公开(公告)号：DK149590B

公开(公告)日：1986-08-04

申请号：DK532679

申请日：1979-12-14

Applicant: BASF AG

Inventor： THYES MARCO ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  KUNZE JOHANNES ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  C07D403/10

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：CA1145749A

公开(公告)日：1983-05-03

申请号：CA341754

申请日：1979-12-12

Applicant: BASF AG

Inventor： THYES MARCO ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER ,  KUNZE JOHANNES

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  C07D403/10 ,  C07D207/30

Abstract: O.Z. 0050/033576 2-Aryl-3,4-diaza-bicyclo-¢4.1.0!hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：CA1108614A

公开(公告)日：1981-09-08

申请号：CA305625

申请日：1978-06-16

Applicant: BASF AG

Inventor： LEBKUECHER ROLF ,  THYES MARCO ,  KOENIG HORST ,  LEHMANN HANS D ,  GRIES JOSEF ,  LENKE DIETER ,  KUNZE JOHANNES

IPC: C07D237/00 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07D237/04

Abstract: O.Z. 32,647 6-(p-Acylaminophenyl)-4,5-dihydropyridaz-3-ones of the formula I I where R1 is hydrogen or alkyl of 1 to 3 carbon atoms and R2, if R1 is hydrogen, is halogen-substituted alkyl of 3 to 6 carbon atoms or .beta.-haloethyl or, if R1 is alkyl of 1 to 3 carbon atoms, is halogen-substituted alkyl of 1 to 6 carbon atoms, their manufacture, and therapeutlc agents which contain, as the active ingredient, a compound of the formula I, where R2 may also be halomethyl or .alpha.-haloethyl if R1 is hydrogen. These compounds may be used as anti-hypertensive agents and for the prophylaxis and therapy of thrombo-embolic disorders.

公开(公告)号：DK149590C

公开(公告)日：1987-02-09

申请号：DK532679

申请日：1979-12-14

Applicant: BASF AG

Inventor： THYES MARCO ,  GRIES JOSEF ,  LEHMANN HANS DIETER ,  KUNZE JOHANNES ,  LENKE DIETER

IPC: A61K31/50 ,  A61K31/395 ,  A61K31/502 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  C07D403/10

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.

公开(公告)号：HU182454B

公开(公告)日：1984-01-30

申请号：HUBA003905

申请日：1979-12-14

Applicant: BASF AG

Inventor： THYES MARCO ,  GRIES JOSEF ,  LEHMANN HANS D ,  LENKE DIETER ,  KUNZE JOHANNES

IPC: A61K31/395 ,  A61K31/502 ,  A61K31/50 ,  A61P7/02 ,  A61P9/12 ,  C07C62/38 ,  C07C205/56 ,  C07D231/54 ,  C07D237/26 ,  C07D403/10

Abstract: 2-Aryl-3,4-diaza-bicyclo-[4.1.0]hept-2-en-5-ones, substituted in the phenyl ring, of the general formula their preparation, and therapeutic agents, containing these compounds, which may be used for the treatment of hypertension or of thrombo-embolic disorders.