中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

47 records (took 0.023 seconds)

    Heteroaryl or aryl substituted carboxylic acid or carboxamide derivatives optionally substituted with a sulphonamido group
    10.
    发明专利
    Heteroaryl or aryl substituted carboxylic acid or carboxamide derivatives optionally substituted with a sulphonamido group 未知

    公开(公告)号：NZ502820A

    公开(公告)日：2002-10-25

    申请号：NZ50282098

    申请日：1998-08-27

    Applicant: VERTEX PHARMA

    Inventor： MCCAFFREY PATRICIA ,  NOVAK PERRY M ,  MULLICAN MICHAEL

    IPC: A61K31/4406 ,  A61K31/4427 ,  A61K31/4458 ,  A61K31/4545 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  C07D211/60 ,  C07D213/40 ,  C07D401/12 ,  C07D401/14 ,  A61K31/44 ,  A61K31/445

    Abstract: A compound of the formula (I) and its derivatives can be used, either alone or in conjunction with a neurotrophic factor, such as nerve growth factor, to promote repair of neuronal damage caused by disease or physical trauma, where: A and B are H, Ar, or optionally substituted alkyl, alkenyl or alkynyl, where any one of the CH2 groups of alkyl, alkenyl or alkynyl chains in A or B is optionally replaced by O, S, S(O), S(O)2 OR N(R); Ar is defined in the specification; n is 0 - 2; X is N, O or C(R), when X is N or C(R), Y is H, Ar, or optionally substituted alkyl, alkenyl or alkynyl and when X is O, Y is a lone pair of electrons; R is H, alkyl, alkenyl or alkynyl; K is optionally substituted alkyl, alkenyl or alkynyl, or cyclohexylmethyl, where any one of the CH2 groups of alkyl, alkenyl or alkynyl chains in K is optionally replaced by O, S, S(O), S(O)2 OR N(R); J is H, optionally substituted alkyl, alkenyl or alkynyl, or cyclohexylmethyl D is Ar, or optionally substituted alkyl, alkenyl or alkynyl, or cyclohexylmethyl, where any one of the CH2 groups of alkyl chains in D other than the one that is directly bound to the S(O)2 is optionally replaced by O, S, S(O), S(O)2 OR N(R); and that the compound of formula (I) is not (S)-(2-(5-(dimethylamino)-1-naphthalenesulfanilamido)-3-phenyl)carboxylic acid, 1-(pyridin-4-yl) propyl ester or (S)-(p-toluenesulfanilamido)-3-phenyl-N-(2-pyridin-2-yl)methyl)propionamide; and provided that (i) when X is N, n is 0 and Y is H or alkyl; or (ii) when X is O n is 0; or (iii) when X is C-H, n is 0 and Y is H; then D is Ar, or optionally substituted alkyl, alkenyl or alkynyl, or cyclohexylmethyl, where any one of the CH2 groups of alkyl chains in D other than the one that is directly bound to the S(O)2 is optionally replaced by O, S, S(O), S(O)2 OR N(R).

Patent Agency Ranking