公开(公告)号：EP2278933A4

公开(公告)日：2017-08-09

申请号：EP09742997

申请日：2009-05-04

Applicant: STC UNM

Inventor： LUAN SHUANG ,  SWANSON NATHAN ,  MA LIJUN

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61B34/10 ,  A61B90/10 ,  A61B2090/101 ,  A61N5/103 ,  A61N5/1042 ,  A61N5/1084

Abstract: The present invention is a method and system for developing a dynamic scheme for Gamma Knife radiosurgery based on the concept of "dose-painting" to take advantage of robotic patient positioning systems on the Gamma Knife C and Perfexion units. The spherical high dose volume created by the Gamma Knife unit will be viewed as a 3D spherical "paintbrush", and treatment planning is reduced to finding the best route of this "paintbrush" to "paint" a 3D tumor volume. Under the dose-painting concept, Gamma Knife radiosurgery becomes dynamic, where the patient is moving continuously under the robotic positioning system.

Abstract translation: 本发明是基于“剂量绘画”概念开发用于伽玛刀放射手术的动态方案以利用伽马刀C和Perfexion单元上的机器人患者定位系统的方法和系统。 由伽玛刀单元创建的球形高剂量体积将被视为3D球形“画笔”，并且治疗计划被缩减为找到该“画笔”来“绘制”3D肿瘤体积的最佳路线。 在剂量绘画的概念下，伽玛刀放射手术变得动态，患者在机器人定位系统下持续移动。

公开(公告)号：EP2981611A4

公开(公告)日：2016-11-16

申请号：EP14779421

申请日：2014-04-02

Applicant: STC UNM ,  SANDIA CORP

Inventor： ASHLEY CARLEE ERIN ,  CARNES ERIC C ,  WU TERRY ,  FELTON LINDA A ,  SASAKI DARRYL Y

IPC: C12N11/14 ,  A61K9/127 ,  A61K9/51 ,  A61K35/66 ,  A61K47/48 ,  A61P31/00 ,  C12N11/08

CPC classification number: A61K47/48823 ,  A61K9/0053 ,  A61K9/1271 ,  A61K9/1274 ,  A61K9/5021 ,  A61K9/5123 ,  A61K31/505 ,  A61K31/5383 ,  A61K31/546 ,  A61K31/635 ,  A61K31/65 ,  A61K31/7036 ,  A61K47/48015 ,  A61K47/48238 ,  A61K47/48369 ,  A61K47/48838 ,  A61K47/48861 ,  A61K47/52 ,  A61K47/60 ,  A61K47/62 ,  A61K47/68 ,  A61K47/6913 ,  A61K47/6917 ,  A61K47/6923 ,  A61K47/6929 ,  B82Y5/00

Abstract: The invention provides novel antibiotic protocells comprising mesoporous nanoparticles encapsulated within a lipid bi- or multilayer. The nanoparticles have pore sizes and surface chemistries that enable facile adsorption and intracellular presentation of antibiotics which are effective in the treatment of a wide variety of bacterial infections, including F. tularensis, B. pseudomallei and P. aeruginosa-related infections. Related pharmaceutical compositions and methods of treatment are also provided.

Abstract translation: 本发明提供了包含在脂质双层或多层中的介孔纳米颗粒的新型抗生素原细胞。 纳米颗粒具有孔径和表面化学性质，其能够容易地吸附和细胞内呈递抗生素，其有效治疗各种细菌感染，包括土拉木霉，假单胞菌和铜绿假单胞菌相关感染。 还提供了相关的药物组合物和治疗方法。

公开(公告)号：EP2945735A4

公开(公告)日：2016-06-22

申请号：EP14740852

申请日：2014-01-16

Applicant: STC UNM

Inventor： SEROV ALEXEY ,  ATANASSOV PLAMEN B

IPC: H01M4/90 ,  B01J27/24 ,  B01J35/00 ,  B01J35/10 ,  B01J37/00 ,  B01J37/06 ,  B01J37/08

CPC classification number: H01M4/9041 ,  B01J27/24 ,  B01J35/0033 ,  B01J35/10 ,  B01J37/0036 ,  B01J37/06 ,  B01J37/086 ,  H01M4/9091

Abstract: A sacrificial support-based method, a mechanosynthesis-based method, and a combined sacrificial support/mechanosynthesis support based method that enables the production of supported or unsupported catalytic materials and/or the synthesis of catalytic materials from both soluble and insoluble transition metal and charge transfer salt materials.

Abstract translation: 基于牺牲支持的方法，基于机械合成的方法和基于组合的牺牲支持/机械合成支持的方法，其能够从可溶性和不溶性过渡金属和电荷中产生负载或未负载的催化材料和/或催化材料的合成 转盐材料。

公开(公告)号：EP2782672A4

公开(公告)日：2015-09-09

申请号：EP12852129

申请日：2012-11-21

Applicant: STC UNM ,  LUHRS CLAUDIA CATALINA ,  BROSHA ERIC ,  PHILLIPS JONATHAN

Inventor： LUHRS CLAUDIA CATALINA ,  BROSHA ERIC ,  PHILLIPS JONATHAN

IPC: B01J37/08 ,  B01J6/00 ,  B01J23/40 ,  B01J23/44

CPC classification number: B01J23/42 ,  B01J21/04 ,  B01J21/063 ,  B01J21/18 ,  B01J23/44 ,  B01J23/745 ,  B01J23/755 ,  B01J35/002 ,  B01J35/006 ,  B01J35/0093 ,  B01J35/1014 ,  B01J35/1028 ,  B01J37/0036 ,  B01J37/04 ,  B01J37/16 ,  H01M4/88 ,  H01M4/8842 ,  H01M4/9041 ,  H01M4/925 ,  H01M4/926

公开(公告)号：EP2734191A4

公开(公告)日：2015-04-29

申请号：EP12815024

申请日：2012-07-18

Applicant: STC UNM

Inventor： ZEINELDEN REEMA

IPC: A61K9/16 ,  A61K9/14 ,  A61K9/22 ,  A61K47/30 ,  A61K47/48 ,  A61P35/00

CPC classification number: A61K9/127 ,  A61K9/0019 ,  A61K9/5115 ,  A61K9/5153 ,  A61K31/704 ,  Y10S977/773 ,  Y10S977/906 ,  Y10S977/907 ,  Y10S977/911

公开(公告)号：EP2701686A4

公开(公告)日：2014-11-05

申请号：EP12776480

申请日：2012-04-27

Applicant: STC UNM ,  SANDIA CORP

Inventor： BRINKER JEFFREY C ,  CARNES ERIC C ,  ASHLEY CARLEE ERIN

IPC: A61K9/16 ,  A61K9/127 ,  A61K38/17 ,  A61K47/30 ,  A61K47/48 ,  A61K48/00 ,  C07K14/47 ,  C12N15/88

CPC classification number: A61K9/1271 ,  A61K31/704 ,  A61K31/711 ,  A61K33/24 ,  A61K38/00 ,  A61K39/05 ,  A61K45/06 ,  A61K47/62 ,  A61K47/6901 ,  A61K48/0016 ,  C07K14/47 ,  C12N15/1135 ,  C12N15/88 ,  C12N2310/14 ,  C12N2320/32 ,  C12N2810/40

Abstract: The present invention is directed to protocells for specific targeting of hepatocellular and other cancer cells which comprise a nanoporous silica core with a supported lipid bilayer; at least one agent which facilitates cancer cell death (such as a traditional small molecule, a macromolecular cargo (e.g. siRNA or a protein toxin such as ricin toxin A-chain or diphtheria toxin A-chain) and/or a histone-packaged plasmid DNA disposed within the nanoporous silica core (preferably supercoiled in order to more efficiently package the DNA into protocells) which is optionally modified with a nuclear localization sequence to assist in localizing protocells within the nucleus of the cancer cell and the ability to express peptides involved in therapy (apoptosis/cell death) of the cancer cell or as a reporter, a targeting peptide which targets cancer cells in tissue to be treated such that binding of the protocell to the targeted cells is specific and enhanced and a fusogenic peptide that promotes endosomal escape of protocells and encapsulated DNA. Protocells according to the present invention may be used to treat cancer, especially including hepatocellular (liver) cancer using novel binding peptides (c-MET peptides) which selectively bind to hepatocellular tissue or to function in diagnosis of cancer, including cancer treatment and drug discovery.

公开(公告)号：EP2519627A4

公开(公告)日：2013-12-18

申请号：EP10841780

申请日：2010-12-31

Applicant: STC UNM

Inventor： PEABODY DAVID S ,  CHACKERIAN BRYCE

IPC: C12N7/01 ,  A61K39/12 ,  C07K14/005 ,  C12N15/33

CPC classification number: A61K39/12 ,  A61K39/07 ,  A61K2039/5256 ,  A61K2039/5258 ,  C12N7/00 ,  C12N15/1037 ,  C12N2710/20022 ,  C12N2710/20034 ,  C12N2740/16034 ,  C12N2740/16134 ,  C12N2795/16021 ,  C12N2795/16022 ,  C12N2795/16023 ,  C12N2795/16042 ,  C12N2795/18023 ,  C40B40/08

Abstract: The present invention relates to a system and method for controlling peptide display valency on virus-like particles (VLPs), especially including MS2 VLPs. In this method, large amounts of wild-type and low quantities of single-chain dimer coat proteins may be produced from a single RNA. Valency is controlled in immunogen (vaccine) production by providing a system that allows the production of large amounts of wild-type and low quantities of single-chain dimer coating proteins from a single RNA, allowing facile adjustment of display valency levels on VLPs, especially MS2 VLPS over a wide range, from few than one—on average—to as many as ninety per particle. This facilitates the production of immunogens and vaccines, including VLPs exhibiting low valency. Nucleic acid constructs useful in the expression of virus-like particles are disclosed, comprised of a coat polypeptide of MS2 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates MS2 niRNA. Nucleic acid constructs are also disclosed which are useful in the expression of virus-like particles comprised of a coat polypeptide of PP7 modified by insertion of a heterologous peptide, wherein the heterologous peptide is displayed on the virus-like particle and encapsidates PP7 mRNA.

公开(公告)号：EP2470167A4

公开(公告)日：2013-08-14

申请号：EP10815900

申请日：2010-08-27

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN J

IPC: A61K9/28 ,  A61K9/12 ,  A61K9/14

CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

公开(公告)号：EP2097087A4

公开(公告)日：2013-01-02

申请号：EP07867365

申请日：2007-11-06

Applicant: STC UNM

Inventor： DU CLOS TERRY W ,  MOLD CAROLYN

IPC: A61K35/14 ,  A61K35/12 ,  A61K35/28 ,  A61K38/17 ,  A61P37/02

CPC classification number: A61K35/15 ,  A61K35/28 ,  A61K38/1745 ,  A61K2300/00

Abstract: The present invention relates to the use of suppressive macrophage or dendritic cells (activated with C-reactive protein or CRP-related compounds), for the treatment of various disease states and conditions associated with immune thrombocytopenic purpura (ITP) and/or systemic lupus erythematosus (SLE), including lupus of the skin (discoid), systemic lupus of the joints, lungs and kidneys, hematological conditions including hemolytic anemia and low lymphocyte counts, lymphadenopathy and CNS effects, including memory loss, seizures and psychosis, among numerous others as otherwise disclosed herein. In another aspect of the invention, the reduction in the likelihood that a patient who is at risk for an outbreak of a disease state or condition associated with systemic lupus erythematosus or ITP will have an outbreak is an additional aspect of the present invention. In the case of ITP, methods of the present invention are used to increase platelet counts in the treated patient. In addition, in the case of ITP, the present invention relates to the use of CRP or a CRP-related compound in the absence of suppressive macrophages for the treatment of ITP.

公开(公告)号：EP2231019A4

公开(公告)日：2011-08-10

申请号：EP08860441

申请日：2008-12-10

Applicant: STC UNM

Inventor： CHEN JINGKUANG

IPC: A61B5/00 ,  A61B8/08 ,  A61B8/12

CPC classification number: A61B5/0095 ,  A61B5/0086 ,  A61B5/02007 ,  A61B8/0833 ,  A61B8/12 ,  A61B8/4472 ,  A61B8/4483 ,  A61B8/483 ,  A61B2562/028 ,  Y10T29/49826