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公开(公告)号：NO984714A
公开(公告)日：1998-10-09
申请号：NO984714
申请日：1998-10-09
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , HILLEN HEINZ , UNGER LILIANE , ELGER BERND
IPC: C07D251/30 , A61K31/00 , A61K31/505 , A61K31/517 , A61K31/529 , A61K31/53 , A61P7/00 , A61P9/00 , A61P9/02 , A61P9/12 , A61P13/00 , A61P13/08 , A61P13/12 , C07D239/34 , C07D239/46 , C07D239/52 , C07D239/60 , C07D239/70 , C07D251/48 , C07D403/12 , C07D491/044
CPC classification number: C07D239/46
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公开(公告)号：MX9801987A
公开(公告)日：1998-08-30
申请号：MX9801987
申请日：1998-03-13
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED
IPC: A61K31/00 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/444 , A61K31/505 , A61K31/53 , A61P5/24 , A61P5/36 , A61P5/42 , A61P9/12 , C07D213/74 , C07D239/10 , C07D239/42 , C07D239/46 , C07D239/48 , C07D239/50 , C07D239/52 , C07D239/58 , C07D251/46 , C07D401/04 , C07D405/12 , C07D405/14 , C07D471/04 , C07D487/04 , C07D491/052 , C07D491/056 , C07D239/32 , A61K31/50 , C07D239/70 , C07D487/02
Abstract: El invento se refiere a derivados de aminoácido de la formula I, en la que los radicales tienen el significado indicado en la descripcion, así como al uso de los mismos como medicamentos.
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公开(公告)号：PL325398A1
公开(公告)日：1998-07-20
申请号：PL32539896
申请日：1996-08-29
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , ELGER BERND , SCHULT SABINE
IPC: A61K31/00 , A61K31/19 , A61K31/192 , A61K31/34 , A61K31/341 , C07D317/02 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18
Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.
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公开(公告)号：HRP970198A2
公开(公告)日：1998-04-30
申请号：HRP970198
申请日：1997-04-11
Applicant: BASF AG
Inventor： KLINGE DAGMAR , AMBERG WILHELM , BAUMANN ERNST , KLING ANDREAS , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , SCHULT SABINE
IPC: A61K31/00 , A61K31/505 , A61K31/517 , A61P5/42 , A61P9/10 , A61P13/00 , A61P13/12 , C07D217/22 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/96 , C07D251/20 , C07D251/22 , C07D251/30 , C07D251/38 , C07D251/52 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044
Abstract: The present invention relates to carboxylic acid derivatives of the formulawhere the radicals have the meanings stated in the description, to the preparation of these compounds and to their use as drugs.
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公开(公告)号：AU688611B2
公开(公告)日：1998-03-12
申请号：AU3804595
申请日：1995-10-07
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , MULLER STEFAN , BAUMANN ERNST , RHEINHEIMER JOACHIM , VOGELBACHER UWE JOSEF , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048
Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.
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Patent Agency Ranking
公开(公告)号：NO981002D0
公开(公告)日：1998-03-06
申请号：NO981002
申请日：1998-03-06
Applicant: BASF AG
Inventor： AMBERG WILHELM , KLING ANDREAS , KLINGE DAGMAR , RIECHERS HARTMUT , UNGER LILIANE , RASCHACK MANFRED , HERGENROEDER STEFAN , ELGER BERND , SCHULT SABINE
IPC: A61K31/00 , A61K31/19 , C07D317/02 , A61K31/192 , A61K31/34 , A61K31/341 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/357 , A61K31/36 , A61K31/435 , A61K31/44 , A61K31/505 , A61P9/00 , A61P9/08 , C07C53/134 , C07C57/30 , C07C57/32 , C07C57/38 , C07C59/64 , C07C69/616 , C07C69/734 , C07C255/00 , C07D213/55 , C07D213/64 , C07D221/04 , C07D239/26 , C07D239/34 , C07D239/52 , C07D239/70 , C07D257/04 , C07D307/79 , C07D317/50 , C07D317/60 , C07D319/02 , C07D319/18
Abstract: PCT No. PCT/EP96/03793 Sec. 371 Date Feb. 24, 1998 Sec. 102(e) Date Feb. 24, 1998 PCT Filed Aug. 29, 1996 PCT Pub. No. WO97/09294 PCT Pub. Date Mar. 13, 1997Carboxylic acid derivatives of the formula I here R1 is a tetrazole [sic], nitrile [sic], a group COOH or a radical which can be hydrolyzed to COOH, and the other substituents have the meaning explained in the description.
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公开(公告)号：HRP950115A2
公开(公告)日：1997-10-31
申请号：HRP950115
申请日：1995-03-09
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROEGER BURGHARD , BIALOJAN SIEGRIED , BOLLSCHWEILER CLAUS , WERNET WOLFGANG , UNGER LILIANE , RESCHACK MANFRED
IPC: C07D251/26 , A61K31/00 , A61K31/505 , A61K31/506 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: PCT No. PCT/EP95/01099 Sec. 371 Date Sep. 30, 1996 Sec. 102(e) Date Sep. 30, 1996 PCT Filed Mar. 23, 1995 PCT Pub. No. WO95/26716 PCT Pub. Date Oct. 12, 1995A method of inhibiting endothelin receptors by administering to a patient a compound of the formula I I
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公开(公告)号：CA2250757A1
公开(公告)日：1997-10-23
申请号：CA2250757
申请日：1997-04-04
Applicant: BASF AG
Inventor： KLINGE DAGMAR , SCHULT SABINE , BAUMANN ERNST , AMBERG WILHELM , HERGENR DER STEFAN , RIECHERS HARTMUT , KLING ANDREAS , RASCHACK MANFRED , UNGER LILIANE
IPC: A61K31/00 , A61K31/505 , A61K31/517 , A61P5/42 , A61P9/10 , A61P13/00 , A61P13/12 , C07D217/22 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/56 , C07D239/60 , C07D239/70 , C07D239/80 , C07D239/96 , C07D251/20 , C07D251/22 , C07D251/30 , C07D251/38 , C07D251/52 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D251/12 , C07D401/12 , A61K31/44 , C07D239/46 , A61K31/53 , C07D213/62
Abstract: The present invention relates to carboxylic acid derivatives of the formula (I) in which the radicals have the meaning given in the description, the production of these compounds and their use as medicaments.
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公开(公告)号：MX9604448A
公开(公告)日：1997-07-31
申请号：MX9604448
申请日：1995-03-23
Applicant: BASF AG
Inventor： BAUMANN ERNST , VOGELBACHER UWE JOSEF , RHEINHEIMER JOACHIM , KLINGE DAGMAR , RIECHERS HARTMUT , KROGER BURKHARD , BIALOJAN SIEGFRIED , BOLLSCHWEILER CLAUS , WERNER WOLFGANG
IPC: A61K31/00 , A61K31/505 , A61K31/506 , C07D251/26 , A61K31/53 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , A61P39/02 , C07D239/26 , C07D239/34 , C07D239/38 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
Abstract: El presente invento se refiere a uso de determinados derivados de ácido carboxílico como medicamentos. La endotelina es un péptido compuesto de 21 aminoácidos, que es sintetizado y liberado por el endotelio vascular. La endotelina existe en tres formas isomeras, ET-1, ET-2 y ET-3. En lo sucesivo, el término "endotelina" o "ET" abarcará una o varias formas isomeras en la endotelina. La endotelina es un vasoconstrictor potente y tiene un fuerte efecto sobre el tono vascular. Es sabido, que esta constriccion vascular es producida por el ligamiento de la endotelina con su receptor.
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公开(公告)号：NO971675L
公开(公告)日：1997-06-10
申请号：NO971675
申请日：1997-04-11
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , MUELLER STEFAN , BAUMANN ERNST , RHEINHEIMER JOACHIM , VOGELBACHER UWE JOSEF , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D291/04
Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.
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