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公开(公告)号：DE59509541D1
公开(公告)日：2001-09-27
申请号：DE59509541
申请日：1995-10-07
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , MUELLER STEFAN , BAUMANN ERNST , RHEINHEIMER JOACHIM , VOGELBACHER JOSEF , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048
Abstract: Heterocyclyl-substd. propanoic acids and their derivs., of formula (I), are new. R = formyl, tetrazolyl, nitrile, COOH or a gp. that can be hydrolysed to COOH; X = N or CR14; R2 = H, OH, NH2, alkylamino, dialkylamino, halo, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; R14 = H or 1-5 C alkyl; R3 = R2 or alkoxyimino; or CR3 + CR14 = 5 or 6 membered alkylene or alkenyl ring (opt. substd. by 1-2 alkyl) in which a methylene can be replaced by O, S, NH or alkylamino; R4, R5 = phenyl or naphthyl (both opt. substd. by one or more halo, NO2, CN, OH, alkyl, haloalkyl, alkoxy, haloalkyloxy, phenoxy, alkylthio, NH2, alkylamine or dialkylamino) or 3-7 C cycloalkyl; or the phenyl or naphthyl gps. are opt. bonded at the O- position (by a bond, CH2, O, S, SO2, ethylene, ethenylene or opt. alkylated amino); R6 = H, 1-8 C alkyl, 2-6 C alkenyl, 3-6 C alkynyl, 3-8 C cycloalkyl (all opt. substd. by 1 or more halo, NO2, CN, alkoxy 3-6 C alkenyloxy, 3-6 C alkynyloxy, alkylthio, haloalkoxy, alkylcarbonyl, alkoxycarbonyl, 3-8 C alkylcarbonylalkyl, alkylamino, dialkylamino, phenyl, Ph or OPh), Ar or Het; Y = S, O or bond; Q = S, O, SO, SO2 or bond; Ph = substd. phenyl, where substits. are halo, NO2, CN, alkyl, haloalkyl, alkoxy, haloalkoxy or alkylthio; Ar = phenyl or naphthyl (both opt. substd. by 1 or more halo, NO2, CN, OH, NH2, alkylamino, dialkylamino or OCH2CH2O); Het = 5 or 6 membered heteroaromatic with 1-3 N atoms and/or one S or O (opt. substd. by 1-4 halo and/or 1 or 2 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, phenyl, phenoxy or phenyl carbonyl (where the phenyl is opt. substd. by 1-5 halo and/or 1-3 alkyl, haloalkyl, alkoxy, haloalkoxy and/or alkylthio)); alkyl and alkoxy have 1-4 C unless otherwise stated; provided that R6 is not H when Q = bond.
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公开(公告)号：DE59506734D1
公开(公告)日：1999-10-07
申请号：DE59506734
申请日：1995-05-09
Applicant: BASF AG
Inventor： KARL ULRICH , MUELLER STEFAN , DE POTZOLLI BERND
IPC: C07B61/00 , C07C227/18 , C07C229/12 , C07C269/06 , C07C271/22 , C07C323/59
Abstract: A process for preparing N-protected N-alkylated amino acids of the formula I:in which the substituents have the meanings stated in the description, comprises mixing a compound of the formula IIwith a solution of potassium tert-butanolate in a non-protic organic solvent, and subsequently adding a C1-2-alkyl halide.
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公开(公告)号：BR9611383A
公开(公告)日：1999-01-26
申请号：BR9611383
申请日：1996-10-30
Applicant: BASF AG
Inventor： RITTER KURT , BERNARD HARALD , HAUPT ANDREAS , AMBERG WILHELM , BUSCHMANN ERNST , JANSSEN BERND , MUELLER STEFAN , KLING ANDREAS , ROBINSON SIMON , ARRUDA MONIKA DE , BARLOZZARI TERESA , ZIERKE THOMAS
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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公开(公告)号：AT174035T
公开(公告)日：1998-12-15
申请号：AT95917962
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
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公开(公告)号：NO982100L
公开(公告)日：1998-05-08
申请号：NO982100
申请日：1998-05-08
Applicant: BASF AG
Inventor： KLING ANDREAS , JANSSEN BERND , AMBERG WILHELM , HAUPT ANDREAS , RITTER KURT , BUSCHMANN ERNST , BERNARD HARALD , MUELLER STEFAN , ZIERKE THOMAS , BARLOZZARI TERESA , ARRUDA MONIKA DE , ROBINSON SIMON
Abstract: Novel peptides of the formulaA-B-D-E-F-L,wherein A, B, D, E, F, and L have the meanings stated in the specification, and their preparation are disclosed. The novel compounds are suitable for controlling diseases.
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Patent Agency Ranking
公开(公告)号：ZA9606371B
公开(公告)日：1998-01-26
申请号：ZA9606371
申请日：1996-07-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , RITER KURT , ZIERKE THOMAS
CPC classification number: C07K7/06 , C07K5/06165 , C07K5/0808 , C07K5/101
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公开(公告)号：NO971675A
公开(公告)日：1997-06-10
申请号：NO971675
申请日：1997-04-11
Applicant: BASF AG
Inventor： RIECHERS HARTMUT , KLINGE DAGMAR , AMBERG WILHELM , KLING ANDREAS , MUELLER STEFAN , BAUMANN ERNST , RHEINHEIMER JOACHIM , VOGELBACHER UWE JOSEF , WERNET WOLFGANG , UNGER LILIANE , RASCHACK MANFRED
IPC: C07D251/30 , A61K31/505 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , A61P25/04 , C07D239/00 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/38 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/12 , C07D251/52 , C07D257/02 , C07D309/00 , C07D403/06 , C07D403/12 , C07D405/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/044 , C07D491/048 , C07D291/04
CPC classification number: C07D495/04 , C07D239/34 , C07D239/48 , C07D239/52 , C07D239/60 , C07D239/70 , C07D239/96 , C07D251/20 , C07D251/26 , C07D251/52 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D417/12 , C07D487/04 , C07D491/04 , C07D491/048
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公开(公告)号：HUT75861A
公开(公告)日：1997-05-28
申请号：HU9603067
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , DE POTZOLLI BERND , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号：CA2223911A1
公开(公告)日：1997-02-13
申请号：CA2223911
申请日：1996-07-12
Applicant: BASF AG
Inventor： RITTER KURT , KLING ANDREAS , MUELLER STEFAN , ZIERKE THOMAS , AMBERG WILHELM , JANSSEN BERND , KARL ULRICH , HAUPT ANDREAS , BUSCHMANN ERNST , BERNARD HARALD
IPC: C07K1/02 , C07K1/12 , C07K5/06 , C07K5/078 , C07K5/08 , C07K5/083 , C07K5/10 , C07K5/103 , C07K7/06 , C07K11/00 , C12P21/02
Abstract: The description relates to a process for producing pentapeptides of the formula (I) in which A and R1-R3 have the meanings given, in which the pentapeptide is constructed in steps from a prolinamide of the formula (II) in which R1 and R2 have the meanings given above, and the group -NR1R2 may be hydrolytically separated from the peptide thus obtained.
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公开(公告)号：HU9603067D0
公开(公告)日：1997-01-28
申请号：HU9603067
申请日：1995-04-26
Applicant: BASF AG
Inventor： AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , DE POTZOLLI BERND , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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