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公开(公告)号：JPH07218438A
公开(公告)日：1995-08-18
申请号：JP1012494
申请日：1994-01-31
Applicant: TOA ELECTRONICS , KYOWA MEDEX CO LTD , TOYO BOSEKI
Inventor： TADANO TOSHIO , SUZUKI NORIYUKI , TANEBE MASARU , HANIYU TSUNEO , SAKURAI HISASHI , YOKOYAMA ICHIRO , MORITA TOSHINAO
IPC: G01N33/543 , G01N21/27 , G01N21/76
Abstract: PURPOSE:To determine an object to be measured with high sensitivity by providing an integreting sphere to a detector and arranging a liquid opaque material body having an opening for limiting a reagent applying extent on a porous film. CONSTITUTION:A photometric device S constituted in such a way that a part 3 to be tested is irradiated with light from a light source counterposed to the opening 21 of an integrating sphere and reflected light from the part 3 is introduced to the sphere 2, and then, the reflected light is detected by means of a detector 4 provided on the side face of the sphere 2 is used. Since the reflected light from the part 3 is converged to the detector 4, the quantity of detected light becomes larger and the degree of coloring can be sufficiently recognized, resulting in high-sensitivity measurement. It is preferable to constitute the sphere 2 in such a way that the internal surface is coated with a material having a high reflection efficiency and the opening 21 can be brought nearer to the part 3 as much as possible, and then, the sphere 2 can have such a diameter that does not allow other part than the part 3 to enter the opening 21. In addition a liquid opaque material body having a reagent introducing opening is arranged so as to improve the effectiveness of the device S.
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公开(公告)号：JPH07203995A
公开(公告)日：1995-08-08
申请号：JP2381094
申请日：1994-01-26
Applicant: TOA ELECTRONICS
Inventor： HAKETA YASUSHI , NISHINO TATSUO , TSUNODA HIROSHI
Abstract: PURPOSE:To quickly determine intracellular ATP for microbial examination, etc., in high sensitivity without diluting the specimen by contacting an extracted specimen of intracellular ATP with an agent for suppressing the inhibition of enzymatic reaction and containing cyclodextrin and applying a biochemical luminescent method to the contact product. CONSTITUTION:ATP in a cell is determined in high sensitivity for food sanitation, clinical examination, environmental microbial examination, etc., by contacting a specimen containing cells of microorganisms, etc., with an adenosine triphosphate (ATP) extraction reagent containing a surfactant (e.g. dodecyldimethylbenzyl ammonium chloride) to extract the intracellular ATP of the specimen, contacting the extracted specimen with an agent for suppressing the inhibition of enzymatic reaction and containing a cyclodextrin (alpha- cyclodextrin), adding a luminescent reagent containing luciferin as a fluorescent substrate and luciferase as a luminescent enzyme to the extracted specimen to apply biochemical luminescent method and measuring the light emitted by the biochemical luminescence caused by the enzymatic reaction of luciferin, luciferase and ATP.
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公开(公告)号：JPH07110301A
公开(公告)日：1995-04-25
申请号：JP27897493
申请日：1993-10-12
Applicant: TOA ELECTRONICS
Inventor： HAKETA YASUSHI , NISHINO TATSUO , TSUNODA HIROSHI
Abstract: PURPOSE:To provide a method and apparatus for measuring ATP quantity of cell which enables the ATP (adenosine triphosphate) quantity of cells to be measured with high precision dispensing with the operation of folding a filter membrane after cell trap and not only improving operability but also solving the dangerousness of contamination from outside the filter membrane. CONSTITUTION:A filter membrane 100 which has trapped cells in a specimen is placed in a one-sided open tray container 200 without being folded. The container 200 is injected with an extraction reagent 104 and a luminous reagent to cause biochemical luminous reaction. A photomultiplier tube 108 is installed so as to face the opening of this container 200 to detect the luminous quantity, resulting in measurement of the ATP quantity of cells.
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公开(公告)号：JPH0764517A
公开(公告)日：1995-03-10
申请号：JP21570893
申请日：1993-08-31
Applicant: TOA ELECTRONICS
Inventor： SHIMADA KOICHI
IPC: G02F1/13 , G02F1/136 , G02F1/1368 , G09G3/36
Abstract: PURPOSE:To provide an active matrix array inspection device capable of precisely and easily detecting a defect of an active matrix array where a signal line is short-circuited by a short bus without contacting and accurately specifying a defect detection position also. CONSTITUTION:The short buses of the data signal lines S1, S2, Sn are set at ground potential, and high frequency signals with different frequencies from signal sources OSC1, OSC2, OSCn are supplied to their take-out terminals PS1, PS2, PSn respectively. On the other hand, a bias voltage is applied to a gate signal line of immediately before stage of the gate signal line g2, and a thin film field effect transistor is conducted, and output signals from respective data signal lines are detected from the take-out terminal Pg2 of the gate signal line g2, and after they are amplified by an amplifier AMP, the high frequency signals with the frequencies corresponding to the frequencies of respective signal sources are selected and detected by detection amplifiers F1, F2, Fn respectively. After these detection outputs are summed up by the whole pixels, the defect of the array is discriminated, e.g. by software processing.
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公开(公告)号：JPH06249830A
公开(公告)日：1994-09-09
申请号：JP6287493
申请日：1993-02-26
Applicant: TOA ELECTRONICS
Inventor： NAKANO TAISUKE
IPC: G01N27/49 , G01N27/416
Abstract: PURPOSE:To provide a method for invariably obtaining the correct concentration of the chlorous acid ions continuously in a simple manner, without being affected by the dissolved dioxidized chlorine, even if the pH value of the sample liquid varies, by using the polarography method. CONSTITUTION:Two electrodes consisting of a working electrode 4 and a counter electrode 5 or three electrodes consisting of the working electrode 4, reference electrode 6 and the opposed electrode 5 are immersed in a sample liquid. Relatively moving the working electrode 4 and the sample liquid, the voltage for generating the oxidation electric current of chlorous acid ion is applied on the working electrode 4, having the counter electrode 5 as standard in case of two electrodes, while having the reference electrode 6 as standard in case of three electrodes, and the concentration of the chlorous acid ions in the sample liquid is measured on the basis of the flowing oxidation electric current. Then, the chlorous acid ion concentration is measured, carrying out compensation according to the pH value of the sample liquid for which the concentration of chlorous acid ion is measured separately.
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Patent Agency Ranking
公开(公告)号：JPH06109696A
公开(公告)日：1994-04-22
申请号：JP28530792
申请日：1992-09-30
Applicant: TOA ELECTRONICS , TOTO LTD
Inventor： KATO AKIHIKO , YAMASATO MASAHARU , YANAGIDA YOSHINORI , MATSUNO TAKANORI , OTANI TAKAYUKI
IPC: G01N27/26 , C02F1/46 , G01N27/40 , G01N27/416
Abstract: PURPOSE:To obtain a method and device for easily measuring the pH of electrolytic acid water at a manufacturing site or a usage site such as a hospital and a house. CONSTITUTION:Two pH sensitive electrodes 3 and 4 are laid out at a channel 2 inside a flow cell 1, the pH sensitive electrodes 3 and 4 are calibrated with tap water supplied to the channel 2 as a calibration liquid, and then electrolytic acid water is supplied to only the pH sensitive electrode 4 while the pH sensitive electrode 3 is allowed to contact the tap water. While the tap water and the electrolytic acid water are liquid-joined in the channel, the pH of the electrolytic acid water is measured according to the difference in the potential between two pH sensitive electrodes 3 and 4.
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公开(公告)号：JPH05240831A
公开(公告)日：1993-09-21
申请号：JP7833292
申请日：1992-02-28
Applicant: TOA ELECTRONICS , NIKKISO CO LTD
Inventor： AIZAWA MUTSUO , YAMADA KOJI , NAKAO KATSUHISA
IPC: G01N27/416 , G01N27/48
Abstract: PURPOSE:To measuer the amount of hydrazine in test water accurately without the obstruction of metal ions and to make it possible to perform the stable measurement for a long period by using a polarographic oxidation-reduction current method even if reducing ions such as Fe (II) and the like are present in the test water. CONSTITUTION:In a mixing device 2 of a measuring apparatus, test water from a test-water regulating cell FS1 and electrolyte, wherein EDTA from an electrolyte container 4 is added, are mixed. The EDTA is added into the test water. The test water is injected into a measuring cell 1, wherein a working electrode WE, a counter electrode CE and a comparing electrode RE are provided. The amount of the hydrazine in the test water is measured by a polarographic oxidation-reduction current method. The reducing metal ions such as Fe (II) and the like are masked by the addition of the EDTA. Therefore, the amount of the hydrazine of the test water can be accurately measured without the blocking of the metal ions. Since the metal ions are not attached to the electrodes, deterioration does not occur, and the measurement can be performed stably for a long period.
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公开(公告)号：JPH05133927A
公开(公告)日：1993-05-28
申请号：JP32386191
申请日：1991-11-11
Applicant: TOA ELECTRONICS
Inventor： NAKAMURA YOSHIAKI , IBUKI TADAHIRO , SATO TETSUYA
IPC: G01N27/26 , G01N27/416
Abstract: PURPOSE:To simply and correctly calibrate a pH measuring apparatus with a standard solution which has not been stored in an apparatus memory. CONSTITUTION:A keyboard 19 is used to input a pH-temperature characteristic table of desired standard solution into a microprocessor 15 and this is stored in a RAM 18. Then the standard solution is injected into an appropriate vessel such as a beaker, temperature of the standard solution is measured by an appropriate temperature sensing means, the temperature is converted into a digital signal to be supplied to the microprocessor 15, a pH value of the standard solution corresponding to the measured temperature is taken out from the RAM 18 into the microprocessor 15, and the pH value is used to automatically calibrate a pH measuring apparatus to calculate asymmetry potential, slope, etc. Thus standard solution calibration is always performed correctly even if there is change in temperature.
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公开(公告)号：JPH05133889A
公开(公告)日：1993-05-28
申请号：JP32386391
申请日：1991-11-11
Applicant: TOA ELECTRONICS
Inventor： KUSHISHITAMACHI RYUSUKE
Abstract: PURPOSE:To correct an effect due to the stain of a cell window and thereby to enable stable measurement of turbidity for a long time by providing a light source for correction at equal distances from two light-sensing parts, by detecting the stain of a measuring cell from a difference between sensedlight outputs of a transmitted light and by executing the correction. CONSTITUTION:The scattered light of a light 10 applied to water 21 to be inspected from a light source 1 for measuring turbidity is sensed by photocells 4 and 5 and sensed-light outputs are inputted to a differential amplifier 8. Since a difference between the sensed-light outputs of the photocells 4 and 5 is proportional to the turbidity of the water 21, the turbidity of the water 21 is determined by amplification computation executed in the differential amplifier 8. In the case when a cell window 3 of the photocell 4 is stained, for instance, a light 11 from a light source 2 for correction which is provided at equal distances from the photocells 4 and 5 and lighted alternately with the light source 1 is applied and sensed-light signals of a transmitted light sensed by the photocells 4 and 5 are inputted to a differential amplifier 9. The differential amplifier 9 prepares a correction output for removing the difference between the sensed-light outputs of the photocells 4 and 5, by the amplification computation, and feeds it back to preamplifiers of the photocells 4 and 5 and thereby the sensed-light outputs of the two photocells are corrected.
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公开(公告)号：JPH0530998A
公开(公告)日：1993-02-09
申请号：JP32386291
申请日：1991-11-11
Applicant: TOA ELECTRONICS
Inventor： HAKETA YASUSHI , MOTOHASHI RYOICHI
Abstract: PURPOSE:To carry out a sensitive measurement of intracellular ATP, suitable for a food sanitation test, etc., while reducing inhibition of the enzyme caused by a surfactant by bringing a cell-containing sample into contact with an ATP- extracting reagent and an enzymatic reaction inhibitor and measuring ATP by using the biochemical luminescence method. CONSTITUTION:A cell-containing sample solution 4 is led through a passage 22 for the sample solution to an injector 14 by a pump 10. A carrier solution 3 containing an ATP-extracting reagent for extracting intracellular adenosine triphosphate (ATP) and an enzymatic reaction inhibitor is then led to the injector 14 by a pump 9 so as to be brought into contact with the sample solution 4 for the purpose of extraction of the intracellular ATP. The sample solution 4 is subsequently led through a mixer 17 to a mixing passage 28 where the sample solution 4 is joined with a luciferin and luciferase-containing luminous reagent 2 supplied through a mixer 16 by an injector 13 so as to generate light by a biochemical reaction. The amount of the generated light is detected by a chemiluminescence detector 19 and then compared with data of known concentration samples by using a computer 20, thus measuring the concentration of ATP contained in the sample.
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