公开(公告)号：CA1171412A

公开(公告)日：1984-07-24

申请号：CA404625

申请日：1982-06-07

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04

Abstract: 2-Aryl-3,4-diazabicycis ¢4.n.O!alk-2-en-5-ones of the formula I I where m, n, R, R1, R2 anc R3 have the meanings given, are useful for treating high blood pressure and thromoembolic disorders.

公开(公告)号：FI840224A

公开(公告)日：1984-07-23

申请号：FI840224

申请日：1984-01-19

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LEHMANN HANS DIETER ,  GRIES JOSEF ,  FRIEDRICH LUDWIG ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/502 ,  A61K31/535 ,  A61K31/55 ,  A61P1/04 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04 ,  C07D237/14 ,  C07D237/26 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/14 ,  C07D521/00 ,  C07D

Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula (I) where R1, R2, R3, R4, A and B have the meanings given in the description, and their preparation are described. The compounds have thrombocyte aggregation-inhibiting activity.

公开(公告)号：CA1163268A

公开(公告)日：1984-03-06

申请号：CA379001

申请日：1981-06-04

Applicant: BASF AG

Inventor： THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  LENKE DIETER ,  LEHMANN HANS D ,  GRIES JOSEF

IPC: A61K31/50 ,  C07D237/04 ,  C07D237/14

Abstract: O.Z. 0050/034,503/034,645 Novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are substituted in the pposition of the phenyl ring by a carbamate or thiocarbamate group, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders, and as anti-hypertensives.

公开(公告)号：CA1161437A

公开(公告)日：1984-01-31

申请号：CA379071

申请日：1981-06-04

Applicant: BASF AG

Inventor： THYES MARCO ,  KOENIG HORST ,  LENKE DIETER ,  LEHMANN HANS D ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: 0050/034502 Novel 6-(p-acylaminophenyl)-4,5-dihydro-3(2H)-pyridazinones, whose acyl radical is derived from a cycloalkylcarboxylic acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders and as anti-hypertensives.

公开(公告)号：ZA8208127B

公开(公告)日：1983-10-26

申请号：ZA8208127

申请日：1982-11-05

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22 ,  A61K ,  C07D

CPC classification number: C07D237/22 ,  C07D237/20

公开(公告)号：ZA8204438B

公开(公告)日：1983-05-25

申请号：ZA8204438

申请日：1982-06-23

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  A61K ,  C07C

CPC classification number: C07D215/227 ,  C07D209/34 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04

公开(公告)号：NO823682L

公开(公告)日：1983-05-09

申请号：NO823682

申请日：1982-11-05

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22 ,  C07D

公开(公告)号：DK492282A

公开(公告)日：1983-05-07

申请号：DK492282

申请日：1982-11-05

Applicant: BASF AG

Inventor： KROPP RUDOLF ,  THYES MARCO ,  SCHLECKER RAINER ,  FRANKE ALBRECHT ,  REICHENEDER FRANZ ,  AMANN AUGUST ,  TESCHENDORF HANS-JUERGEN ,  KRETZSCHMAR ROLF ,  TRAUT MARTIN ,  GRIES JOSEF

IPC: A61K31/50 ,  A61P9/02 ,  A61P25/00 ,  A61P25/24 ,  A61P25/26 ,  C07D237/20 ,  C07D237/22 ,  C07D

公开(公告)号：AU8515382A

公开(公告)日：1983-01-13

申请号：AU8515382

申请日：1982-06-23

Applicant: BASF AG

Inventor： ROSSY PHILLIP A ,  THYES MARCO ,  FRANKE ALBRECHT ,  KOENIG HORST ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/55 ,  A61P7/02 ,  A61P9/12 ,  C07D209/34 ,  C07D215/22 ,  C07D215/227 ,  C07D223/16 ,  C07D401/04 ,  C07D403/04 ,  C07D401/10 ,  C07D403/10

Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I I where m and n are identical or different and each is 1, 2 or 3, and R, R1 and R2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.

公开(公告)号：CA1108614A

公开(公告)日：1981-09-08

申请号：CA305625

申请日：1978-06-16

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  THYES MARCO ,  KOENIG HORST ,  LEHMANN HANS D ,  GRIES JOSEF ,  LENKE DIETER ,  KUNZE JOHANNES

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: O.Z. 32,647 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or .beta.-haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutlc agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or .alpha.-haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thrombo-embolic disorders.