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公开(公告)号：PE20211779A1
公开(公告)日：2021-09-08
申请号：PE2021000248
申请日：2019-08-29
Applicant: ARRAY BIOPHARMA INC
Inventor： ALLEN SHELLEY , BARBOUR PATRICK , COOK ADAM , DAHLKE JOSHUA , GAUDINO JOHN , HINKLIN RONALD JAY , LAIRD ELLEN , MCNULTY OREN T , ZHAO QIAN
IPC: A61P35/00 , A61K31/437 , C07D471/04
Abstract: Un compuesto de formula (I) donde X 1 es CH o N; R 1 es hidrogeno o alquilo C1-C6; R 2 es hidrogeno, alquilo C1-C6, entre otros, G es de formula (ii) donde R 8 es Ar 2 , hetAr 2 o alquilo C1-C6; Ar 2 es fenilo opcionalmente sustituido con uno o mas sustituyentes seleccionados independientemente de halogeno, alquilo C1-C2 y alcoxi C1-C2; hetAr 2 es un heteroarilo de 5-6 miembros que tiene 1-2 atomos de nitrogeno en el anillo; El anillo B, incluidos los atomos en los puntos de union, es un carbociclico saturado de 6 miembros opcionalmente sustituido con oxo; R9 es H. Los cuales son inhibidores de una o mas cinasas TAM y/o cinasa c-Met.
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公开(公告)号：SI3227297T1
公开(公告)日：2021-04-30
申请号：SI201531544
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/00 , A61K31/00 , A61P29/00 , A61P37/00
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公开(公告)号：SG11202101148UA
公开(公告)日：2021-04-29
申请号：SG11202101148U
申请日：2019-08-29
Applicant: ARRAY BIOPHARMA INC
Inventor： HINKLIN RONALD JAY , ALLEN SHELLEY , BARBOUR PATRICK , COOK ADAM , DAHLKE JOSHUA , GAUDINO JOHN , LAIRD ELLEN , MCNULTY OREN T , ZHAO QIAN
IPC: A61P35/00 , A61K31/437 , C07D471/04
Abstract: Provided herein are compounds of the Formula I:and stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein R1, R2, R9, X1 and G are as defined herein, which are inhibitors of one or more TAM kinases and/or c-Met kinase, and are useful in the treatment and prevention of diseases which can be treated with a TAM kinase inhibitor and/or a c-Met kinase inhibitor.
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公开(公告)号：AU2015357585B2
公开(公告)日：2020-07-02
申请号：AU2015357585
申请日：2015-12-04
Applicant: ARRAY BIOPHARMA INC , CELGENE CORP
Inventor： ALLEN SHELLEY , BOYS MARK LAURENCE , CHICARELLI MARK J , FELL JAY BRADFORD , FISCHER JOHN P , GAUDINO JOHN , HICKEN ERIK JAMES , HINKLIN RONALD JAY , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , TANG TONY P , BURGESS LAURENCE E , RIEGER ROBERT ANDREW , PHENEGER JED , SATOH YOSHITAKA , LEFTHERIS KATERINA , RAHEJA RAJ K , BENNETT BRYDON L
IPC: C07D487/04 , A61K31/4985 , A61P29/00 , A61P37/00
Abstract: Compounds of Formula I: and stereoisomers and pharmaceutically acceptable salts and solvates thereof in which R
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公开(公告)号：CY1112238T1
公开(公告)日：2015-12-09
申请号：CY111101002
申请日：2011-10-21
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY
IPC: A61K31/4245 , C07D413/00 , C07D417/00
Abstract: Ηεφεύρεσηαυτήαφοράαναστολείςμιτωτικώνκινεσινών, ιδιαιτέρως KSP καιμεθόδουςπαρασκευήςαυτώντωναναστολέων. Ηεφεύρεσηεπίσηςπαρέχειφαρμακευτικέςσυνθέσειςπουπεριλαμβάνουντουςαναστολείςτηςεφεύρεσηςκαιμεθόδουςχρήσηςτωναναστολέωνκαιφαρμακευτικώνσυνθέσεωνστηθεραπείακαιπρόληψηδιαφόρωνδιαταραχών.
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Patent Agency Ranking
公开(公告)号：UA109131C2
公开(公告)日：2015-07-27
申请号：UAA201212901
申请日：2011-04-11
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , BURGESS LAURENCE E , GRONEBERG ROBERT D , HARVEY DARREN M , HUANG LILY , KERCHER TIMOTHY , KRASER CHRISTOPHER F , LAIRD ELLEN , TARLTON EUGENE , ZHAO QIAN
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
Abstract: СоединенияФормулы I: EMBED ISISServer , I иихстереоизомерыи фармацевтическиприемлемыесоли, исольваты, где R1, R2, R3, R4, R5, R6, R7, X1 и X2 имеютзначения, приведенныев описании, являетсяингибиторамиоднойилибольше JAK-кинази пригодныедлялеченияаутоиммунныхзаболеваний, воспалительныхзаболеваний, отторженияпересаженныхорганов, тканейи клеток, атакжегематологическихрасстройстви злокачественныхновообразований, исопутствующихзаболеваний.
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公开(公告)号：AU2015201991A1
公开(公告)日：2015-05-07
申请号：AU2015201991
申请日：2015-04-21
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , BURGESS LAURENCE E , GRONEBERG ROBERT D , HARVEY DARREN M , HUANG LILY , KERCHER TIMOTHY , KRASER CHRISTOPHER F , LAIRD ELLEN , TARLTON EUGENE , ZHAO QIAN
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
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公开(公告)号：CA2606708C
公开(公告)日：2015-01-06
申请号：CA2606708
申请日：2006-05-01
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , ALLEN SHELLEY , LAIRD ELLEN , LYSSIKATOS JOSEPH P , ROBINSON JOHN E , CORRETTE CHRISTOPHER P , DELISLE ROBERT KIRK , VOEGTLI WALTER CHARLES
IPC: C07D417/04 , A61K31/433 , A61K31/437 , C07D285/12 , C07D513/04
Abstract: This invention relates to inhibitors of mitotic kinesins, particularly KSP, and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing the inhibitors and pharmaceutical compositions in the treatment and prevention of various disorders.
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公开(公告)号：SG11201401342VA
公开(公告)日：2014-09-26
申请号：SG11201401342V
申请日：2012-10-09
Applicant: ARRAY BIOPHARMA INC
Inventor： BOYS MARK LAURENCE , BURGESS LAURENCE E , EARY C TODD , GRONEBERG ROBERT , HACHE BRUNO P , HARVEY DARREN , HICKEN ERIK JAMES , KRASER CHRISTOPHER F , LAIRD ELLEN , MORENO DAVID A , MUNSON MARK C , REN LI , ROBINSON JOHN E , SCHLACHTER STEPHEN T
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
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公开(公告)号：CL2014000931A1
公开(公告)日：2014-08-29
申请号：CL2014000931
申请日：2014-04-11
Applicant: ARRAY BIOPHARMA INC
Inventor： MUNSON MARK C , KRASER CHRISTOPHER F , LAIRD ELLEN , ROBINSON JOHN E , BOYS MARK LAURENCE , BURGES LAURENCE E , EARY C TODD , GRONEBERG ROBERT , HACHE BRUNO P , HICKEN ERIK JAMES , MORENO DAVID A , REN LI , SCHLACHTER STEPHEN T , HARVEY DARREN
IPC: C07D487/04 , A61K31/519 , A61P29/00 , A61P37/00
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