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公开(公告)号：DK164699C
公开(公告)日：1992-12-21
申请号：DK416082
申请日：1982-09-17
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , MUELLER JOSEF , LIETZ HELMUT , WIERSDORFF WALTER-WIELANT , HEGE HANS-GUENTHER , MUELLER CLAUS D , GRIES JOSEF , LENKE DIETER , PHILIPSBORN GERDA VON , RASCHACK MANFRED
IPC: A61K31/13 , A61K31/445 , A61K31/495 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/08 , C07D295/092 , C07D303/22 , C07D303/24 , C07C217/36 , C07C323/25 , C07D207/08 , C07D211/14 , C07D295/088
Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
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公开(公告)号：AU611113B2
公开(公告)日：1991-06-06
申请号：AU8240387
申请日：1987-12-10
Applicant: BASF AG
Inventor： SEITZ WERNER , UNGER LILIANE , RASCHACK MANFRED , BALDINGER VERENA , RUEBSAMEN KLAUS , GRIES JOSEF
IPC: A61K31/275 , A61K31/335 , A61K31/357 , A61K31/36 , A61P1/04 , A61P3/00 , A61P9/00 , A61P11/00 , A61P43/00 , C07C67/00 , C07C253/00 , C07C253/30 , C07C255/32 , C07C255/33 , C07C255/35 , C07C255/37 , C07C255/42 , C07C255/53 , C07C255/58 , C07D317/50 , C07D317/60 , C07D319/08 , C07D319/18 , C07D321/00 , C07C121/80 , C07C121/78
Abstract: Basic-substituted phenylacetonitriles of the formula I … … in which… R to R and n have the meaning given in the description, are suitable for combating diseases.
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公开(公告)号：DK158979C
公开(公告)日：1991-01-07
申请号：DK566684
申请日：1984-11-29
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , SPIEGLER WOLFGANG , SIEGEL HARDO , MUELLER CLAUS D , PHILIPSBORN GERDA VON , LENKE DIETER , GRIES JOSEF
IPC: A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4418 , A61K31/495 , A61P9/06 , C07D207/32 , C07D207/333 , C07D213/50 , C07D231/12 , C07D307/46 , C07D333/22 , C07D409/12
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公开(公告)号：FI81347B
公开(公告)日：1990-06-29
申请号：FI852730
申请日：1985-07-10
Applicant: BASF AG
Inventor： GEISS KARL-HEINZ , SCHMIED BERNHARD , RASCHACK MANFRED , LEHMANN HANS-DIETER , GRIES JOSEF , RUEBSAMEN KLAUS
IPC: A61K31/50 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/04 , A61P9/12 , C07D237/00 , C07D403/04 , C07D403/10
Abstract: Novel pyrrol-1-ylphenyldihydropyridazinones of the formula I their preparation and their use in the treatment of disorders.
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公开(公告)号：DK156513C
公开(公告)日：1990-02-05
申请号：DK159882
申请日：1982-04-07
Applicant: BASF AG
Inventor： EHRMANN OSKAR , RASCHACK MANFRED , GRIES JOSEF , KRETZSCHMAR ROLF , LEHMANN HANS DIETER , FRIEDRICH LUDWIG , MUELLER CLAUS D , FRANK WOLFRAM , WUPPERMANN DIRK , ZIMMERMANN FRANK , SEITZ WERNER , TREIBER HANS JOERG , DENGEL FERDINAND , KURBJUWEIT HANS-GEORG
IPC: C07C255/42 , A61K31/275 , A61K31/277 , A61K31/335 , A61P9/06 , A61P9/10 , A61P37/08 , C07C253/30 , C07C255/32 , C07C255/53 , C07C255/58 , C07D317/06 , C07D317/58 , C07D317/60 , C07D319/02 , C07D319/08 , C07D319/18 , C07C121/75 , C07D319/00
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Patent Agency Ranking
公开(公告)号：FI77224B
公开(公告)日：1988-10-31
申请号：FI823217
申请日：1982-09-17
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , MUELLER JOSEF , LIETZ HELMUT , WIERSDORFF WALTER-WIELANT , HEGE HANS-GUENTHER , MUELLER CLAUS D , GRIES JOSEF , LENKE DIETER , VON PHILIPSBORN GERDA , RASCHACK MANFRED
IPC: A61K31/13 , A61K31/445 , A61K31/495 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/08 , C07D295/092 , C07D303/22 , C07D303/24 , C07C93/06 , C07C93/14 , C07C97/10 , C07C149/24 , C07D207/06 , C07D207/12 , C07D211/14 , C07D211/40
Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
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公开(公告)号：DK150602C
公开(公告)日：1987-12-07
申请号：DK175179
申请日：1979-04-27
Applicant: BASF AG
Inventor： THIEME PETER C , FRICKEL FRITZ-FRIEDER , THEOBALD HANS , FRANKE ALBRECHT , LENKE DIETER , GRIES JOSEF
Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.
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公开(公告)号：CA1229597A
公开(公告)日：1987-11-24
申请号：CA445508
申请日：1984-01-18
Applicant: BASF AG
Inventor： ROSSY PHILLIP A , THYES MARCO , FRANKE ALBRECHT , KOENIG HORST , LEHMANN HANS D , GRIES JOSEF , FRIEDRICH LUDWIG , LENKE DIETER
IPC: A61K31/50 , A61K31/502 , A61K31/535 , A61K31/55 , A61P1/04 , A61P7/02 , A61P9/12 , C07D237/04 , C07D237/14 , C07D237/26 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , C07D521/00 , C07D237/00
Abstract: This invention relates to the preparation of novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula (I) where the substituents on the phenylene radical are meta or para to one another, A and B are each hydrogen or together form a bond, R1 and R2 are each hydrogen or C1-C3-alkyl, or, where A and B are hydrogen, together form a C1-C4-alkylene radical, R3 is straight-chain C1-C4 alkylene which can be substituted by 1 or 2 C1-C5-alkyl groups, and R4 is a) pyrrol-1-yl, imidazol-1-yl, pyrazol-1-yl of 1,2,4triazol-1-yl, or b) a group of the formula II (II) c) a group of the formula III (III) d) a group of the formula IV -NR10R11 (IV) e) a group of the formula V (V) f) a group of the formula VI (VI) These compounds inhibit thrombocyte aggregation and gastric secretion and have hypotensive and positively inotropic properties.
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公开(公告)号：NO155771C
公开(公告)日：1987-05-27
申请号：NO823161
申请日：1982-09-17
Applicant: BASF AG
Inventor： FRANKE ALBRECHT , MUELLER JOSEF , LIETZ HELMUT , WIERSDORFF WALTER-WIELANT , HEGE HANS-GUENTHER , MUELLER CLAUS D , GRIES JOSEF , LENKE DIETER , PHILIPSBORN GERDA VON , RASCHACK MANFRED
IPC: A61K31/13 , A61K31/445 , A61K31/495 , C07C45/62 , C07C45/71 , C07C45/73 , C07C45/74 , C07C49/83 , C07C49/835 , C07C49/84 , C07D211/46 , C07D211/52 , C07D295/08 , C07D295/092 , C07D303/22 , C07D303/24 , C07C97/10
Abstract: Novel aminopropanol derivatives of 2-hydroxy- beta -phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
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公开(公告)号：DK150602B
公开(公告)日：1987-04-13
申请号：DK175179
申请日：1979-04-27
Applicant: BASF AG
Inventor： THIEME PETER C , FRICKEL FRITZ-FRIEDER , THEOBALD HANS , FRANKE ALBRECHT , LENKE DIETER , GRIES JOSEF
Abstract: Alkylamino-propanol derivatives of 3-alkyl-5-(2-hydroxystyryl)-isoxazole, of the general formula where R is hydrogen, alkyl of 1 to 8 carbon atoms, which is unsubstituted or substituted by hydroxyl, alkoxy of 1 to 3 carbon atoms or cycloalkyl with 3 to 8 carbon atoms in the ring, alkenyl or alkynyl of 2 to 8 carbon atoms, or cycloalkyl with 3 to 8 carbon atoms in the ring, the cycloalkyl rings being unsubstituted or mono- or di-substituted by alkyl of 1 to 3 carbon atoms, and R' is alkyl of 1 to 4 carbon atoms, and their addition salts with physiologically acceptable acids, their preparation, and pharmaceutical formulations which contain these compounds and which can be used as valuable drugs in the treatment of hypertonia, coronary diseases of the heart and cardiac arrhythmias.
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