Abstract:
An optical probe for non-invasively measuring an analyte property in a biological sample of a subject, comprises a plurality of illumination fibers that deliver source light from an optical probe input to a sample interface, a plurality of collection fibers that deliver light returned from the sample interface to an optical probe output, and wherein the illumination and collection fibers are oriented substantially perpendicular to the sample interface and the illumination and collection fibers are stacked in a plurality of linear rows to provide a stack of fibers arranged in a rectangular pattern. The optical probe is amenable to manufacturing on a scale consistent with a commercial product.
Abstract:
The disclosure relates to a portable system having a fiber array spectral translator (“FAST”) for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
Abstract:
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
Abstract:
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
Abstract:
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
Abstract:
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
Abstract:
Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light source. A first optical fiber is coupled to the light source and illuminates the biosensor. A second optical fiber detects a wavelength reflected from the biosensor. A spectrometer determines spectra of a reflected signal from the biosensor.
Abstract:
The spectrum of light, inelastically scattered by a sample (16) is measured. The light is guided through a capillary (12) from and to the sample, at least in one of these directions, through the channel no inelastic scattering of light occurs which can form an interfering background when measuring on the sample. By guiding the light through the channel, inelastic scattering of this light is prevented and it becomes possible to guide scattered light back through the channel to spectral analysis equipment (14) without problems with inelastic scattering during the guidance of the light. Preferably, the light is guided through the channel of the capillary in both directions.
Abstract:
A molecular sieve particle-based analytic chemistry system is disclosed in which populations of encoded molecular sieve particles carrying different chemical functionalities are distributed into wells etched in an optical fiber bundle. The chemical functionalities are encoded on separate shaped molecular sieve particles using luminescent dyes and/or molecular sieve particle shapes and thus, a single sensor array may carry thousands of chemistries. Such encoded molecular sieve particles can provide at least a five-fold enhancement in tunable parameters for increasing the encoding possibilities of high throughput screening assays relative to the present dye-modified polymeric microsphere standard.
Abstract:
The translucency of a material is determined by illuminating the material and detecting the intensity of radiation leaving the material as a function of distance from the radiation source. The resulting measurements may be used to determine a "translucency gradient" for the material. In the case of materials in sheet form or having a defined thickness, the translucency can be measured in transmission mode or back scattering mode to measure "through translucency" or "surface translucency".