公开(公告)号：FI810380L

公开(公告)日：1981-08-14

申请号：FI810380

申请日：1981-02-10

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRANKE ALBRECHT ,  LENKE DIETER ,  LEHMANN HANS DIETER ,  GRIES JOSEF

IPC: C07D413/12 ,  A61K31/495 ,  A61K31/496 ,  A61P9/12 ,  C07D271/10 ,  C07D405/12 ,  C07D

Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.

公开(公告)号：DD146823A5

公开(公告)日：1981-03-04

申请号：DD21693079

申请日：1979-11-15

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF ,  LEHMANN HANS D

IPC: A61K31/55 ,  C07D223/16 ,  C07D405/12

公开(公告)号：DD143257A5

公开(公告)日：1980-08-13

申请号：DD21252279

申请日：1979-04-26

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKE FRITZ-FRIEDER ,  THEOBALD HANS ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08

Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.

公开(公告)号：AU4655679A

公开(公告)日：1979-11-01

申请号：AU4655679

申请日：1979-04-27

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D417/12

Abstract: Alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole and their addition salts with acids, their preparation, and pharmaceutical formulations, containing these compounds, which may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

公开(公告)号：NO791428A

公开(公告)日：1979-10-30

申请号：NO791428

申请日：1979-04-27

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  THEOBALD HANS ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/42 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  C07D261/08 ,  C07D

CPC classification number: C07D261/08

公开(公告)号：FI791255A

公开(公告)日：1979-10-29

申请号：FI791255

申请日：1979-04-18

Applicant: BASF AG

Inventor： THIEME PETER C ,  FRICKEL FRITZ-FRIEDER ,  HAGEN HELMUT ,  FRANKE ALBRECHT ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/41 ,  A61K31/433 ,  A61P9/00 ,  A61P9/06 ,  A61P9/12 ,  C07D285/12 ,  C07D417/12 ,  C07D

Abstract: Alkylaminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole and their addition salts with acids, their preparation, and pharmaceutical formulations, containing these compounds, which may be used for the treatment of coronary diseases of the heart, of hypertonia and of cardiac arrhythmias.

公开(公告)号：MX9203501A

公开(公告)日：1992-09-01

申请号：MX9203501

申请日：1992-06-26

Applicant: BASF AG

Inventor： EHRMANN OSKAR ,  RASCHACK MANFRED ,  GRIES JOSEF ,  KRETZSCHMAR ROLF ,  LEHMANN HANS DIETER ,  FRIEDRICH LUDWIG ,  WUPPERMANN DIRK ,  ZIMMERMANN FRANK ,  SEITZ WERNER

IPC: C07C255/42 ,  A61K31/275 ,  A61K31/277 ,  A61K31/335 ,  A61P9/06 ,  A61P9/10 ,  A61P37/08 ,  C07C253/30 ,  C07C255/32 ,  C07C255/53 ,  C07C255/58 ,  C07D317/06 ,  C07D317/58 ,  C07D317/60 ,  C07D319/02 ,  C07D319/08 ,  C07D319/18 ,  A61K31/33

公开(公告)号：FI86174B

公开(公告)日：1992-04-15

申请号：FI844729

申请日：1984-11-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  VON PHILIPSBORN GERDA ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：ZA885625B

公开(公告)日：1990-04-25

申请号：ZA885625

申请日：1988-07-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SCHLECKER RAINER ,  GRIES JOSEF ,  PHILIPSBORN GERDA VON ,  UNGER LILIANE

IPC: A61K31/135 ,  A61P9/06 ,  A61P25/02 ,  A61K ,  C07C

Abstract: The agents are prepared as described and used for certain groups of patients.

公开(公告)号：ZA8805625B

公开(公告)日：1990-04-25

申请号：ZA8805625

申请日：1988-07-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SCHLECKER RAINER ,  GRIES JOSEF ,  PHILIPSBORN GERDA VON ,  UNGER LILIANE

IPC: A61K31/135 ,  A61P9/06 ,  A61P25/02 ,  A61K ,  C07C

CPC classification number: A61K31/135 ,  Y10S514/821