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公开(公告)号：CA1338939C
公开(公告)日：1997-02-25
申请号：CA527819
申请日：1987-01-21
Applicant: BASF AG
Inventor： WUEST HANS-HEINER , JANSSEN BERND , FRICKEL FRITZ-FRIEDER , NUERRENBACH AXEL
IPC: A61K31/05 , A61K31/047 , A61K31/085 , A61K31/135 , A61K31/16 , A61K31/19 , A61K31/195 , A61K31/215 , A61K31/22 , A61K31/357 , A61K31/36 , A61P17/00 , A61P29/00 , A61P35/00 , C07C27/00 , C07C39/23 , C07C39/42 , C07C41/00 , C07C43/168 , C07C43/20 , C07C43/215 , C07C51/00 , C07C59/125 , C07C59/68 , C07C59/72 , C07C62/38 , C07C67/00 , C07C69/07 , C07C69/157 , C07C69/24 , C07C69/712 , C07C69/78 , C07C213/00 , C07C217/18 , C07D317/50 , C07D325/00
Abstract: Disclosed are new vinylphenol derivatives of the formula I where A is a methylene or ethylene radical which is unsubstituted or substituted by C1-C4-alkyl, R1 and R each hydrogen or methyl, R3 is hydrogen, C1-C4-alkyl, C1-C4-alkoxy or halogen, R4 is hydrogen, C1-C4-alkyl, cyclopropyl or cyclobutyl, R5 and R7 are each hydrogen or -OR8, where R8 is hydrogen, C1-C4-alkyl or C1-C4-alkanoyl, and R6 is hydrogen or is C1-C4-alkyl which is unsubstituted or substituted by carboxyl, C1-C4-alkoxycarbonyl, hydroxyl, C1-C4-alkoxy and/or amino or mono- or di-C1-C4-alkylamino, or is C1-C20-alkanoyl or is benzoyl which is unsubstituted or substituted as described for the C1-C4-alkyl group, or is aralkyl which is unsubstituted or similarly substituted in the aryl moiety, and R6 and R8 together may furthermore form a radical C=O, C=S, -CH2CH2- or CR9R10 , where R9 and R10 are each hydrogen, C1-C4-alkyl or phenyl, and their physiologically tolerated salts. These derivatives are for the treatment of various disorders of the skin, the mucous membranes and the internal organs, and of rheumatic disorder.
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公开(公告)号：CA1330998C
公开(公告)日：1994-07-26
申请号：CA614143
申请日：1989-09-28
Applicant: BASF AG
Inventor： FRICKEL FRITZ-FRIEDER , KUEKENHOEHNER THOMAS , RENDENBACH-MUELLER BEATRICE , WEIFENBACH HARALD , TESCHENDORF HANS-JUERGEN
IPC: A61K31/335 , A61K31/35 , A61K31/40 , A61K31/41 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/47 , A61P25/00 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D419/12
Abstract: An alkoxycoumarin substituted by a heterocyclic radical, of the formula I R1 and R2 independently of one another are each hydrogen, C1-C5-alkyl, trifluoromethyl, phenyl or halogen, or together form a C3-C5-alkylene chain, R3 is C1-C5-alkyl or halogen, n is an integer of from 0 to 3, R4 is hydrogen or C1-C4-alkyl and Het is one of the following heterocyclic radicals: where X is oxygen or sulfur, R5 is unsubstituted or C1C4-alkoxy-substituted C1-C10-alkyl, 5-membered or 6membered oxacycloalkyl, C3-C7-cycloalkyl, benzyl, phenyl which is unsubstituted or substituted by halogen or NO2, a pyridine ring, C1-C5-alkoxycarbonyl or perfluoro-C1-C2-alkyl, R6 is C1-C5-alkyl or C1-C5-alkoxy, R7 is C1-C5-alkyl, unsubstituted or halogen-substituted benzyl or halogen, m is from 0 to 2, R8 is C1-C5-alkyl, C3-C8-cycloalkyl, benzyl or phenyl, R9 is hydrogen or C1-C5-alkyl, R10 is C1C5-alkyl or C1-C8 cycloalkyl, R11 is C1-C5-alkyl, R12 is hydrogen, C1-C5-alkyl or C3-C6-cycloalkyl, R13 is C1-C5-alkyl or halogen, p is from 0 to 2, R14 is C1-C5-alkyl, q is 0 or 1, R15 and R16 are each hydrogen, C1-C5-alkyl or benzyl, R17 is hydrogen or C1-C5-alkyl and R18 is C1-C5-alkyl, with the proviso that R5 is not phenyl when X is oxygen, R1 is methyl and R2 to R4 are each hydrogen, processes for their preparation and drugs prepared therefrom.
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公开(公告)号：AT96151T
公开(公告)日：1993-11-15
申请号：AT89902638
申请日：1989-02-02
Applicant: BASF AG
Inventor： WUEST HANS-HEINER , FRICKEL FRITZ-FRIEDER , PAUST JOACHIM , SCHMIEDER KLAUS , NUERRENBACH AXEL
IPC: A61K31/07 , C07C403/00 , C07D257/04 , A61K7/42
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公开(公告)号：FI84908B
公开(公告)日：1991-10-31
申请号：FI853622
申请日：1985-09-20
Applicant: BASF AG
Inventor： WUEST HANS-HEINER , FRICKEL FRITZ-FRIEDER , NUERRENBACH AXEL
IPC: C07D263/10 , A61K31/015 , A61K31/03 , A61K31/075 , A61K31/085 , A61K31/11 , A61K31/115 , A61K31/12 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/41 , A61P17/00 , A61P29/00 , A61P35/00 , C07C1/00 , C07C13/465 , C07C13/48 , C07C17/00 , C07C25/24 , C07C27/00 , C07C33/38 , C07C39/23 , C07C39/38 , C07C43/168 , C07C43/176 , C07C43/215 , C07C43/23 , C07C45/00 , C07C45/44 , C07C45/68 , C07C47/548 , C07C47/55 , C07C47/57 , C07C47/575 , C07C49/683 , C07C49/747 , C07C49/757 , C07C49/798 , C07C49/813 , C07C49/835 , C07C49/84 , C07C57/50 , C07C57/62 , C07C59/72 , C07C63/66 , C07C63/74 , C07C65/19 , C07C65/28 , C07C65/38 , C07C67/00 , C07C69/157 , C07C69/618 , C07C69/65 , C07C69/734 , C07C69/76 , C07C69/78 , C07C209/00 , C07C209/48 , C07C211/44 , C07C211/52 , C07C215/74 , C07C233/05 , C07C233/11 , C07C233/22 , C07C233/29 , C07C233/65 , C07C235/34 , C07C235/38 , C07C235/42 , C07C255/50 , C07C255/51 , C07C255/54 , C07C255/56 , C07D257/04
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公开(公告)号：NO161972C
公开(公告)日：1989-10-18
申请号：NO853698
申请日：1985-09-20
Applicant: BASF AG
Inventor： WUEST HANS HEINER , FRICKEL FRITZ-FRIEDER , NUERRENBACH AXEL
IPC: C07D233/58 , A61K31/015 , A61K31/025 , A61K31/05 , A61K31/075 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/41 , A61K31/415 , A61K31/445 , A61K31/655 , A61P17/00 , A61P29/00 , A61P35/00 , C07C1/00 , C07C13/48 , C07C17/00 , C07C25/24 , C07C27/00 , C07C33/38 , C07C39/23 , C07C43/14 , C07C43/20 , C07C43/215 , C07C43/23 , C07C43/30 , C07C45/00 , C07C45/44 , C07C45/71 , C07C47/238 , C07C47/27 , C07C47/273 , C07C47/277 , C07C47/548 , C07C47/57 , C07C47/575 , C07C49/225 , C07C49/237 , C07C49/255 , C07C49/798 , C07C49/813 , C07C49/835 , C07C49/84 , C07C57/50 , C07C57/74 , C07C59/54 , C07C65/19 , C07C65/28 , C07C67/00 , C07C69/14 , C07C69/618 , C07C69/76 , C07C209/00 , C07C211/26 , C07C233/00 , C07C233/11 , C07C235/34 , C07C235/38 , C07C239/06 , C07C241/00 , C07C247/22 , C07C247/24 , C07C255/34 , C07C255/37 , C07C255/50 , C07C255/53 , C07C255/54 , C07D257/04 , C07D263/06 , C07D277/24 , C07D295/10 , C07C121/75 , C07C103/22
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Patent Agency Ranking
公开(公告)号：NO162613B
公开(公告)日：1989-10-16
申请号：NO853696
申请日：1985-09-20
Applicant: BASF AG
Inventor： WUEST HANS-HEINER , FRICKEL FRITZ-FRIEDER , NUERRENBACH AXEL
IPC: C07D263/10 , A61K31/015 , A61K31/03 , A61K31/075 , A61K31/085 , A61K31/11 , A61K31/115 , A61K31/12 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/22 , A61K31/275 , A61K31/41 , A61P17/00 , A61P29/00 , A61P35/00 , C07C1/00 , C07C13/465 , C07C13/48 , C07C17/00 , C07C25/24 , C07C27/00 , C07C33/38 , C07C39/23 , C07C39/38 , C07C43/168 , C07C43/176 , C07C43/215 , C07C43/23 , C07C45/00 , C07C45/44 , C07C45/68 , C07C47/548 , C07C47/55 , C07C47/57 , C07C47/575 , C07C49/683 , C07C49/747 , C07C49/757 , C07C49/798 , C07C49/813 , C07C49/835 , C07C49/84 , C07C57/50 , C07C57/62 , C07C59/72 , C07C63/66 , C07C63/74 , C07C65/19 , C07C65/28 , C07C65/38 , C07C67/00 , C07C69/157 , C07C69/618 , C07C69/65 , C07C69/734 , C07C69/76 , C07C69/78 , C07C209/00 , C07C209/48 , C07C211/44 , C07C211/52 , C07C215/74 , C07C233/05 , C07C233/11 , C07C233/22 , C07C233/29 , C07C233/65 , C07C235/34 , C07C235/38 , C07C235/42 , C07C255/50 , C07C255/51 , C07C255/54 , C07C255/56 , C07D257/04 , C07C121/64
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公开(公告)号：NO161910C
公开(公告)日：1989-10-11
申请号：NO853699
申请日：1985-09-20
Applicant: BASF AG
Inventor： WUEST HANS-HEINER , FRICKEL FRITZ-FRIEDER , NUERRENBACH AXEL
IPC: C07C43/20 , A61K31/015 , A61K31/045 , A61K31/075 , A61K31/11 , A61K31/12 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/22 , A61K31/235 , A61K31/275 , A61K31/335 , A61K31/357 , A61K31/41 , A61K31/445 , A61K31/655 , A61P17/00 , A61P29/00 , A61P35/00 , C07C1/00 , C07C13/47 , C07C17/00 , C07C17/26 , C07C25/00 , C07C25/24 , C07C27/00 , C07C35/36 , C07C41/00 , C07C43/188 , C07C43/192 , C07C43/307 , C07C45/00 , C07C45/44 , C07C45/46 , C07C47/548 , C07C47/55 , C07C47/57 , C07C47/575 , C07C49/225 , C07C49/237 , C07C49/683 , C07C49/697 , C07C49/747 , C07C49/757 , C07C49/792 , C07C49/798 , C07C49/813 , C07C49/835 , C07C49/84 , C07C63/66 , C07C65/19 , C07C65/38 , C07C67/00 , C07C69/013 , C07C69/76 , C07C209/00 , C07C233/64 , C07C235/42 , C07C235/84 , C07C241/00 , C07C247/02 , C07C247/24 , C07C253/00 , C07C255/49 , C07C255/50 , C07C255/53 , C07C255/56 , C07D295/04 , C07D317/70 , C07C121/76
Abstract: Tetralin derivatives of the formula I (I) where X, R1, R2 and R3 have the meanings stated in the description, and their preparation are described. The novel compounds are useful for the treatment of disorders.
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公开(公告)号：ZA8507272B
公开(公告)日：1986-05-28
申请号：ZA8507272
申请日：1985-09-23
Applicant: BASF AG
Inventor： FRICKEL FRITZ-FRIEDER , NUERRENBACH AXEL , THYES MARCO
IPC: A61K31/41 , A61P17/00 , A61P29/00 , A61P35/00 , C07D20060101 , C07D257/04 , C07D , A61K
CPC classification number: C07D257/04
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公开(公告)号：NO853697A
公开(公告)日：1986-03-24
申请号：NO853697
申请日：1985-09-20
Applicant: BASF AG
Inventor： WUEST HANS-HEINER , FRICKEL FRITZ-FRIEDER , NUERRENBACH AXEL
IPC: C07F9/09 , A61K20060101 , A61K31/66 , A61P17/00 , A61P29/00 , A61P35/00 , C07F20060101 , C07F9/11 , C07F9/12 , C07F9/24 , C07F9/59 , C07F9/6533 , C07F9/6574 , C07F9/6584 , C07F9/00
CPC classification number: C07F9/094 , C07F9/2429 , C07F9/6533 , C07F9/65742 , C07F9/65842
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公开(公告)号：FI70013B
公开(公告)日：1986-01-31
申请号：FI802960
申请日：1980-09-19
Applicant: BASF AG
Inventor： FRICKEL FRITZ-FRIEDER , FRANKE ALBRECHT , PHILIPSBORN GERDA VON , MUELLER CLAUS D , LENKE DIETER
IPC: A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/47 , A61P9/00 , A61P9/06 , C07C271/22 , C07D207/34 , C07D207/36 , C07D209/42 , C07D401/12 , C07D401/14
Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.
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