公开(公告)号：CA1233465A

公开(公告)日：1988-03-01

申请号：CA469137

申请日：1984-12-03

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  VON PHILIPSBORN GERDA ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12 ,  C07D207/335

Abstract: Aminopropanol derivatives of the formula I where R1 and R2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R1 and R2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and- is thien-2-yl, thien-3-yl, pyrid-2-yl, pyrid-3-yl, pyrid-4-yl, fur-2-yl, 1-alkylpyrr-2-yl, 1-alkylpyrr-3-yl or 1-alkylpyrazol-4 yl, alkyl being of 1 to 3 carbon atoms, and their physiologically tolerated addition salts with acids, processes for their preparation, and antiarrhythmic agents containing these compounds.

公开(公告)号：FI862314A0

公开(公告)日：1986-05-30

申请号：FI862314

申请日：1986-05-30

Applicant: BASF AG

Inventor： HEGE HANS-GUENTHER ,  EISEN GERHARD ,  KOENIG HORST ,  VON PHILIPSBORN GERDA

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/4418 ,  A61P9/06 ,  C07D213/66 ,  C07D491/04 ,  C07D491/048 ,  C07D

公开(公告)号：CA1155851A

公开(公告)日：1983-10-25

申请号：CA365857

申请日：1980-12-01

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  VON PHILIPSBORN GERDA ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/4433 ,  A61K31/445 ,  A61P9/06 ,  C07D333/38 ,  C07D409/12 ,  C07D211/06

Abstract: O.Z. 0050/034,178 Substituted piperidinoalkyl ethers of 3-hydroxy-thiophene-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and which may be used in the treatment of cardiac arrhythmias.

公开(公告)号：CA1155124A

公开(公告)日：1983-10-11

申请号：CA361718

申请日：1980-10-07

Applicant: BASF AG

Inventor： FRICKEL FRITZ-FRIEDER ,  FRANKE ALBRECHT ,  VON PHILIPSBORN GERDA ,  MUELLER CLAUS D ,  LENKE DIETER

IPC: A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/454 ,  A61K31/47 ,  A61P9/00 ,  A61P9/06 ,  C07C271/22 ,  C07D207/34 ,  C07D207/36 ,  C07D209/42 ,  C07D401/12 ,  C07D401/14 ,  C07D401/00

Abstract: Substituted piperidinoalkyl ethers of 4,5-dialkyl-3-hydroxy-pyrrole-2-carboxylic acid esters and their physiologically tolerated addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：CA1108148A

公开(公告)日：1981-09-01

申请号：CA299068

申请日：1978-03-16

Applicant: BASF AG

Inventor： VON PHILIPSBORN GERDA ,  BOELL WALTER ,  LENKE DIETER

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056

Abstract: New pyridinyl aminoalkyl ethers, their N-oxides and their physiologically acceptable addition salts with acids, processes for their preparation and pharmaceutical formulations which contain these compounds and are useful in the treatment of cardiac arrhythmias.

公开(公告)号：FI86174C

公开(公告)日：1992-07-27

申请号：FI844729

申请日：1984-11-30

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  SPIEGLER WOLFGANG ,  SIEGEL HARDO ,  MUELLER CLAUS D ,  VON PHILIPSBORN GERDA ,  LENKE DIETER ,  GRIES JOSEF

IPC: A61K31/34 ,  A61K31/341 ,  A61K31/38 ,  A61K31/381 ,  A61K31/40 ,  A61K31/41 ,  A61K31/415 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4406 ,  A61K31/4409 ,  A61K31/4418 ,  A61K31/495 ,  A61P9/06 ,  C07D207/32 ,  C07D207/333 ,  C07D213/50 ,  C07D231/12 ,  C07D307/46 ,  C07D333/22 ,  C07D409/12

公开(公告)号：FI84827B

公开(公告)日：1991-10-15

申请号：FI862314

申请日：1986-05-30

Applicant: BASF AG

Inventor： HEGE HANS-GUENTHER ,  EISEN GERHARD ,  KOENIG HORST ,  VON PHILIPSBORN GERDA

IPC: C07D213/65 ,  A61K31/44 ,  A61K31/4418 ,  A61P9/06 ,  C07D213/66 ,  C07D491/04 ,  C07D491/048

公开(公告)号：FI74962C

公开(公告)日：1988-04-11

申请号：FI780842

申请日：1978-03-17

Applicant: BASF AG

Inventor： VON PHILIPSBORN GERDA ,  BOELL WALTER ,  LENKE DIETER

IPC: A61C8/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4406 ,  A61K31/4415 ,  A61K31/4418 ,  A61K31/4427 ,  A61K31/445 ,  A61K31/455 ,  A61K31/495 ,  A61K31/496 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  C07D213/127 ,  C07D213/65 ,  C07D213/66 ,  C07D213/67 ,  C07D213/79 ,  C07D213/80 ,  C07D221/04 ,  C07D263/32 ,  C07D401/12 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D491/056

公开(公告)号：CS236489B2

公开(公告)日：1985-05-15

申请号：CS666882

申请日：1982-09-16

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MUELLER JOSEF ,  LIETZ HELMUT ,  WIERSDORF WALTER-WIELANT ,  HEGE HANS-GUENTHER ,  MUELLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  VON PHILIPSBORN GERDA ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C97/10 ,  C07C93/06 ,  C07D295/10 ,  C07D341/12 ,  A61K31/135 ,  A61K31/395

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

公开(公告)号：FI823217L

公开(公告)日：1983-03-19

申请号：FI823217

申请日：1982-09-17

Applicant: BASF AG

Inventor： FRANKE ALBRECHT ,  MYLLER JOSEF ,  LIETZ HELMUT ,  WIERSDORFF WALTER-WIELANT ,  HEGE HANS-GYNTHER ,  MYLLER CLAUS D ,  GRIES JOSEF ,  LENKE DIETER ,  VON PHILIPSBORN GERDA ,  RASCHACK MANFRED

IPC: A61K31/13 ,  A61K31/445 ,  A61K31/495 ,  C07C45/62 ,  C07C45/71 ,  C07C45/73 ,  C07C45/74 ,  C07C49/83 ,  C07C49/835 ,  C07C49/84 ,  C07D211/46 ,  C07D211/52 ,  C07D295/08 ,  C07D295/092 ,  C07D303/22 ,  C07D303/24 ,  C07C

Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.