公开(公告)号：NO20052757L

公开(公告)日：2005-06-07

申请号：NO20052757

申请日：2005-06-07

Applicant: SERVIER LAB

Inventor： BENNEJEAN CAROLINE ,  RENARD PIERRE ,  YOUS SAID ,  DELAGRANGE PHILIPPE ,  POISSONNIER-DURIEUX SOPHIE ,  BENNEJEAN DANIEL

IPC: A61P1/00 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/10 ,  A61P15/18 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02 ,  C07C233/18 ,  C07C233/36 ,  C07C233/60 ,  C07D207/26 ,  C07D207/27 ,  A61K31/16 ,  A61K31/40

Abstract: 1-(Amido-, ureido- or carbamoyl-alkyl)-3-(substituted methyl-phenyl)-naphthalene derivatives (I) are new. Phenyl-naphthalene derivatives of formula (I) and their enantiomers, diastereomers and acid or base addition salts are new. A = -NR2-CO-R1, -NR2-CO-NR1R'1 or -CO-NR1R'1; R1, R'1 = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-8C cycloalkyl, (3-8C) cycloalkyl-(1-6C) alkyl, aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; R2 = H or alkyl; or R1 + R2 = 3-6C linear or branched alkylene; R3 = 1-6C alkoxy; R4 = halo, OH, 1-6C alkoxy, NH2 or mono- or di-(1-6C alkyl)-amino; aryl moieties = phenyl, naphthyl or biphenylyl (all optionally substituted by 1-3 of 1-6C alkyl, 1-6C alkoxy, OH, COOH, CHO, NO2, CN, 1-6C polyhaloalkyl, alkoxycarbonyl or halo); p = 1-3; heteroaryl moieties = mono- or bicyclic aromatic group containing 1-3 of O, S and N as heteroatom(s) (optionally substituted as for aryl). Independent claims are included for: (a) the preparation of (I); and (b) new alkoxycarbonylphenyl-naphthalene derivative intermediates of formula (V) and their enantiomers, diastereomers and acid or base addition salts. R'5 = (1-6C) alkoxycarbonyl.

公开(公告)号：AU780027B2

公开(公告)日：2005-02-24

申请号：AU2746902

申请日：2002-03-19

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  C07D209/56 ,  A61K31/404 ,  A61P25/00

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.

公开(公告)号：NZ524330A

公开(公告)日：2004-12-24

申请号：NZ52433001

申请日：2001-07-16

Applicant: SERVIER LAB

Inventor： DESCAMPS-FRANCOIS CAROLE ,  YOUS SAID ,  LESIEUR DANIEL ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  DA COSTA HERVE ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: C07D333/58 ,  A61K31/235 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/437 ,  A61P3/04 ,  A61P3/10 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/20 ,  A61P25/28 ,  A61P35/00 ,  C07C231/12 ,  C07C233/18 ,  C07C233/60 ,  C07D209/08 ,  C07D209/20 ,  C07D307/68 ,  C07D307/79 ,  C07D307/81 ,  C07D333/54 ,  C07D471/04 ,  C07C209/16 ,  A61K31/165 ,  A61K31/335 ,  A61K31/38 ,  A61K31/40

Abstract: The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR' group, or a (C 1 -C 6 )alkyl group substituted by a COOR, CONRR' or OR group, G 1 represents a -X'-(CH 2 ) n -X-(CH 2 ) m -X''- chain wherein X, X', X'', n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G 2 represents an alkylene chain as defined in the description, and A represents a NRCOR', NRCSR', CONRR', CSNRR', NRCONR'R'' or NRCSNR'R'' group.

公开(公告)号：MA27070A1

公开(公告)日：2004-12-20

申请号：MA27596

申请日：2004-03-26

Applicant: SERVIER LAB

Inventor： POISSONNIER-DURIEUX SOPHIE ,  WALLEZ VALERIE ,  GASNEREAU ANNE ,  YOUS SAID ,  LESIEUR DANIEL ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  BENNEJEAN CAROLINE ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE

IPC: C07D217/14 ,  A61K31/472 ,  A61P1/00 ,  A61P3/02 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/02 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D217/16 ,  C07D217/24

Abstract: Nouveaux dérivés d'isoquinoleine, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

公开(公告)号：PL360574A1

公开(公告)日：2004-09-06

申请号：PL36057401

申请日：2001-07-16

Applicant: SERVIER LAB

Inventor： DESCAMPS-FRANCOIS CAROLE ,  YOUS SAID ,  LESIEUR DANIEL ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  DA COSTA HERVE ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: C07D333/58 ,  A61K31/235 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/437 ,  A61P3/04 ,  A61P3/10 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/20 ,  A61P25/28 ,  A61P35/00 ,  C07C231/12 ,  C07C233/18 ,  C07C233/60 ,  C07D209/08 ,  C07D209/20 ,  C07D307/68 ,  C07D307/79 ,  C07D307/81 ,  C07D333/54 ,  C07D471/04 ,  C07C209/16 ,  A61K31/165 ,  A61K31/335

Abstract: The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR' group, or a (C 1 -C 6 )alkyl group substituted by a COOR, CONRR' or OR group, G 1 represents a -X'-(CH 2 ) n -X-(CH 2 ) m -X''- chain wherein X, X', X'', n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G 2 represents an alkylene chain as defined in the description, and A represents a NRCOR', NRCSR', CONRR', CSNRR', NRCONR'R'' or NRCSNR'R'' group.

公开(公告)号：HU223468B1

公开(公告)日：2004-07-28

申请号：HU9800964

申请日：1998-04-24

Applicant: SERVIER LAB

Inventor： CHARTON ISABELLE ,  DELAGRANGE PHILIPPE ,  GUARDIOLA BEATRICE ,  GUILLAUMET GERALD ,  MAMAI AHMED ,  PFEIFFER BRUNO ,  RENARD PIERRE

IPC: A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/357 ,  A61K31/38 ,  A61K31/382 ,  A61P3/04 ,  A61P3/08 ,  A61P25/00 ,  A61P25/04 ,  A61P25/18 ,  A61P25/20 ,  A61P25/28 ,  A61P43/00 ,  C07D311/04 ,  C07D311/64 ,  C07D319/18 ,  C07D327/06 ,  C07D335/06

公开(公告)号：EA004711B1

公开(公告)日：2004-06-24

申请号：EA200200263

申请日：2002-03-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSARD ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94 ,  A61P25/00

Abstract: Изобретениерассматриваетсоединениеформулы (I)где R означаетатомводородаилигруппу, выбраннуюизалкенилаи необязательнозамещенногоалкила, каждыйиз R-R, которыемогутбытьодинаковымиилиразличными, означаетатомводородаилиалкил, алкенил, гидроксильнуюгруппу, алкоксигруппу, алкенилоксигруппу, арилалкил, арилалкоксигруппу, карбоксильнуюгруппу, ацилоксигруппуилиарилкарбонилоксигруппу, илиоднаизгрупп R-Rобразуетвместес расположеннойрядомоднойизгрупп R-Rалкилендиоксигруппу, егооптическиеизомеры, еслионисуществуют, иегоаддитивныесолис фармацевтическиприемлемымикислотойилиоснованием, приусловии, чтоесли R неозначаетатомводорода, тотогдакакминимумоднаизгрупп R-Rозначаетгидроксильнуюгруппуилиацилоксигруппу, исоединенияформулы (I) являютсяиными, кромеиндено[1,2-b]индол-10(5H)-она. Лекарственныесредства.

公开(公告)号：ES2207629T3

公开(公告)日：2004-06-01

申请号：ES02290668

申请日：2002-03-18

Applicant: SERVIER LAB

Inventor： WIERZBICKI MICHEL ,  BOUSSARD MARIE-FRANCOISE ,  ROUSSEAU ANNE ,  BOUTIN JEAN-ALBERT ,  DELAGRANGE PHILIPPE

IPC: C07D491/056 ,  A61K31/40 ,  A61K31/403 ,  A61K31/407 ,  A61K31/5377 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07D209/80 ,  C07D209/94

Abstract: Compound of formula (I):wherein:R represents hydrogen or a group selected from alkenyl and optionally substituted alkyl,each of R1 to R8, which may be identical or different, represents hydrogen or a group selected from alkyl, alkenyl, hydroxy, alkoxy, alkenyloxy, arylalkyl, arylalkoxy, carboxy, acyloxy and arylcarbonyloxy,or one of R1 to R8 forms with an adjacent one R1 to R8 an alkylenedioxy group,its optical isomers when they exist, and addition salts thereof with a pharmaceutically acceptable acid or base,with the proviso that:when R does not represent hydrogen, then at least one of R1 to R8 represents hydroxy or acyloxy,and the compounds of formula (I) are other than indeno[1,2-b]indol-10(5H)-one and medicinal products containing the same which are useful for treatment of disorders of the melatoninergic system.

公开(公告)号：DE60003103T2

公开(公告)日：2004-05-19

申请号：DE60003103

申请日：2000-03-24

Applicant: SERVIER LAB

Inventor： LESIEUR DANIEL ,  YOUS SAID ,  DESCAMPS-FRANCOIS CAROLE ,  LEFOULON FRANCOIS ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: C07D339/08 ,  A61K31/16 ,  A61K31/165 ,  A61K31/33 ,  A61K31/341 ,  A61K31/343 ,  A61K31/381 ,  A61K31/403 ,  A61K31/404 ,  A61K31/4045 ,  A61K31/437 ,  A61P3/04 ,  A61P3/10 ,  A61P5/00 ,  A61P9/00 ,  A61P15/18 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  B01J31/24 ,  C07B61/00 ,  C07C231/12 ,  C07C233/18 ,  C07C233/20 ,  C07C233/36 ,  C07C233/60 ,  C07C233/73 ,  C07C235/34 ,  C07C271/16 ,  C07C275/24 ,  C07C319/14 ,  C07C323/42 ,  C07D209/14 ,  C07D209/16 ,  C07D307/68 ,  C07D307/79 ,  C07D307/81 ,  C07D311/58 ,  C07D319/20 ,  C07D333/58 ,  C07D471/04 ,  C07D519/00

Abstract: Compounds (I) selected from alkylenedioxybisnaphthalene derivatives and related compounds are new. Compounds of formula (I) other than diethyl 2-acetylamino-2-(5-(3-(2-acetylamino-3-ethoxy-2-ethoxycarbonyl-3-oxopr opyl)-1H-indol-5-ylmethyl)-1H-indol-3-ylmethyl)malonate and N-(2-(5-(3-(2-acetylaminoethyl)-1H-indol-5-ylmethyl)-1H-indol-3-yl)eth yl)acetamide are new. A = NR -C(Q)-R , NR -C(Q)-NR R or C(Q)-NR R ; Q = O or S; R - R = H or R; or NR R = 1-piperazinyl, piperidino or pyrrolidino; R = optionally Q'-substituted 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 3-8C cycloalkyl or (3-8C cycloalkyl)-(1-6C alkyl); 1-6C polyhaloalkyl; or optionally Q-substituted aryl, aryl(1-6C alkyl), aryl(2-6C alkenyl), heteroaryl, heteroaryl-(1-6C alkyl) or heteroaryl-(2-6C alkenyl); B = NR -C(Q)-R , NR -C(Q)-NR R , C(Q)-NR R , C(Q)-OR , NR -C(Q)-OR or NR R ; G1, G3 = 1-4C alkylene optionally substituted by one or more of OH, COOH, CHO, R, OR, C(O)OR or C(O)R; Cy = a group of formula (i) in which G2 is attached to the benzene ring and G1 or G3 is attached to the other ring, or a group of formula (ii) in which G2 is attached to the D ring and G1 or G3 is attached to the other ring: X, Y' = S, O, C, CH or CH2; R = H, halogen, CF3, OH, COOH, CHO, NH2, NHR, NRR', NHC(O)R, C(O)NHR, R, OR, C(O)R or COOR; R' = R; Z' = S, O, CH, CH2, NH, NSO2-phenyl or NR; D' = a benzene or pyridine ring; G2 = an optionally substituted W1(CH2)nW2(CH2)mW3 group containing no adjacent heteroatoms; W1-W3 = bond, O, S, CH2, CHR, NH or NR; n, m = 0 - 6; Q' = one or more of OH, 1-6C alkoxy, 1-6C polyhaloalkyl, NH2, 1-6C alkylamino, di(1-6C alkyl)amino and halogen; aryl = naphthyl, phenyl or biphenylyl; heteroaryl = a saturated or unsaturated mono- or bicyclic group containing 5-10 C atoms and 1-3 heteroatoms selected from N, S and O; and Q = OH, COOH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CHO, CN, NO2, NH2, 1-6C alkylamino, di(1-6C alkyl)amino and halogen. Independent claims are also included for the following: (1) a process for preparing (I); and (2) compounds of formula (II) other than N-(2-(5-(2-hydroxyethoxy)-1H-indol-3-yl)ethyl)acetamide. W4 = O, S, NH or NR; and E' = OH or halogen; provided that W4-(CH2)n-W2-(CH2)m is not oxyalkylene when Cy is naphthylene and G1-A is (CH2)2-NR CQR or (CH2)2-NR CQNR R .

公开(公告)号：HK1058354A1

公开(公告)日：2004-05-14

申请号：HK04101072

申请日：2004-02-16

Applicant: SERVIER LAB

Inventor： DESCAMPS-FRANCOIS CAROLE ,  YOUS SAID ,  LESIEUR DANIEL ,  GUILLAUMET GERALD ,  VIAUD MARIE-CLAUDE ,  COSTA HERVE DA ,  BENNEJEAN CAROLINE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE

IPC: C07D333/58 ,  A61K31/235 ,  A61K31/343 ,  A61K31/381 ,  A61K31/4045 ,  A61K31/437 ,  A61P3/04 ,  A61P3/10 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/16 ,  A61P25/20 ,  A61P25/28 ,  A61P35/00 ,  C07C231/12 ,  C07C233/18 ,  C07C233/60 ,  C07D209/08 ,  C07D209/20 ,  C07D307/68 ,  C07D307/79 ,  C07D307/81 ,  C07D333/54 ,  C07D471/04 ,  C07C ,  C07D ,  A61K

Abstract: The invention relates to compounds of formula (I): wherein: B represents a hydrogen atom, a COOR group, a CONRR' group, or a (C 1 -C 6 )alkyl group substituted by a COOR, CONRR' or OR group, G 1 represents a -X'-(CH 2 ) n -X-(CH 2 ) m -X''- chain wherein X, X', X'', n and m are as defined in the description, Cy represents a grouping of formula (II) or (III): G 2 represents an alkylene chain as defined in the description, and A represents a NRCOR', NRCSR', CONRR', CSNRR', NRCONR'R'' or NRCSNR'R'' group.