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公开(公告)号：NO327312B1
公开(公告)日：2009-06-08
申请号：NO20032668
申请日：2003-06-12
Applicant: VERTEX PHARMA
Inventor： BADIA MICHAEL C , GRILLOT ANNE-LAURE , CHARIFSON PAUL S , STAMOS DEAN , LIAO YUSHENG , TRUDEAU MARTIN
IPC: C07D235/30 , C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561
Abstract: The present invention relates to compounds of the formula I or a pharmaceutically acceptable derivative thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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公开(公告)号：CZ298463B6
公开(公告)日：2007-10-10
申请号：CZ338098
申请日：1997-04-21
Applicant: VERTEX PHARMA
Inventor： ARMISTEAD DAVID M , BADIA MICHAEL C , BEMIS GUY W , BETHIEL RANDY S , FRANK CATHARINE A , NOVAK PERRY M , RONKIN STEVEN M , SAUNDERS JEFFREY O
IPC: C07D413/12 , A61K31/17 , A61K31/18 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/422 , A61P9/14 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07C275/28 , C07C275/34 , C07C275/42 , C07D263/18 , C07D263/32 , C07D277/18
Abstract: Použití derivátu mocoviny obecného vzorce I, k príprave léciva inhibujícího aktivitu IMPDH u savce,a nekteré takové deriváty mocoviny. Farmaceuticképrostredky obsahující tyto deriváty mocoviny jsouurceny pro lécení nebo prevenci onemocnení zprostredkovaného IMPDH u savce.
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公开(公告)号：AP2003002824A0
公开(公告)日：2003-09-30
申请号：AP2003002824
申请日：2001-12-12
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANNE-LAURE , CHARIFSON PAUL S , STAMOS DEAN , LIAO YUSHENG , BADIA MICHAEL C , TRUDEAU MARTIN
IPC: C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D235/30 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561 , C07D , A61K , A61P
Abstract: The present invention relates to compounds of the formula I: or a pharmaceulically acceptable derivative or prodrug thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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公开(公告)号：NO312963B1
公开(公告)日：2002-07-22
申请号：NO984917
申请日：1998-10-22
Applicant: VERTEX PHARMA
Inventor： ARMISTEAD DAVID M , BADIA MICHAEL C , BEMIS GUY W , BETHIEL RADNY S , FRANK CATHARINE A , NOVAK PERRY M , RONKIN STEVEN M , SAUNDERS JEFFREY O
IPC: A61K31/17 , A61K31/18 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/422 , A61P9/14 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07C275/42 , C07D263/18 , C07D263/32 , C07D277/18 , C07D413/12 , C07C275/28
Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：CA2282398A1
公开(公告)日：1998-09-17
申请号：CA2282398
申请日：1998-03-13
Applicant: VERTEX PHARMA
Inventor： PEARLMAN DAVID A , NOVAK PERRY M , SAUNDERS JEFFREY O , BADIA MICHAEL C , FRANK CATHARINE A , BETHIEL RANDY S , RONKIN STEVEN M , NAEGELE DOUG , ARMISTEAD DAVID M
IPC: C07D277/82 , A61K31/4184 , A61K31/422 , A61K31/423 , A61K31/427 , A61K31/428 , A61P9/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07D235/30 , C07D263/58 , C07D413/12 , C07D417/12 , A61K31/42
Abstract: The present invention relates to a novel class of compounds of formula (I) which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of formula (I) and related compounds, wherein A is a saturated, unsaturated or partially saturated monocyclic or bicyclic ring system optionally comprising up to 4 heteroatoms selected from N, O, and S wherein each A optionally comprises up to 4 substituents selected from R1, R4 and R5; each R1 is halogen, CN, NO2, CF3, OCF3, OH, R3, OR3, 1,2-methylenedioxy, 1,2-ethylenedioxy, SR3, S(O)R3, SO2R3, NH2, NHR3, N(R3)2, NR3R9, COOH, or COOR3; each R2 is independently R1 or a monocyclic ring system consisting of 5 to 6 members per ring, wherein said ring system optionally comprises up to 4 heteroatoms selected from N, O, and S, and wherein a CH2 adjacent to said N, O or S may be substituted with C(O); and each R2 optionally comprises up to 2 substituents, each substituent independently selected from R1.
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Patent Agency Ranking
公开(公告)号：AU2678597A
公开(公告)日：1997-11-12
申请号：AU2678597
申请日：1997-04-21
Applicant: VERTEX PHARMA
Inventor： ARMISTEAD DAVID M , BADIA MICHAEL C , BEMIS GUY W , BETHIEL RANDY S , FRANK CATHARINE A , NOVAK PERRY M , RONKIN STEVEN M , SAUNDERS JEFFREY O
IPC: A61K31/17 , A61K31/18 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/422 , A61P9/14 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07C275/42 , C07D263/18 , C07D263/32 , C07D277/18 , C07D413/12 , C07C275/28 , C07C275/34
Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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公开(公告)号：NO20032668L
公开(公告)日：2003-06-12
申请号：NO20032668
申请日：2003-06-12
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANNE-LAURE , CHARIFSON PAUL S , STAMOS DEAN , LIAO YUSHENG , BADIA MICHAEL C , TRUDEAU MARTIN
IPC: C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D235/30 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561
Abstract: The present invention relates to compounds of the formula I or a pharmaceutically acceptable derivative thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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公开(公告)号：NO20032668A
公开(公告)日：2003-06-12
申请号：NO20032668
申请日：2003-06-12
Applicant: VERTEX PHARMA
Inventor： GRILLOT ANNE-LAURE , CHARIFSON PAUL S , STAMOS DEAN , LIAO YUSHENG , BADIA MICHAEL C , TRUDEAU MARTIN
IPC: C07D235/32 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/4245 , A61K31/437 , A61K31/4412 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , A61P31/00 , A61P31/04 , A61P43/00 , C07D213/00 , C07D221/00 , C07D235/00 , C07D235/30 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/056 , C07D498/04 , C07D521/00 , C07F9/6558 , C07F9/6561
CPC classification number: C07D403/12 , A61K31/00 , A61K31/4184 , A61K31/423 , A61K31/437 , A61K31/4439 , A61K31/4709 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D235/30 , C07D249/08 , C07D263/58 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , C07D471/04 , C07D471/14 , C07D491/04 , C07F9/65583 , C07F9/6561 , Y02A50/393 , Y02A50/473 , A61K2300/00
Abstract: The present invention relates to compounds of the formula I or a pharmaceutically acceptable derivative thereof. The compounds are useful as inhibitors of bacterial gyrase activity. The present invention also relates to methods for treating bacterial infections in mammals. The present invention also relates to methods for decreasing bacterial quantity in a biological sample.
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公开(公告)号：NO20014535A
公开(公告)日：2001-11-19
申请号：NO20014535
申请日：2001-09-18
Applicant: VERTEX PHARMA
Inventor： STAMOS DEAN , TRUDEAU MARTIN , BETHIEL SCOTT , BADIA MICHAEL C , SAUNDERS JEFFREY
IPC: C07D307/20 , A61K31/27 , A61K31/275 , A61K31/341 , A61K31/421 , A61K31/422 , A61K31/454 , A61K31/5377 , A61K31/541 , A61K45/00 , A61P1/18 , A61P9/10 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/02 , A61P43/00 , C07C275/40 , C07C275/42 , C07D263/32 , C07D413/12 , C07D417/12 , C07F9/653
CPC classification number: C07C275/40 , C07B2200/07 , C07C275/42 , C07D263/32 , C07F9/653
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公开(公告)号：OA10902A
公开(公告)日：2001-10-11
申请号：OA9800199
申请日：1998-10-21
Applicant: VERTEX PHARMA
Inventor： ARMISTEAD DAVID M , BADIA MICHAEL C , BETHIEL RANDY S , FRANK CATHARINE A , NOVAK PERRY M , RONKIN STEVEN M , SAUNDERS JEFFREY O
IPC: A61K31/17 , A61K31/18 , A61K31/404 , A61K31/42 , A61K31/421 , A61K31/422 , A61P9/14 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/06 , A61P43/00 , C07C275/42 , C07D263/18 , C07D263/32 , C07D277/18 , C07D413/12 , C07C275/28 , C07C275/34
Abstract: The present invention relates to a novel class of compounds which are IMPDH inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds. The compounds and pharmaceutical compositions of this invention are particularly well suited for inhibiting IMPDH enzyme activity and consequently, may be advantageously used as therapeutic agents for IMPDH mediated processes. This invention also relates to methods for inhibiting the activity of IMPDH using the compounds of this invention and related compounds.
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