-
公开(公告)号:CA2805586C
公开(公告)日:2020-09-01
申请号:CA2805586
申请日:2011-07-15
Applicant: STICHTING VU VUMC
Inventor: WUERDINGER THOMAS , NILSSON ROLF JONAS
IPC: G01N33/48
Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.
-
132.
公开(公告)号:NL2016085B1
公开(公告)日:2017-07-24
申请号:NL2016085
申请日:2016-01-13
Applicant: STICHTING VU-VUMC
Inventor: BOB WILHELM VAN DIJK
IPC: A61B3/08
Abstract: The invention relates to a method, system and computer readable medium for determining a strabismus angle of the eyes of an individual by: positioning the individual with his or her eyes in front of an eye tracker device and in front of a screen at a viewing distance; displaying a small image element on the screen; measuring a position and line of sight of the eyes of the individual with the eye tracker device while the individual is focussing on the small image element; forwarding the measured position and line of sight of the eyes from the eye tracker device to a computer system; and, calculating the strabismus angle between the eyes by calculating the difference in line of sight of the left and right eyes of the individual.
-
公开(公告)号:NL2016018B1
公开(公告)日:2017-07-03
申请号:NL2016018
申请日:2015-12-23
Applicant: STICHTING VU-VUMC
Inventor: KEITH SEAN COVER
IPC: G01R33/50
Abstract: A method for reconstructing an unknown T1 spectrum from signals dependent on T1. The method can be applied to MRI imaging in vivo measurements including for clinical diagnosis, oil well logging, laboratory measurements, properties of materials and other areas were magnetic resonance measurements are informative. A related method can also be used to reconstruct a T2/T1 spectrum from signals dependent on T2/T1.
-
公开(公告)号:BR112014000113A2
公开(公告)日:2017-02-14
申请号:BR112014000113
申请日:2012-07-04
Applicant: STICHTING VU-VUMC , VEENHOF MEDICAL DEVICES B V
Abstract: resumo patente de invenção: "sistema e método para prever a viabilidade de um tecido corporal em um paciente e um dispositivo de medição usado no mesmo". a presente invenção refere-se a um sistema para prever a viabilidade de um tecido corporal em um paciente. o sistema compreende um dispositivo de computação (1), e um primeiro dispositivo de medição de pressão (2) para medir a pressão de perfusão local no tecido corporal do paciente. esse dispositivo de medição está conectado ao dispositivo de computação. um segundo dispositivo de medição de pressão (5) é fornecido para medir a pressão de perfusão sistêmica do paciente, sendo que o dito segundo dispositivo de medição de pressão é conectado ao dispositivo de computação. um indicador de retroalimentação (6) é conectado ao dispositivo de computação e é adaptado para indicar a viabilidade do tecido calculada pelo dispositivo de computação com base no local de medição é nas pressões da perfusão sistêmica. a invenção inclui, ainda, um método de previsão da viabilidade do tecido corporal e do primeiro dispositivo de medição de pressão.
-
公开(公告)号:NL2013049B1
公开(公告)日:2016-07-07
申请号:NL2013049
申请日:2014-06-20
Applicant: STICHTING TECHNISCHE WETENSCHAPPEN , STICHTING VU-VUMC , ACADEMISCH ZIEKENHUIS GRONINGEN , UNIV GRONINGEN , BIOFORDRUG SRL SPIN-OFF DELL'UNIVERSITÀ DEGLI STUDI DI BARI
Inventor: GERT LUURTSEMA , ALBERT DIRK WINDHORST , HELI SAVOLAINEN , NICOLA ANTONIO COLABUFO , MARIANGELA CANTORE
IPC: A61K51/00
Abstract: The present invention relates to a 6,7-Dioxyalkyltetrahydroisoquinoline compound, or a salt or solvate thereof according to formula I: (I) wherein R1 represents hydrogen or a fluorinated alkyl group, and R2 and R3 independently represents hydrogen or an alkyl group, a radiopharmaceutical composition comprising the compound, or a salt or solvate thereof, and a method for the in vivo diagnosis or imaging of P-gp related disease or behaviour comprising administration of a compound according to the invention, or a formulation comprising the compound.
-
公开(公告)号:NL2012967B1
公开(公告)日:2016-06-27
申请号:NL2012967
申请日:2014-06-06
Applicant: STICHTING VU-VUMC , FOM-NIKHEF
Abstract: A MEMS sensor comprising preloaded suspension springs and a method for mechanically preloading suspension springs of a MEMS sensor are described. The MEMS sensor comprises a MEMS support structure; a plurality of suspension springs connected to said support structure; and, a proof mass flexibly suspended by said suspension springs; wherein at least one of said suspension springs is mechanically preloaded with a compressive force for reducing the natural frequency of said proof mass.
-
公开(公告)号:NL2011087C
公开(公告)日:2015-01-06
申请号:NL2011087
申请日:2013-07-03
Applicant: STICHTING VU VUMC
Inventor: WUITE GIJS JAN LODEWIJK , PETERMAN ERWIN JOHANNES GERARD , HELLER IDDO , SITTERS GERRIT , CANDELLI ANDREA , HELL STEFAN WALTER
CPC classification number: G01N21/6458 , B01L3/502761 , C12Q1/6816 , G02B21/0048 , G02B21/0076 , G02B21/16 , G02B21/32 , C12Q2523/303 , C12Q2565/601 , C12Q2565/607
-
公开(公告)号:NL2010960C2
公开(公告)日:2014-12-15
申请号:NL2010960
申请日:2013-06-12
Applicant: STICHTING VU VUMC
Abstract: A molecular manipulation system for investigating molecules, having a sample holder constructed to hold a sample comprising a plurality of molecules attached on one side to a surface in the sample holder and on another side attached to a microbead of a plurality of microbeads. The system having; an acoustic wave generator to generate an acoustic wave exerting a force on the microbeads in the sample; and a detector device to detect a response of the plurality of microbeads in the sample on the force exerted by the acoustic wave to investigate the molecules attached to the microbeads.
-
公开(公告)号:NL2010036C2
公开(公告)日:2014-06-24
申请号:NL2010036
申请日:2012-12-21
Applicant: STICHTING TECH WETENSCHAPP , STICHTING VU VUMC , UNIV GRONINGEN , GRONINGEN ACAD ZIEKENHUIS
Inventor: RAAPHORST RENSKE , LUURTSEMA GERT , WINDHORST ALBERT DIRK , LAMMERTSMA ADRIAAN
IPC: A61K31/277 , A61K51/04 , A61K101/02 , C07B59/00
-
公开(公告)号:AU2012231884A2
公开(公告)日:2014-05-08
申请号:AU2012231884
申请日:2012-01-16
Applicant: STICHTING VU VUMC , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG
Inventor: WURDINGER THOMAS , NILSSON ROLF JONAS
IPC: G01N33/48
Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.
-
-
-
-
-
-
-
-
-