公开(公告)号：AU721923B2

公开(公告)日：2000-07-20

申请号：AU5375596

申请日：1996-03-27

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/133 ,  A61K8/14 ,  A61K8/70 ,  A61K9/127 ,  A61K41/00 ,  A61K47/30 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61K9/14

公开(公告)号：HK1019699A1

公开(公告)日：2000-02-25

申请号：HK99104828

申请日：1999-10-27

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61M5/00 ,  A61B20090101 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：AU709471B2

公开(公告)日：1999-08-26

申请号：AU2645495

申请日：1995-05-22

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/107 ,  A61K9/50 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  B01J13/00

Abstract: Novel stabilized suspensions of a gas as diagnostic contrast agents, including computed tomography (CT) and magnetic resonance (MR) contrast agents. In preferred embodiments, the suspensions comprise stabilized gas filled microspheres. Also in some preferred embodiments, at least a portion of the gas is derived from a gaseous precursor.

公开(公告)号：DE69033118D1

公开(公告)日：1999-06-24

申请号：DE69033118

申请日：1990-12-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B8/00 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  B01J13/02 ,  B01J13/12 ,  A61B8/14

Abstract: The present invention relates to a method for synthesizing a liposome having encapsulated therein a gas comprising contacting the liposomes in the liquid medium with gas under elevated pressure. The liposomes so produced and are useful in ultrasonic imaging techniques.

公开(公告)号：AU9136998A

公开(公告)日：1999-02-18

申请号：AU9136998

申请日：1998-11-05

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/50 ,  A61N7/02

公开(公告)号：AU7378798A

公开(公告)日：1998-12-08

申请号：AU7378798

申请日：1998-05-12

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K41/00 ,  A61K47/48 ,  A61K9/10

Abstract: The present invention is directed to a solid porous matrix comprising a solvent and a surfactant in combination with a bioactive agent. The solvent and the surfactant may, if desired, form vesicles, an agglomeration of which comprises the matrix. The composition optionally comprises a gas or a gaseous precursor. The emulsion may be dried, and subsequently reconstituted in an aqueous or organic solution. The present invention is also directed to a method of preparing a solid porous matrix comprising combining a solvent, a surfactant, and a therapeutic to form an emulsion; and processing the emulsion by controlled drying, or controlled agitation and controlled drying to form a solid porous matrix. The resulting solid porous matrix may also comprise a gas or gaseous precursor and be added to a resuspending medium. A method for the controlled delivery of a targeted therapeutic to a region of a patient is another embodiment of the present invention. The method comprises administering to the patient a composition having a solid porous matrix comprising a solvent, a surfactant, a therapeutic, and a gas or gaseous precursor, monitoring the composition using energy to determine the presence of the composition in the region; and releasing the therapeutic from the composition in the region using energy.

公开(公告)号：AU6974798A

公开(公告)日：1998-11-27

申请号：AU6974798

申请日：1998-04-15

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/127 ,  A61K41/00 ,  A61K49/22 ,  A61K31/56 ,  C07J5/00 ,  C07J7/00

公开(公告)号：AU698209B2

公开(公告)日：1998-10-29

申请号：AU3310395

申请日：1995-10-06

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B6/03 ,  A61B8/13 ,  A61K9/10 ,  A61K9/14 ,  A61K49/04 ,  A61K51/06 ,  A61K101/02 ,  A61P9/00 ,  B01J13/02 ,  C08K5/02 ,  C08L101/00 ,  G01N33/60

公开(公告)号：AU6185398A

公开(公告)日：1998-10-20

申请号：AU6185398

申请日：1998-02-25

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61K9/127 ,  A61K41/00 ,  A61K49/22 ,  A61K49/04 ,  A61K9/50

Abstract: The present invention is directed to charged lipids, compositions comprising charged lipids, and the use of these compositions in drug delivery, targeted drug delivery, therapeutic imaging and diagnostic imaging, as well as their use as contrast agents.

公开(公告)号：AU694973B2

公开(公告)日：1998-08-06

申请号：AU1221297

申请日：1997-01-17

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C

IPC: A61B17/00 ,  A61B17/22 ,  A61F7/00 ,  A61K9/127 ,  A61K41/00 ,  A61N7/02 ,  A61P29/00