公开(公告)号：AT512145T

公开(公告)日：2011-06-15

申请号：AT06801307

申请日：2006-08-11

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH ,  VAN GOOR FREDRICK ,  MILLER MARK ,  MCCARTNEY JASON ,  ARUMUGAM VIJAYALAKSMI ,  ZHOU JINGLAN

IPC: C07D417/14 ,  A61K31/427 ,  A61P25/16

Abstract: The present invention relates to modulators of cystic fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating CFTR mediated diseases using such modulators.

公开(公告)号：AU2010251789A1

公开(公告)日：2011-01-06

申请号：AU2010251789

申请日：2010-12-14

Applicant: VERTEX PHARMA

Inventor： RUAH SARAH S HADIDA ,  SINGH ASHVANI K ,  GROOTENHUIS PETER D J ,  HAZLEWOOD ANNA R ,  GOOR FREDRICK F VAN ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D401/12 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：AU2010249302A1

公开(公告)日：2011-01-06

申请号：AU2010249302

申请日：2010-12-13

Applicant: VERTEX PHARMA

Inventor： RUAH SARAH S HADIDA ,  SINGH ASHVANI K ,  GROOTENHUIS PETER D J ,  HAZLEWOOD ANNA R ,  GOOR FREDRICK F VAN ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D401/12 ,  A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/56 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：NZ552543A

公开(公告)日：2010-09-30

申请号：NZ55254305

申请日：2005-06-24

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: A61K31/47 ,  A61K31/4709 ,  A61P25/00 ,  A61P31/00 ,  C07C215/76 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/18 ,  C07D215/233 ,  C07D215/56 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

Abstract: Disclosed are 4-oxo-quinoline-3-carboxamide derivatives of general formula (I), wherein the substituents are as defined herein. Of particular importance is the compound N-(5-hydroxy-2,4-ditert-butyl-phenyl)-4-oxo-1H-quinoline-3-caboxamide, or a pharmaceutically acceptable salt thereof. Also disclosed is a pharmaceutical composition comprising a compound as defined above and a pharmaceutically acceptable carrier or adjuvant. Further disclosed is the use of a compound or composition as described above in the manufacture of a medicament for treating or lessening the severity of cystic fibrosis in a patient (wherein the patient may possess a cystic fibrosis transmembrane receptor (CFTR)).

公开(公告)号：CA2742980A1

公开(公告)日：2010-05-14

申请号：CA2742980

申请日：2009-11-06

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  MILLER MARK T ,  MCCARTNEY JASON ,  VAN GOOR FREDRICK ,  NUMA MEHDI MICHEL DJAMEL ,  ZHOU JINGLAN ,  BEAR BRIAN

IPC: C07D405/02 ,  A61K31/404 ,  A61P3/00 ,  A61P25/00 ,  C07D209/08 ,  C07D209/12 ,  C07D209/18

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：ZA200700601B

公开(公告)日：2008-11-26

申请号：ZA200700601

申请日：2007-01-22

Applicant: VERTEX PHARMA

Inventor： HADIDA RUAH SARAH S ,  HAZLEWOOD ANNA R ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDERICK F ,  SINGH ASHVANI K ,  ZHOU JINGLAN ,  MCCARTNEY JASON

IPC: C07D20090101

Abstract: The present invention relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, composition thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.

公开(公告)号：CA2686838A1

公开(公告)日：2008-11-20

申请号：CA2686838

申请日：2008-05-09

Applicant: VERTEX PHARMA

Inventor： MCCARTNEY JASON ,  BEAR BRIAN ,  ZHOU JINGLAN ,  MILLER MARK ,  HADIDA RUAH SARA ,  GROOTENHUIS PETER D J

IPC: C07D401/04 ,  A61K31/444 ,  A61P11/00 ,  A61P37/00 ,  C07D405/14

Abstract: Compounds of the present invention, and pharmaceutically acceptable compo sitions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") tr ansporters or fragments thereof, including Cystic Fibrosis Transmembrane Con ductance Regulator ("CFTR"). The present invention also relates to methods o f treating CFTR mediated diseases using compounds of the present invention.

公开(公告)号：CA2869945A1

公开(公告)日：2007-10-18

申请号：CA2869945

申请日：2007-04-09

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  GROOTENHUIS PETER D J ,  VAN GOOR FREDRICK ,  ZHOU JINGLAN ,  BEAR BRIAN ,  MILLER MARK T ,  MCCARTNEY JASON ,  NUMA MEHDI MICHEL JAMEL ,  YANG XIAOQING

IPC: C07D405/12 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4439 ,  A61K31/454 ,  C07D209/08 ,  C07D403/12 ,  C07D413/12 ,  G01N33/48

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ('ABC') transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ('CFTR'). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：AU2007235260A1

公开(公告)日：2007-10-18

申请号：AU2007235260

申请日：2007-04-09

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  MCCARTNEY JASON ,  ZHOU JINGLAN ,  GOOR FREDERICK VAN ,  MILLER MARK T ,  NUMA MEHDI MICHEL JAMEL ,  BEAR BRIAN ,  GROOTENHUIS PETER D J

IPC: C07D405/12 ,  A61K31/404 ,  A61P31/00 ,  C07D405/14

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

公开(公告)号：CA2856037A1

公开(公告)日：2007-08-02

申请号：CA2856037

申请日：2006-12-28

Applicant: VERTEX PHARMA

Inventor： RUAH SARA S HADIDA ,  MILLER MARK T ,  BEAR BRIAN ,  MCCARTNEY JASON ,  GROOTENHUIS PETER D J

IPC: C07C237/24 ,  A61K31/00 ,  C07C311/46 ,  C07D207/12 ,  C07D307/79 ,  C07D317/60 ,  C07D319/18 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D498/04

Abstract: Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP -Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.