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    USE OF LACCASES AS REPORTER GENES
    6.
    发明申请
    USE OF LACCASES AS REPORTER GENES 审中-公开
    使用乳胶作为报告基因

    公开(公告)号：WO2006034811A3

    公开(公告)日：2006-06-22

    申请号：PCT/EP2005010239

    申请日：2005-09-22

    Applicant: BASF AG ,  KAROS MARVIN ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  NUESSLEIN BERNHARD ,  FISCHER REINHARD

    Inventor： KAROS MARVIN ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  NUESSLEIN BERNHARD ,  FISCHER REINHARD

    IPC: C12Q1/68 ,  C12N9/02

    CPC classification number: C12N9/12 ,  A01K2267/0393

    Abstract: Method for determining the regulatory properties of a genetic element, which comprises the following steps: a) introducing a DNA molecule having a DNA-I sequence whose regulatory properties are to be determined into a cell, said DNA-I sequence being linked with an additional DNA-II sequence encoding a laccase from Aspergillus nidulans in such a manner that the regulatory elements of the DNA-I sequence control expression of the laccase, b) cultivating the cells obtained in step (a) under conditions allowing expression of the laccase, c) associating the conditions selected under (b) with the regulatory properties of the DNA-I sequence.

    Abstract translation: 一种确定遗传元件调控性质的方法，包括以下步骤：a）向细胞中导入具有DNA序列的DNA分子，所述DNA分子的调节特性待测定，所述DNA序列具有DNA序列; 连接编码构巢曲霉漆酶的另一DNA II序列，使得DNA I序列的调节元件控制漆酶的表达，b）在（a）中获得的细胞在 允许漆酶表达，c）将（b）中选择的条件分配给DNA-1序列的调控性质。

    KERATIN-BINDING DESMOPLAKIN POLYPEPTIDE SEQUENCES
    7.
    发明申请
    KERATIN-BINDING DESMOPLAKIN POLYPEPTIDE SEQUENCES 审中-公开
    角蛋白BIKTDENDE DESMOPLAKINPOLYPEPTIDSEQUENZEN

    公开(公告)号：WO2006097432A3

    公开(公告)日：2007-04-19

    申请号：PCT/EP2006060607

    申请日：2006-03-09

    Applicant: BASF AG ,  BARG HEIKO ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  PTOCK ARNE

    Inventor： BARG HEIKO ,  SUBKOWSKI THOMAS ,  LEMAIRE HANS-GEORG ,  BOLLSCHWEILER CLAUS ,  PTOCK ARNE

    IPC: A61K8/64 ,  A61K38/17 ,  A61Q5/12

    CPC classification number: A61K38/1709 ,  A61K8/64 ,  A61Q1/02 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/002 ,  A61Q19/004 ,  A61Q19/10

    Abstract: The invention relates to novel keratin-binding protein materials and to their production and use. Particularly suitable keratin-binding polypeptides are those sequences that are contained in the human protein desmoplakin or that can be derived from modifications of human desmoplakin polypeptide sequences, such as amino acid insertions, substitutions or deletions. The polypeptide sequence of human desmoplakin is represented in SEQ ID NO: 1. A suitable keratin-binding domain (domain B) is the polypeptide sequence SEQ ID No: 1, position 2193 to 2481 and its functional equivalents. An additional keratin-binding domain (domain C) is the polypeptide sequence SEQ ID NO: 1, position 2606 to 2871 and its functional equivalents.

    Abstract translation: 本发明涉及新的角蛋白的结合蛋白的药物，其制备和用途。 特别合适的蝼锡结合多肽是包含在人类桥粒斑或通过修改人类Desmoplakinpolypeptidsequenzen如氨基酸插入，取代或它们的衍生缺失的那些序列。 人类桥粒斑蛋白的多肽序列为SEQ ID KO：1。 合适的角蛋白的结合结构域（结构域B）是该多肽序列SEQ ID WO：1点的位置2193至2481年，以及它们的功能等同物。 进一步的角蛋白的结合结构域（结构域C）是该多肽序列SEQ ID NO：1点的位置2606年至2871年，以及它们的功能等同物。

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