公开(公告)号：WO2011112531A3

公开(公告)日：2012-01-05

申请号：PCT/US2011027465

申请日：2011-03-08

Applicant: STC UNM ,  MAYNARD NICOLA JEANNE ,  SMYTH HUGH D C

Inventor： MAYNARD NICOLA JEANNE ,  SMYTH HUGH D C

IPC: A61M11/02 ,  A61J1/05 ,  A61M15/00

CPC classification number: A61M15/0086 ,  A61M11/003 ,  A61M15/00 ,  A61M15/0006 ,  A61M15/0021 ,  A61M15/003 ,  A61M15/0035 ,  A61M15/009 ,  A61M2016/0015 ,  A61M2202/064 ,  A61M2205/0272 ,  A61M2205/8287 ,  A61M2206/16

Abstract: A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically- responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

Abstract translation: 干粉递送装置可以被配置为向使用者的气道提供微粉化的干粉颗粒。 该装置可以包括限定包含至少一个磁响应物体的腔室的圆柱形容器，在该腔室外部的电动机，该腔室外部的磁体并与该电动机可旋转地联接，以及流出部件，其将气流引导至使用者 。 磁性响应物体可以涂覆有微粉化的干粉末颗粒，并且电动机可操作以使磁体围绕轴线旋转。 磁体的旋转产生磁场，使得响应于磁场的磁响应物体移动并与容器的侧壁碰撞，以使干粉颗粒解聚并使空腔中的干粉雾化。

公开(公告)号：WO2010014827A3

公开(公告)日：2010-04-29

申请号：PCT/US2009052277

申请日：2009-07-30

Applicant: STC UNM ,  SMYTH HUGH D C ,  DONOVAN MARTIN

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 µm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

Abstract translation: 干粉吸入器可以包括药物腔室，该药物腔室构造成容纳包括载体颗粒和工作剂颗粒的制剂，构造成引导工作剂颗粒流向使用者的嘴部和靠近嘴部件的保持构件。 保持构件的尺寸和布置被设置成防止基本上所有载体颗粒流向使用者，同时允许工作剂颗粒流向使用者。 吸入器可以包括含有载体颗粒的制剂，用于将工作剂递送至患者的肺部系统。 载体颗粒可具有大于约500μm的平均筛直径。 载体颗粒可以是聚苯乙烯，PTFE，硅酮玻璃，硅胶或玻璃中的一种。

公开(公告)号：EP2470167A4

公开(公告)日：2013-08-14

申请号：EP10815900

申请日：2010-08-27

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN J

IPC: A61K9/28 ,  A61K9/12 ,  A61K9/14

CPC classification number: A61K9/0075 ,  A61K9/14 ,  A61K31/58

公开(公告)号：CA2779488A1

公开(公告)日：2011-05-19

申请号：CA2779488

申请日：2010-11-12

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

IPC: A61M15/00 ,  A61M11/02

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

公开(公告)号：CA2770714A1

公开(公告)日：2011-03-17

申请号：CA2770714

申请日：2010-08-27

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN J

IPC: A61K9/28 ,  A61K9/12 ,  A61K9/14

Abstract: A method of method of coating powdered medical agent onto a carrier particle for use in a dry powder inhaler may include applying ultrasonic energy to agglomerated powdered medical agent to deaggregate and aerosolize particles of the medical agent into particles having a desired average particle size, and coating at least one carrier particle with a desired amount of the deaggregated and aerosolized particles of the medical agent.

公开(公告)号：EP2328556A4

公开(公告)日：2013-11-20

申请号：EP09803599

申请日：2009-07-30

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: A61K9/14

CPC classification number: A61K9/0075 ,  Y10T428/2982

Abstract: A dry powder inhaler may include a drug chamber configured to contain a formulation including carrier particles and working agent particles, a mouthpiece configured to direct flow of working agent particles to a user, and a retaining member proximal the mouthpiece. The retaining member be sized and arranged to prevent flow of substantially all carrier particles to the user while permitting flow of working agent particles to a user. The inhaler may include a formulation including carrier particles for delivering working agent to the pulmonary system of a patient. The carrier particles may have an average sieve diameter greater than about 500 μm. The carrier particles may be one of polystyrene, PTFE, silicone glass, and silica gel or glass.

公开(公告)号：AU2011224397A1

公开(公告)日：2012-09-06

申请号：AU2011224397

申请日：2011-03-09

Applicant: STC UNM

Inventor： SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: B05B7/14 ,  B05B7/02 ,  B05B7/24 ,  B05B15/00

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

公开(公告)号：AU2010319328A1

公开(公告)日：2012-05-31

申请号：AU2010319328

申请日：2010-11-12

Applicant: STC UNM

Inventor： SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

IPC: A61M15/00 ,  A61M11/02

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

公开(公告)号：WO2011060334A3

公开(公告)日：2011-09-22

申请号：PCT/US2010056628

申请日：2010-11-12

Applicant: STC UNM ,  SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

Inventor： SMYTH HUGH D C ,  SELVAM PARTHIBAN ,  TRUMAN CHARLES RANDALL

IPC: A61M15/00 ,  A61M11/02

CPC classification number: A61M15/0028 ,  A61M11/003 ,  A61M15/0031 ,  A61M15/0038 ,  A61M15/0086 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2206/16

Abstract: A dry powder inhaler including a housing defining a chamber for receiving a dose of powdered medicament, an inhalation port in fluid communication with the chamber, at least one airflow inlet providing fluid communication between the chamber and an exterior of the housing, and a flutter element in the chamber and associated with a dose of powdered medicament. The flutter element has a tensioned distal end proximate the at least one airflow inlet and a free proximal end opposite to the distal end and downstream of the inlet. The flutter element is configured to vibrate in response to airflow through the chamber and aerosolize the dose of powdered medicament.

Abstract translation: 一种干粉吸入器，包括限定用于接收一定剂量的粉末药物的腔室的壳体，与腔室流体连通的吸入口，至少一个气流入口，其提供腔室与外壳之间的流体连通，以及颤动元件 并且与一定剂量的粉末状药物相关联。 颤振元件具有靠近至少一个气流入口的张紧的远端和与入口的远端和下游相对的自由近端。 颤振元件构造成响应于通过腔室的气流而振动并使粉末状药物的剂量雾化。

公开(公告)号：WO2011112756A2

公开(公告)日：2011-09-15

申请号：PCT/US2011027797

申请日：2011-03-09

Applicant: STC UNM ,  SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

Inventor： SELVAM PARTHIBAN ,  SMYTH HUGH D C ,  DONOVAN MARTIN

IPC: B05B7/14 ,  B05B7/02 ,  B05B7/24 ,  B05B15/00

CPC classification number: B05B7/144 ,  A61M15/0028 ,  A61M15/0065 ,  A61M15/009 ,  A61M2202/064 ,  A61M2205/0233 ,  A61M2205/0238 ,  B05B13/0207 ,  B05B15/0443

Abstract: A device for coating dry powder microparticles onto a surfacemay include a jet mill configured to mill dry powder particles into microparticles having a desired aerodynamic diameter and to deaggregate the microparticles, a feed hopper structured and arranged to feed dry powder particles to the jet mill, a surface configured to receive dry powder microparticles and an exit nozzle associated with the jet mill. The exit nozzle may be arranged to direct deaggregated micronized dry powder particles from the jet mill to the surface to be coated. The device may further include a holder structured and arranged to hold an item, wherein the item includes the surface. In some aspects of the device, the item may be a film.

Abstract translation: 用于将干燥粉末微粒涂覆到表面上的装置包括喷射式粉碎机，其被配置为将干燥粉末颗粒研磨成具有期望空气动力学直径的微粒并使微粒解聚，构造并布置成将干燥粉末颗粒送入喷射式粉碎机的进料斗， 表面构造成接收干粉微粒和与喷射磨相关联的出口喷嘴。 出口喷嘴可以布置成将来自喷射磨机的解聚集的微粉化干粉颗粒引导到待涂覆的表面。 该装置还可以包括构造和布置成保持物品的保持器，其中物品包括表面。 在设备的某些方面，该项目可以是电影。