公开(公告)号：AU2014201215A1

公开(公告)日：2014-04-03

申请号：AU2014201215

申请日：2014-03-05

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  YU ALICE ,  YU JOHN

IPC: A61K39/00 ,  A61K39/385

Abstract: The present invention provides for an immunogenic composition comprising (a) a glycan, such as Globo H, stage-specific embryonic antigen-3 (SSEA-3) or SSEA-4, conjugated to a carrier protein through a linker; (b) an adjuvant comprising a glycolipid, such as a-galactosyl-ceramide adjuvant, wherein the composition induces an immune response, such as a higher relative level of IgG isotype antibodies compared to IgM isotype antibodies, or neutralising antibodies against at least one antigen selected from the group consisting of Globo H, Gb4, SSEA-3, and SSEA-4. Uses of the immunogenic composition for treating or inhibiting tumour growth are also provided.

公开(公告)号：AU2008292859C1

公开(公告)日：2014-03-06

申请号：AU2008292859

申请日：2008-08-29

Applicant: ACADEMIA SINICA

Inventor： CHENG YIH-SHYUN EDMOND ,  FANG JIM-MIN ,  JAN JIA-TSRONG ,  WONG CHI-HUEY ,  SHIE JIUN-JIE

IPC: C07F9/00 ,  A61K9/16 ,  A61K31/7052 ,  A61K31/7076 ,  C07C233/52 ,  C07C247/14 ,  C07H19/04

Abstract: Novel phosphonate compounds are described. The compounds have activity as neuraminidase inhibitors against wild-type and H274Y mutant of H1N1 and H5N1 viruses. The present disclosure also provides an enantioselective synthetic route to known neuraminidase inhibitors oseltamivir and the anti-flu drug Tamiflu®, as well as novel phosphonate compounds, via D-xylose. Another efficient and flexible synthesis of Tamiflu and the highly potent neuraminidase inhibitor Tamiphosphor was also achieved in 11 steps and > 20% overall yields from the readily available fermentation product (1

公开(公告)号：CA3129035A1

公开(公告)日：2014-02-27

申请号：CA3129035

申请日：2013-08-20

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

Abstract: A novel UDP-Gal regeneration process and its combined use with a galactosyltransferase to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

公开(公告)号：CA3052909A1

公开(公告)日：2014-02-27

申请号：CA3052909

申请日：2013-08-20

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  TSAI TSUNG-I

IPC: C12P19/18 ,  C12M1/40 ,  C12N9/10 ,  C12N9/12 ,  C12P19/00 ,  C12P19/04 ,  C12P19/30

Abstract: A novel UDP-Gal regeneration process and its combined use with a galactosyltransferase to add galactose to a suitable acceptor substrate. Also described herein are synthetic methods for generating Globo-series oligosaccharides in large scale, wherein the methods may involve the combination of a glycosyltransferase reaction and a nucleotide sugar regeneration process.

公开(公告)号：CA2883168A1

公开(公告)日：2014-02-27

申请号：CA2883168

申请日：2013-08-21

Applicant: ACADEMIA SINICA ,  WONG CHI-HUEY ,  FANG JIM-MIN ,  SHIE JIUN-JIE

Inventor： WONG CHI-HUEY ,  FANG JIM-MIN ,  SHIE JIUN-JIE

IPC: C07D311/06 ,  A61K31/37 ,  A61P29/00 ,  C07D491/04 ,  C07D493/04

Abstract: Provided are benzocyclooctyne compounds of formula (I). These compounds undergo strain-promoted azide-alkyne cyclo additions (SPAAC) without presence of toxic metal catalysts. The provided compounds are useful for diagnosis and imaging of azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.

公开(公告)号：AU2009269127B2

公开(公告)日：2013-12-05

申请号：AU2009269127

申请日：2009-08-06

Applicant: ACADEMIA SINICA

Inventor： YU ALICE ,  WONG CHI-HUEY ,  YU JOHN ,  WU CHUNG-YI

IPC: A61K39/00 ,  A61K39/385

Abstract: Immunogenic compositions, cancer vaccines and methods for treating cancer are provided. Compositions comprising: (a) a glycan such as Globo H or an immunogenic fragment thereof, wherein the glycan is conjugated with a carrier protein by a linker such as para-nitrophenyl; and (b) an adjuvant comprising glycolipid capable of binding CDId on a dendritic cell, such as an α-galactosyl-ceramide derivative, wherein the immunogenic composition induces an immune response that induces a higher relative level of IgG isotype antibodies as compared to IgM isotype antibodies, are provided. Immunogenic compositions comprising the carrier protein diphtheria toxin cross-reacting material 197 (DT-CRM 197) and the adjuvant C34 are provided. Antibodies generated by immunogenic compositions disclosed herein further neutralize at least one of the antigens Globo H, stage-specific embryonic antigen-3 (SSEA-3) and stage-specific embryonic antigen-4 (SSEA-4). Therapeutics against breast cancer stem cells comprising immunogenic compositions comprising Globo H, SSEA-3 or SSEA-4 conjugated with DT-CRM 197.

公开(公告)号：GB2461656B

公开(公告)日：2012-11-21

申请号：GB0917142

申请日：2009-07-10

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  YU ALICE ,  CHANG YA-JEN ,  LIN KUN-HSIEN ,  CHENG Y S EDMOND ,  JAN JIA-TSRONG ,  LIN YI-LING ,  HUNG JUNG-TUNG

IPC: C07H15/18 ,  A61K31/7034 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P43/00

公开(公告)号：MX2010013931A

公开(公告)日：2011-06-01

申请号：MX2010013931

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

IPC: G01N33/574 ,  G01N33/53

Abstract: Un método de diagnóstico de cáncer que usa un arreglo de glucano que contiene Gb5 y Globo H, Bb2, Bb3 y/o Bb4.

公开(公告)号：CA2728574A1

公开(公告)日：2010-01-21

申请号：CA2728574

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： WONG CHI-HUEY ,  WU CHUNG-YI ,  WANG CHENG-CHI ,  YU ALICE L

IPC: G01N33/574 ,  G01N33/53

Abstract: A cancer diagnostic method using a glycan array that contains Gb5 and Globo H, Bb2, Bb3, and/or Bb4.

公开(公告)号：CA2728344A1

公开(公告)日：2010-01-14

申请号：CA2728344

申请日：2009-06-16

Applicant: ACADEMIA SINICA

Inventor： YU ALICE L ,  YU JOHN ,  WONG CHI-HUEY

IPC: A61K31/716 ,  A61K31/164 ,  A61K31/7008 ,  A61P35/00

Abstract: An immune composition containing Globo H or its fragment (e.g., SSEA3) and an adjuvant, e.g., a -GalCer, for eliciting immune responses against Globo H or its fragment and uses thereof in cancer treatment. Also disclosed is a method of treating cancer by inhibiting the activity of one of FUT1 and FUT2, both of which involve in Globo H biosynthesis.