公开(公告)号：EP0959908A4

公开(公告)日：2002-11-20

申请号：EP98946919

申请日：1998-09-09

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  GERTZ EDWARD W

IPC: A61K49/22 ,  A61K49/04 ,  A61K9/127 ,  A61K9/50 ,  A61K47/48

CPC classification number: A61K49/223 ,  A61K49/227 ,  A61K49/228 ,  B82Y5/00

公开(公告)号：CA2256592C

公开(公告)日：2010-06-01

申请号：CA2256592

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61K49/00 ,  A61M5/00 ,  A61B8/00 ,  A61B8/13 ,  A61K9/127 ,  A61K49/22 ,  A61K51/02 ,  A61M5/14

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：DK0712293T3

公开(公告)日：2003-06-30

申请号：DK94919208

申请日：1994-05-20

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  A61K37/22 ,  B01J13/02

Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：PT711127E

公开(公告)日：2003-04-30

申请号：PT94919184

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：AU696056B2

公开(公告)日：1998-08-27

申请号：AU6953794

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61K8/14 ,  A61K9/127 ,  A61K9/14 ,  A61K41/00 ,  A61K47/48 ,  A61K49/04 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B28B1/54

公开(公告)号：DE69431753T3

公开(公告)日：2009-07-09

申请号：DE69431753

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing gas-filled liposomes are described. Gas-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.

公开(公告)号：ES2187524T5

公开(公告)日：2009-05-04

申请号：ES94919184

申请日：1994-05-19

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K48/00 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: METODO Y APARATO PARA PREPARAR LIPOSOMAS LLENADOS CON GAS. ESTOS LIPOSOMAS SON PARTICULARMENTE UTILES, POR EJEMPLO, EN LAS APLICACIONES DE REALIZACION DE IMAGENES ULTRASONICAS Y EN LOS SISTEMAS DE ENVIO DE MEDICAMENTOS TERAPEUTICOS.

公开(公告)号：AU5627198A

公开(公告)日：1998-05-07

申请号：AU5627198

申请日：1998-02-24

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61K9/127 ,  A61K49/00 ,  A61K51/12

公开(公告)号：AU3313197A

公开(公告)日：1998-01-07

申请号：AU3313197

申请日：1997-06-16

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  MATSUNAGA TERRY O ,  FRITZ THOMAS A ,  RAMASWAMI VARADA RAJAN

IPC: A61M5/00 ,  A61B8/00 ,  A61K49/00 ,  A61K49/22 ,  A61K51/02 ,  A61B5/055

Abstract: Methods for providing an image of an internal region of a patient. Embodiments of the methods involve administering to the patient a contrast agent which comprises a vesicle composition comprising, in an aqueous carrier, a gas or gaseous precursor and vesicles comprising lipids, proteins or polymers. The patient is scanned using diagnostic imaging, such as ultrasound, to obtain a visible image of the region. The contrast agent is administered to the patient at a rate to substantially eliminate diagnostic artifacts in the image. The methods are particularly useful for diagnosing the presence of any diseased tissue in the patient.

公开(公告)号：ES2193161T3

公开(公告)日：2003-11-01

申请号：ES94919208

申请日：1994-05-20

Applicant: IMARX PHARMACEUTICAL CORP

Inventor： UNGER EVAN C ,  FRITZ THOMAS A ,  MATSUNAGA TERRY ,  RAMASWAMI VARADARAJAN ,  YELLOWHAIR DAVID ,  WU GUANLI

IPC: A61B8/00 ,  A61K8/14 ,  A61K9/127 ,  A61K41/00 ,  A61K47/48 ,  A61K49/00 ,  A61K49/18 ,  A61K49/22 ,  A61M5/31 ,  A61Q19/00 ,  B01J13/02

Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.