. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.