Vブロック方式の屈折率測定装置
    111.
    发明申请
    Vブロック方式の屈折率測定装置 审中-公开
    V型压力计

    公开(公告)号:WO2015001649A1

    公开(公告)日:2015-01-08

    申请号:PCT/JP2013/068410

    申请日:2013-07-04

    Abstract:  測定精度を向上することができるVブロック方式の屈折率測定装置を提供する。コリメータレンズ48からVブロックプリズム1に入射する測定光の入射角度をモータ7の回転により変化させ、各入射角度におけるVブロックプリズム1からの測定光を検出器2で検出する。これにより、従来のようにモータ7の近傍に検出器2を配置する必要がなくなるため、モータ7にかかる負荷の増加などに起因して測定精度が悪くなるのを防止し、測定精度を向上することができる。

    Abstract translation: 提供了能够提高测量精度的V型块折射计。 来自准直透镜(48)并且入射在V形棱镜(1)上的测量光的入射角通过马达(7)的旋转而改变,并且在每个入射角处,测量光 由检测器(2)检测来自V型块棱镜(1)的位置。 结果,如以往的折光计那样,不需要将检测器(2)配置在电动机(7)附近,因此能够防止在电动机(7)上由负载增加引起的测量精度的劣化等, 可以提高测量精度。

    ANALYTICAL DEVICES HAVING COMPACT LENS TRAIN ARRAYS
    112.
    发明申请
    ANALYTICAL DEVICES HAVING COMPACT LENS TRAIN ARRAYS 审中-公开
    具有紧凑型镜头火腿阵列的分析装置

    公开(公告)号:WO2014194028A1

    公开(公告)日:2014-12-04

    申请号:PCT/US2014/039917

    申请日:2014-05-29

    Abstract: Apparatus, systems and methods for use in analyzing discrete reactions are provided. The analytical devices of the invention use an array of nanoscale regions (a chip) that has discrete patches of nanoscale regions. The chip mates with a collection device comprising an array of compact lens trains (CLTs) where each of the CLTs corresponds to a single patch of nanoscale regions. Each CLT collects the emitted light from a patch on the chip, collimates the light, performs color separation on the collimated emitted light, and focuses the separated light onto a portion of pixels on the detector below the CLT. Such systems are useful for monitoring many analytical reactions at one time including single molecule sequencing reactions.

    Abstract translation: 提供了用于分析离散反应的装置,系统和方法。 本发明的分析装置使用具有分散的纳米尺度区域的纳米尺度区域(芯片)阵列。 该芯片与包括紧凑型透镜列阵列(CLT)的收集装置配合,其中每个CLT对应于单个纳米尺度区域。 每个CLT收集来自芯片上的贴片的发射光,准直光,在准直发射的光上进行颜色分离,并将分离的光聚焦到CLT下方的检测器上的像素部分上。 这样的系统可用于一次监测许多分析反应,包括单分子测序反应。

    A KIT FOR DETECTING MICRO-RNA EXTRACTED FROM A SAMLPLE OF BODY FLUID AS WELL AND A METHOD FOR THE DETECTION THEREOF
    113.
    发明申请
    A KIT FOR DETECTING MICRO-RNA EXTRACTED FROM A SAMLPLE OF BODY FLUID AS WELL AND A METHOD FOR THE DETECTION THEREOF 审中-公开
    用于检测从身体液体提取的微RNA的试剂盒及其检测方法

    公开(公告)号:WO2014191850A1

    公开(公告)日:2014-12-04

    申请号:PCT/IB2014/060793

    申请日:2014-04-17

    Abstract: It's disclosed a kit for detecting a micro-RNA of interest in at least one sample (C) extracted from a body fluid, comprising: at least one device (2) including a housing casing (2a) in which at least one housing seat (2b) is obtained for said at least one sample (C), and at least one opening (2c) through which said housing seat (2b) is accessible from the outside; at least one container means (3) for said at least one sample (C), said at least one container means (3) being insertable/disconnectable in/from said housing seat (2b) through said at least one opening (2c); at least one optical excitation group (5), housed in said housing casing (2a), designed to emit at least one excitation light radiation (λ, λ1 ) towards said at least one housing seat (2b); at least one detection group (6), designed to detect at least one emission light radiation (λ2), that can be generated, in use, by said at least one sample (C), said at least one sample (C) being optically excitable by said at least one excitation light radiation (λ, λ1) emitted by said at least one optical excitation group (5), said at least one detection group (6) being designed to supply at least one electric output signal (SO- signal output) correlated with the quantity, in said at least one sample (C), of said micro-RNA of interest; at least one processing unit (7) designed to receive and process said at least one electric signal (SO) and to output an index correlated with the quantity of said micro-RNA of interest in said at least one sample (C); said at least one container means (3) being made of a material permeable to said at least one excitation light radiation (λ, λ1) and to said at least one emission light radiation (A2); said at least one group (6) for detecting said emission light radiation (A2) comprises at least one sensor means (6a) of silicon photomultiplier type.

    Abstract translation: 公开了用于检测从体液中提取的至少一个样品(C)中感兴趣的微RNA的试剂盒,其包括:至少一个装置(2),其包括壳体壳体(2a),其中至少一个壳体座 获得所述至少一个样品(C)的至少一个开口(2c),以及至少一个开口(2c),所述壳体座(2b)可以从外部进入; 用于所述至少一个样品(C)的至少一个容器装置(3),所述至少一个容器装置(3)可通过所述至少一个开口(2c)从所述壳体座(2b)插入/断开; 容纳在所述壳体壳体(2a)中的至少一个光学激发组(5)被设计成朝向所述至少一个壳体座(2b)发射至少一个激发光辐射(λ,λ1); 至少一个检测组(6),被设计成检测在所述至少一个样品(C)中可以在使用中产生的至少一个发射光辐射(λ2),所述至少一个样品(C)是光学的 由所述至少一个光学激发组(5)发射的所述至少一个激发光辐射(λ,λ1)激发,所述至少一个检测组(6)被设计成提供至少一个电输出信号(SO-信号 输出)与所述至少一个样品(C)中所述感兴趣的微RNA的量相关; 至少一个处理单元(7)被设计为接收和处理所述至少一个电信号(SO)并输出与所述至少一个样品(C)中的所述感兴趣的微RNA的量相关的指数; 所述至少一个容器装置(3)由可透过所述至少一个激发光辐射(λ,λ1)和所述至少一个发射光辐射(A2)的材料制成; 所述至少一个用于检测所述发射光辐射的组(6)包括至少一个硅光电倍增器类型的传感器装置(6a)。

    HANDHELD LIBS SPECTROMETER
    114.
    发明申请
    HANDHELD LIBS SPECTROMETER 审中-公开
    手持式射线光谱仪

    公开(公告)号:WO2014113824A2

    公开(公告)日:2014-07-24

    申请号:PCT/US2014016188

    申请日:2014-02-13

    Applicant: SCIAPS INC

    Abstract: A handheld LIBS spectrometer includes an optics stage movably mounted to a housing and including a laser focusing lens and a detection lens. One or more motors advance and retract the optics stage, move the optics stage left and right, and/or move the optics stage up and down. A laser source in the housing is oriented to direct a laser beam to the laser focusing lens. A spectrometer subsystem in the housing is configured to receive electromagnetic radiation from the detection lens and to provide an output. A controller subsystem is responsive to the output of the spectrometer subsystem and is configured to control the laser source and motors. In this way, auto-calibration, auto-clean, and auto-focus, and/or moving spot functionality is possible.

    Abstract translation: 手持式LIBS光谱仪包括可移动地安装到壳体并包括激光聚焦透镜和检测透镜的光学台。 一个或多个电机推进和缩回光学平台,左右移动光学台,和/或上下移动光学平台。 壳体中的激光源被定向成将激光束引导到激光聚焦透镜。 外壳中的光谱仪子系统被配置为从检测透镜接收电磁辐射并提供输出。 控制器子系统响应于光谱仪子系统的输出,并被配置为控制激光源和电动机。 这样就可以进行自动校准,自动清理和自动对焦,和/或移动点功能。

    LIGHTING SYSTEMS AND METHODS OF USING LIGHTING SYSTEMS FOR IN VITRO POTENCY ASSAY FOR PHOTOFRIN
    115.
    发明申请
    LIGHTING SYSTEMS AND METHODS OF USING LIGHTING SYSTEMS FOR IN VITRO POTENCY ASSAY FOR PHOTOFRIN 审中-公开
    照明系统和使用照明系统进行光敏素体外效能测定的方法

    公开(公告)号:WO2014081450A2

    公开(公告)日:2014-05-30

    申请号:PCT/US2013020485

    申请日:2013-01-07

    Abstract: Presently disclosed is a lighting system and methods of using the lighting system for in vitro potency assay for photofrin. The lighting system includes a lamp housing, a first lens, an infrared absorbing filter, an optical filter, and a second lens. The lamp housing includes a lamp and a light-port. In operation, broad spectrum light from the lamp exits the lamp housing by passing through the light-port. The first lens then collimates the broad spectrum light that exits the lamp housing through the light-port. The infrared absorbing filter then passes a first portion of the collimated broad spectrum light to the optical filter and absorbs infrared light of the broad spectrum light. The optical filter then passes a second portion of the collimated broad spectrum light to the second lens. The second lens then disperses the second portion of the collimated light to provide uniform irradiation of a cell culture plate. A method of using the lighting system for studying a photosensitizer is also disclosed.

    Abstract translation: 目前公开的是照明系统和使用该照明系统用于光敏素的体外效力测定的方法。 照明系统包括灯壳,第一透镜,红外吸收滤光器,滤光器和第二透镜。 灯壳包括一个灯和一个灯口。 在操作中,来自灯的广谱光线通过灯端口离开灯壳。 然后第一个透镜将通过光端口离开灯壳的广谱光线准直。 红外吸收滤光片然后将准直的宽谱光的第一部分传递到滤光器并吸收广谱光的红外光。 然后光学滤波器将准直的宽光谱光的第二部分传递到第二透镜。 第二透镜然后分散准直光的第二部分以提供细胞培养板的均匀照射。 还公开了使用照明系统来研究光敏剂的方法。

    SYSTEM AND METHOD FOR QUANTITATIVE OR QUALITATIVE MEASUREMENT OF EXOGENOUS SUBSTANCES IN TISSUE AND OTHER MATERIALS USING LASER-INDUCED FLUORESCENCE SPECTROSCOPY
    117.
    发明申请
    SYSTEM AND METHOD FOR QUANTITATIVE OR QUALITATIVE MEASUREMENT OF EXOGENOUS SUBSTANCES IN TISSUE AND OTHER MATERIALS USING LASER-INDUCED FLUORESCENCE SPECTROSCOPY 审中-公开
    使用激光诱导荧光光谱对组织和其他材料中的异体物质进行定量或定性测量的系统和方法

    公开(公告)号:WO03085376A2

    公开(公告)日:2003-10-16

    申请号:PCT/US0310490

    申请日:2003-04-03

    Abstract: Methods and systems for the quantitative and qualitative determination of one or more exogenous substances within a material are described. A flow of fluorescence-exciting/ablative energy (e.g., laser pulse(s), preferably in the ultraviolet region (e.g. 193-nm)), is directed onto the material to ablate a thin layer (e.g. ≈ 0.3-µm) of the material using photochemical decomposition. Simultaneously, the laser energy induces the fluorescence of the substance(s) of interest within the ablated layer of the material. The fluorescence emitted by the substance(s) of interest is then received by a device (e.g., a spectrometer), which measures the spectrum (i.e. intensity versus wavelength) of the received fluorescence. The fluorescence spectra are then transmitted to a spectral processing device (e.g., a microprocessor or computer) which is programmed or otherwise adapted to determine, on the basis of the fluoroscence spectra, whether the substance(s) of interest is/are present in the material and/or the concentration at which the substance(s) of interest is/are present in the material. This process may be repeated for each layer of the material to determine the concentration gradient of the substance(s) of interest in the material.

    Abstract translation: 描述了用于定量和定性测定材料内的一种或多种外源物质的方法和系统。 荧光激发/消融能量(例如,优选在紫外区域(例如193nm)的激光脉冲))的流动被引导到材料上以消融所述材料的薄层(例如≈0.3μm) 材料使用光化学分解。 同时,激光能量在材料的烧蚀层内感应感兴趣的物质的荧光。 由感兴趣的物质发射的荧光然后由测量接收的荧光的光谱(即强度对波长)的装置(例如,光谱仪)接收。 然后将荧光光谱传输到频谱处理装置(例如,微处理器或计算机),该处理装置被编程或以其他方式适于基于荧光光谱确定目的物质是否存在于 材料和/或感兴趣物质存在于材料中的浓度。 可以针对材料的每层重复该过程以确定材料中感兴趣的物质的浓度梯度。

    TEST DEVICE, TEST SYSTEM, AND CONTROL METHOD OF THE TEST DEVICE
    118.
    发明公开
    TEST DEVICE, TEST SYSTEM, AND CONTROL METHOD OF THE TEST DEVICE 审中-公开
    测试装置,测试系统和测试装置的控制方法

    公开(公告)号:EP3315942A1

    公开(公告)日:2018-05-02

    申请号:EP17193182.7

    申请日:2017-09-26

    Abstract: A test device (100), test system, and control method of the test device (100), which defines a light irradiating area in a reactor (20) to prevent a decrease in magnitude of a detected signal that may result due to scattering of light that has penetrated other area of the reactor (20) than an area (25) containing an object for detection and improve a dynamic range. A test device (100) may include a light source (130) configured to irradiate light; a reactor (20) configured to include at least one first area (25) to contain an object for detection; and a photo detector (150) configured to receive light that has been irradiated from the light source (130) and has passed the reactor (20) that contains the object for detection, wherein the light source (130) is configured to limitedly irradiate the light to the first area (25) of the reactor (20).

    Abstract translation: 测试装置(100)的测试装置(100),测试系统和控制方法限定反应器(20)中的光照射区域以防止可能由于散射导致的检测信号的幅度的减小 已经穿过反应器(20)的其他区域的光而不是包含用于检测的对象的区域(25)并且改善动态范围。 测试装置(100)可以包括被配置为照射光的光源(130) 反应器(20),配置为包括至少一个第一区域(25)以容纳用于检测的物体; 和光检测器(150),被配置为接收已经从所述光源(130)照射并且已经经过包含所述检测对象的所述反应器(20)的光,其中所述光源(130)被配置为有限地照射 光照射到反应器(20)的第一区域(25)。

    VERFAHREN UND VORRICHTUNG ZUR ANALYSE VON ALKOHOLISCHEN GETRÄNKEN
    119.
    发明公开
    VERFAHREN UND VORRICHTUNG ZUR ANALYSE VON ALKOHOLISCHEN GETRÄNKEN 审中-公开
    用于分析酒精饮料的方法和装置

    公开(公告)号:EP3306304A1

    公开(公告)日:2018-04-11

    申请号:EP17191538.2

    申请日:2017-09-18

    Inventor: Rosenfeld, Klaus

    Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Analyse von alkoholischen Getränken mittels eines Raman-Spektrometers (10) zur Detektion eines Raman-Spektrums einer zu untersuchenden Probe (20) mit mindestens einer optischen Einrichtung zur Erzeugung eines Laserstrahls, mindestens einem motorisierten Filter unterschiedlicher optischer Dichte zur Einstellung der Laserintensität auf der Probe und mindestens einer Linse für Licht im sichtbaren Spektrum, wobei zur Messung der Streuung, Absorption, Transmission und/oder Reflexion Transmissions- und Reflexionsmessung ferner ein Mikroskop (11) mit einer Halterung (12) für das zu untersuchende Probe (20) vorgesehen ist. Dem Verfahren liegt die Aufgabe zugrunde, ein alkoholisches Getränk innerhalb eines geschlossenen Behältnisses zu analysieren. Erfindungsgemäß wird diese Aufgabe dadurch gelöst, dass die Messung innerhalb eines unterhalb des Objektivs (110) des Mikroskops (11) an der Halterung (12) anordbaren, flaschenartigen Behältnisses (2) vorgenommen wird, wobei der einfallende Laserstrahl mit einem Macro-Objektiv (110) auf den interessierenden Probenbereich (20) innerhalb des flaschenartigen Behältnisses (2) fokussiert wird.

    Abstract translation: 本发明通过拉曼光谱仪(10),用于检测待检查样品(20)与至少一个光学装置的拉曼光谱用于产生激光束,至少不同的光密度的机动化过滤器的装置涉及一种用于酒精饮料的分析的方法 在样品上的激光强度,并在可见光谱中的至少一个透镜的光的调整,用于测量散射,吸收,透射和/或反射透射和反射测量进一步包括具有用于所述材料的支架(12)的显微镜(11),以待检查样品 (20)。 该方法的目的是分析封闭容器内的酒精饮料。 根据该目的的实现在于内的显微镜(11)连接到托架(12)的所述透镜(110)下方的测量可以布置本发明,瓶状容器(2)制成,其中与宏透镜入射激光束(110 )集中在瓶状容器(2)内的感兴趣样本区域(20)上。

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