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公开(公告)号:US08883645B2
公开(公告)日:2014-11-11
申请号:US13941240
申请日:2013-07-12
Applicant: California Institute of Technology
Inventor: Chieh-Feng Chang , Aditya Rajagopal , Axel Scherer
IPC: H01L21/311 , H01L29/66 , H01L29/423 , H01L29/06
CPC classification number: H01L29/66477 , H01L29/0673 , H01L29/4232
Abstract: Methods for fabrication of nanopillar field effect transistors are described. These transistors can have high height-to-width aspect ratios and be CMOS compatible. Silicon nitride may be used as a masking material. These transistors have a variety of applications, for example they can be used for molecular sensing if the nanopillar has a functionalized layer contacted to the gate electrode. The functional layer can bind molecules, causing an electrical signal in the transistor.
Abstract translation: 描述了纳米柱场效应晶体管的制造方法。 这些晶体管可以具有高的高宽比和CMOS兼容性。 氮化硅可以用作掩模材料。 这些晶体管具有各种应用,例如,如果纳米柱具有与栅电极接触的功能化层,则它们可用于分子感测。 功能层可以结合分子,在晶体管中引起电信号。
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公开(公告)号:US20140322489A1
公开(公告)日:2014-10-30
申请号:US14218872
申请日:2014-03-18
Applicant: California Institute of Technology
Inventor: Marc A. Unger , Hou-Pu Chou , Todd A. Thorsen , Axel Scherer , Stephen R. Quake
IPC: F16K13/00
CPC classification number: B29C51/00 , B01L3/502707 , B01L3/50273 , B01L3/502738 , B01L2300/0861 , B01L2300/0887 , B01L2300/123 , B01L2400/046 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , B81B5/00 , B81B2201/036 , B81B2201/054 , B81C1/00119 , B81C2201/019 , B81C2201/034 , C12Q1/6874 , F04B43/043 , F15C1/06 , F15C5/00 , F16K11/20 , F16K13/00 , F16K31/126 , F16K99/0001 , F16K99/0015 , F16K99/0046 , F16K99/0048 , F16K99/0051 , F16K99/0059 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/008 , F16K2099/0094 , Y10T137/0491 , Y10T137/0497 , Y10T137/2224 , Y10T137/87249 , Y10T156/10 , Y10T428/24479 , Y10T428/24744 , C12Q2535/125
Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.
Abstract translation: 一种制造弹性体结构的方法,包括:在第一微加工模具的顶部上形成第一弹性体层,所述第一微加工模具具有形成沿所述第一弹性体层的底表面延伸的第一凹槽的第一凸起突起; 在第二微加工模具的顶部上形成第二弹性体层,所述第二微加工模具具有第二凸起突起,所述第二凸起突起形成沿所述第二弹性体层的底表面延伸的第二凹槽; 将第二弹性体层的底表面粘合到第一弹性体层的顶表面上,使得控制通道在第一和第二弹性体层之间的第二凹部中形成; 以及将第一弹性体层定位在平面基底的顶部上,使得流动通道在第一弹性体层和平面基底之间的第一凹部中形成。
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公开(公告)号:US20130327645A1
公开(公告)日:2013-12-12
申请号:US13967108
申请日:2013-08-14
Applicant: California Institute of Technology
Inventor: Sameer Walavalkar , Axel Scherer , Thomas A. Tombrello , Aditya Rajagopal , Andrew P. Homyk , Erika Garcia
IPC: G01N27/447
CPC classification number: G01N27/447 , B82Y30/00 , C12Q1/6869 , G01N33/48721 , C12Q2563/116 , C12Q2565/631
Abstract: Methods and devices for sequencing nucleic acids are disclosed herein. Devices are also provided herein for measuring DNA with nano-pores sized to allow DNA to pass through the nano-pore. The capacitance can be measured for the DNA molecule passing through the nano-pore. The capacitance measurements can be correlated to determine the sequence of base pairs passing through the nano-pore to sequence the DNA.
Abstract translation: 本文公开了用于测序核酸的方法和装置。 本文还提供了用于测量具有大小允许DNA穿过纳米孔的纳米孔的DNA的装置。 可以测量通过纳米孔的DNA分子的电容。 电容测量可以相关,以确定通过纳米孔的碱基对序列来对DNA进行排序。
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公开(公告)号:US12168797B2
公开(公告)日:2024-12-17
申请号:US18352112
申请日:2023-07-13
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor: Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N33/48 , C12Q1/68 , C12Q1/6825 , C12Q1/6851 , G01N21/64 , G01N33/50 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10 , G06F17/11 , G16B40/00
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号:US20240167092A1
公开(公告)日:2024-05-23
申请号:US18128764
申请日:2023-03-30
Applicant: California Institute of Technology
Inventor: Emil P. Kartalov , Aditya Rajagopal , Axel Scherer , Mark D. Goldberg
IPC: C12Q1/6883 , C12Q1/68 , C12Q1/6851 , C12Q1/70
CPC classification number: C12Q1/6883 , C12Q1/68 , C12Q1/6851 , C12Q1/701 , C12Q1/703 , C12Q2600/156 , Y10T436/143333
Abstract: FRET-based analytes detection and related methods and systems are described where a pair of FRET labeled primers and/or oligonucleotides are used that are specific for target sequences located at a distance up to four time the Forster distance of the FRET chromophores presented on the FRET labeled primers and/or oligonucleotides one with respect to the other in one or more polynucleotide analyte; in particular the pair of FRET labeled primers and/or oligonucleotides is combined with a sample and subjected to one or more polynucleotide amplification reactions before measuring FRET signals from at least one FRET chromophore.
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公开(公告)号:US20240125819A1
公开(公告)日:2024-04-18
申请号:US18377547
申请日:2023-10-06
Applicant: California Institute of Technology , TotalEnergies OneTech
Inventor: Axel Scherer , John Richard Ordonez-Varela , Samson CHEN , Pasha RESHETIKHIN
Abstract: The present disclosure is directed toward systems and methods for measuring electric current in a multi-wire cable, as well as the apparent and real power associated with an electrical load connected to the cable. A probe comprising an array of small form-factor, high-speed magnetometers is operatively coupled with the cable such that the magnetometers partially surround the cable. Each magnetometer detects the composite magnetic field at its location, and this plurality of measurements is used to generate a magnetic-field map. The contributions of the current flow in each wire are identified by deconvolving the magnetic-field map, enabling their locations to be determined and monitoring of the current and power flow. A sensor included in the probe is used to determine the phase of the applied voltage. The phase difference between the voltage and current is then used to determine the real power dissipation of the load.
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公开(公告)号:US11903708B2
公开(公告)日:2024-02-20
申请号:US16144174
申请日:2018-09-27
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor: Samson Chen , Axel Scherer , Muhammad Musab Jilani , Xiomara L. Madero
IPC: A61B5/1486 , A61B5/1459 , G01N27/419 , G01N27/30 , A61B5/145
CPC classification number: A61B5/14865 , A61B5/1459 , A61B5/14532 , G01N27/30 , G01N27/419
Abstract: A sensor implanted in tissues and including a sensing enzyme takes an electrical measurement and compares it to reference curves for the voltage current relationship. The sensor determines whether molecular compounds are present which interfere with the detection of the molecule of interest. If interfering species are found, the measurement voltage is set in a low range to reduce errors, while if the interfering species are not found, the measurement voltage is set in a high range to increase the detected signal.
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公开(公告)号:US11827921B2
公开(公告)日:2023-11-28
申请号:US16864744
申请日:2020-05-01
Applicant: California Institute of Technology
Inventor: Emil P. Kartalov , Aditya Rajagopal , Axel Scherer
IPC: G01N33/48 , G01N33/50 , C12Q1/6825 , G16B25/00 , G16B5/00 , C12Q1/6851 , G16B25/20 , G16B40/10 , C12Q1/68 , G01N21/64 , G06F17/10 , G06F17/11 , G16B40/00
CPC classification number: C12Q1/6825 , C12Q1/68 , C12Q1/6851 , G01N21/6486 , G16B5/00 , G16B25/00 , G16B25/20 , G16B40/10 , G06F17/10 , G06F17/11 , G16B40/00 , Y02A50/30 , C12Q1/6851 , C12Q2537/101 , C12Q2537/143 , C12Q2537/165 , C12Q2563/107
Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.
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公开(公告)号:US11629996B2
公开(公告)日:2023-04-18
申请号:US17675575
申请日:2022-02-18
Applicant: California Institute of Technology
Inventor: Axel Scherer , Taeyoon Jeon
Abstract: An infrared spectrometer for operation in the mid-infrared spectral range is presented, where the spectrometer includes a Bragg-mirror-based spectral filter that is operative for providing an interrogation signal whose spectral content is dispersed along a first direction at a filter aperture. The filter aperture is imaged through a sample by a thermal-imaging camera to create a focused image that is based on the interrogation signal and the absorption characteristics of the sample. As a result, embodiments in accordance with the present disclosure can be smaller, less complex, and less expensive than infrared spectrometers known in the prior art.
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公开(公告)号:US11619577B2
公开(公告)日:2023-04-04
申请号:US17864246
申请日:2022-07-13
Applicant: California Institute of Technology
Inventor: Axel Scherer , Amirhossein Nateghi , Taeyoon Jeon
IPC: G01N21/03 , G01N1/42 , G01N1/44 , G01N21/17 , G01N21/25 , G01N21/35 , G01N21/3504 , G01N21/3577
Abstract: The present disclosure is directed toward a measurement system capable of rapid spectroscopic and calorimetric analysis of the chemical makeup of a test sample. Systems in accordance with the present disclosure include a low-thermal-mass sample holder having a substrate whose surface has been engineered to create a large-area sample-collection surface. The sample holder includes an integrated temperature controller that can rapidly heat or cool the test sample. As a result, the sample holder enables differential scanning calorimetry Fourier-Transform Infrared Spectroscopy (DSC-FTIR) that can be performed in minutes rather than hours, as required in the prior art.
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