公开(公告)号：WO2014117253A1

公开(公告)日：2014-08-07

申请号：PCT/CA2014/000062

申请日：2014-01-28

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： GANG, Zheng ,  HUYNH, Elizabeth ,  NG, Kenneth ,  SHAKIBA, Mojdeh ,  WEERSINK, Robert ,  WILSON, Brian

IPC: A61K49/22 ,  A61K47/22 ,  A61K47/24 ,  A61K49/00

CPC classification number: A61K49/227 ,  A61K49/0036 ,  A61K49/0052 ,  A61K49/0084 ,  A61K49/221

Abstract: There is provided herein a nanovesicle having a bilayer comprising a saturated first phospholipid and no more than about 15 molar % of a second phospholipid covalently conjugated to a J-aggregate forming dye.

Abstract translation: 本文提供了具有包含饱和第一磷脂和不超过约15摩尔％的与J-骨料形成染料共价缀合的第二磷脂的双层的纳米囊。

公开(公告)号：WO2014107798A1

公开(公告)日：2014-07-17

申请号：PCT/CA2014/000009

申请日：2014-01-13

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： ALSHAER, Hisham ,  FERNIE, Geoffrey Roy ,  BRADLEY, T. Douglas ,  LEVCHENKO, Oleksandr Igorovich

IPC: A61B5/08 ,  A61B5/087 ,  A61M16/00

CPC classification number: A61B5/6803 ,  A61B5/0803 ,  A61B5/087 ,  A61B5/097 ,  A61B5/1116 ,  A61B5/4818 ,  A61B5/7264 ,  A61B5/7282 ,  A61B7/003 ,  A61B2562/0219 ,  A61B2562/0247 ,  A61B2562/028 ,  A61M16/021 ,  A61M16/06 ,  A61M16/0633 ,  A61M2016/0027 ,  A61M2016/0033 ,  A61M2205/18 ,  A61M2205/332 ,  A61M2205/3375 ,  A61M2205/505 ,  A61M2205/52 ,  A61M2230/40 ,  A61M2230/63

Abstract: Disclosed herein are breathing disorder identification, characterization and diagnosis methods, devices and systems. A mask is also disclosed for use in respiratory monitoring, characterization and/or diagnosis. In some embodiments, breath sound data are acquired concurrently with positional data to characterize a position dependence of a subject's breathing disorder.

Abstract translation: 本文公开了呼吸障碍识别，表征和诊断方法，装置和系统。 还公开了用于呼吸监测，表征和/或诊断的面罩。 在一些实施例中，呼吸声音数据与位置数据同时获取以表征受试者的呼吸障碍的位置依赖性。

公开(公告)号：WO2014075168A1

公开(公告)日：2014-05-22

申请号：PCT/CA2013/000957

申请日：2013-11-15

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： LIU, Yong ,  PAULS, Heinz W. ,  LAUFER, Radoslaw ,  LI, Sze-Wan ,  SAMPSON, Peter Brent ,  FEHER, Miklos ,  NG, Grace ,  PATEL, Narendra Kumar B. ,  LANG, Yunhui

IPC: C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC classification number: C07D487/04 ,  C07D519/00

Abstract: The present teachings provide a compound represented by structural formula (1-0), or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof.

Abstract translation: 本发明提供由结构式（1-0）表示的化合物或其药学上可接受的盐。 还描述了药物组合物及其使用方法。

公开(公告)号：WO2013163739A1

公开(公告)日：2013-11-07

申请号：PCT/CA2013/000432

申请日：2013-04-30

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： KELLER, Gordon ,  NOSTRO, Maria Cristina ,  HOLTZINGER, Audrey ,  SARANGI, Farida

IPC: C12N5/071 ,  C12N5/02 ,  C12N5/073 ,  C12P21/02

CPC classification number: C12N5/0678 ,  A61K35/39 ,  C12N5/0676 ,  C12N2500/38 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/155 ,  C12N2501/385 ,  C12N2501/40 ,  C12N2501/415 ,  C12N2502/28 ,  C12N2506/02 ,  C12N2506/45

Abstract: Methods and compositions for producing NKX6-1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population, the method comprising contacting the endodermal cell population with an EGF component, a Nicotinamide component and/or a Noggin component, optionally a combination of at least one EGF component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a NKX6-1+ pancreatic progenitor cell, the combination optionally further comprising at least one Noggin component.

Abstract translation: 用于从内胚层细胞群产生NKX6-1 +胰腺祖细胞和/或产生胰岛素的细胞的方法和组合物，所述方法包括使内胚层细胞群体与EGF组分，烟酰胺组分和/或Noggin组分，任选的组合 的至少一种EGF组分和至少一种烟酰胺组分以诱导至少一种内胚层细胞分化成NKX6-1 +胰腺祖细胞，所述组合任选地还包含至少一种Noggin组分。

公开(公告)号：WO2013106913A1

公开(公告)日：2013-07-25

申请号：PCT/CA2013/000042

申请日：2013-01-18

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： DONE, Susan Jane ,  CAWTHORN, Thomas Richard ,  MORENO, Juan Carlos ,  EVANS, Kenneth Robert ,  CHEN, Jian ,  ACKLOO, Suzanne Zobeeda

IPC: G01N33/48 ,  A61K31/138 ,  A61P35/00 ,  C12Q1/68 ,  G01N33/483 ,  G01N33/574 ,  G01N33/577 ,  G01N33/68 ,  C40B30/04

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158 ,  G01N33/57415 ,  G01N2800/52

Abstract: Described is a method of providing a prognosis for a subject having or suspected of having breast cancer by determining the level of one or more biomarkers in a test sample. A difference or similarity in the level of one or more biomarkers in the test sample with a control is used to provide a prognosis for the test subject. Also described are methods of identifying a subject with breast cancer who is responsive to hormone treatment. Optionally, the biomarkers include Decorin (DCN) and/or Endoplasmin (HSP90B1). Also described are kits and compositions that include biomarker-specific detection agents useful for performing the methods described herein.

Abstract translation: 描述了通过确定测试样品中一种或多种生物标志物的水平来为具有或怀疑患有乳腺癌的受试者提供预后的方法。 使用具有对照的测试样品中的一种或多种生物标志物的水平的差异或相似性用于为测试对象提供预后。 还描述了鉴定对激素治疗有反应的乳腺癌患者的方法。 任选地，生物标志物包括Decorin（DCN）和/或内啡肽（HSP90B1）。 还描述了包含可用于执行本文所述方法的生物标志物特异性检测剂的试剂盒和组合物。

公开(公告)号：WO2013082702A1

公开(公告)日：2013-06-13

申请号：PCT/CA2012/001122

申请日：2012-12-05

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： ZHENG, Gang ,  LOVELL, Jonathan ,  HUYNH, Elizabeth

IPC: C12Q1/68 ,  B01J13/02 ,  C12N11/04 ,  C12P1/00 ,  C12Q1/00 ,  C12N15/88

CPC classification number: C12Q1/6806 ,  A61K41/0028 ,  B01J13/02 ,  C12N11/04 ,  C12N13/00 ,  C12N15/88 ,  C12P1/00 ,  G01N1/28 ,  Y10T436/143333

Abstract: There is provided herein vesicles comprising a bilayer comprising porphyrin-phospholipid conjugate, wherein the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipids, wherein the vesicle is 1-100 microns in diameter.

Abstract translation: 提供了包含包含卟啉 - 磷脂缀合物的双层的囊泡，其中卟啉 - 磷脂缀合物包含共价连接到脂质侧链上的卟啉，卟啉衍生物或卟啉类似物，优选在sn-1或sn-2位， 的一种磷脂，其中囊泡的直径为1-100微米。

公开(公告)号：WO2012109732A1

公开(公告)日：2012-08-23

申请号：PCT/CA2012/000124

申请日：2012-02-16

Applicant: UNIVERSITY HEALTH NETWORK ,  LIU, Mingyao ,  FUNG, Shan-Yu ,  KESHAVJEE, Shaf

Inventor： LIU, Mingyao ,  FUNG, Shan-Yu ,  KESHAVJEE, Shaf

IPC: A61K47/42 ,  A61K31/519 ,  A61K47/18

CPC classification number: A61K31/519 ,  A61K9/0019 ,  A61K9/0073 ,  A61K9/10 ,  A61K47/183 ,  A61K47/42

Abstract: The present disclosure relates to 4-amino-5-(4-methylphenyl)-7-(t-butyl)pyrazolo[3,4-d]-pyrimidine ("PP1") or (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine ("PP2") drug vehicles comprising a self-assembling peptide in combination with a single amino acid, pharmaceutical compositions comprising PP1 or PP2 and the vehicle and methods and uses thereof.

Abstract translation: 本公开涉及4-氨基-5-（4-甲基苯基）-7-（叔丁基）吡唑并[3,4-d] - 嘧啶（“PP1”）或（4-氨基-5-（4- 氯苯基）-7-（叔丁基）吡唑并[3,4-d]嘧啶（“PP2”）药物载体，其包含与单一氨基酸组合的自组装肽，包含PP1或PP2的药物组合物， 方法和用途。

公开(公告)号：WO2012100339A1

公开(公告)日：2012-08-02

申请号：PCT/CA2012/000078

申请日：2012-01-27

Applicant: UNIVERSITY HEALTH NETWORK ,  DIAMANDIS, Eleftherios P. ,  MAKAWITA, Shalini

Inventor： DIAMANDIS, Eleftherios P. ,  MAKAWITA, Shalini

IPC: G01N33/48 ,  G01N33/574 ,  G01N33/68

CPC classification number: G01N33/57438 ,  G01N2800/52 ,  G01N2800/56

Abstract: The disclosure includes a method of screening for, diagnosing or detecting pancreatic cancer in a subject, the method comprising: a. determining a level of one or more biomarkers in a sample from the subject, wherein the biomarker(s) is/are selected from the proteins listed in any one of Tables 1 to 4, 7-13, and b. comparing the level of each biomarker in the sample with a control; wherein an increased level of any one of the biomarkers compared to the control is indicative that the subject has pancreatic cancer.

Abstract translation: 本公开包括筛选，诊断或检测受试者中胰腺癌的方法，所述方法包括：a。 确定来自所述受试者的样品中的一种或多种生物标志物的水平，其中所述生物标志物选自表1至4，7-13中任一项所列的蛋白质，和b。 将样品中每个生物标志物的水平与对照进行比较; 其中与对照相比任何一种生物标志物的水平升高表明受试者具有胰腺癌。

公开(公告)号：WO2012045163A1

公开(公告)日：2012-04-12

申请号：PCT/CA2011/001130

申请日：2011-10-06

Applicant: UNIVERSITY HEALTH NETWORK ,  PURDIE, Thomas G. ,  SHARPE, Michael B.

Inventor： PURDIE, Thomas G. ,  SHARPE, Michael B.

IPC: A61N5/00 ,  A61B6/03 ,  A61B5/055

CPC classification number: A61N5/1039 ,  A61N5/103 ,  A61N5/1045 ,  A61N2005/1041 ,  A61N2005/1074

Abstract: Methods and systems for automated treatment planning for radiation therapy are disclosed. Such methods and systems may be useful for treatment planning for intensity-modulate radiotherapy (IMRT). Also provided are user interfaces for automated radiation therapy treatment planning.

Abstract translation: 公开了用于放射治疗的自动治疗计划的方法和系统。 这种方法和系统可用于强度调制放疗（IMRT）的治疗计划。 还提供了用于自动化放射疗法治疗计划的用户界面。

公开(公告)号：WO2012014146A2

公开(公告)日：2012-02-02

申请号：PCT/IB2011/053309

申请日：2011-07-25

Applicant: KONINKLIJKE PHILIPS ELECTRONICS N.V. ,  UNIVERSITY HEALTH NETWORK ,  PEKAR, Vladimir ,  QAZI, Arish Asif

Inventor： PEKAR, Vladimir ,  QAZI, Arish Asif

IPC: G06T7/00

CPC classification number: G06K9/34 ,  G01R33/5608 ,  G06T7/0012 ,  G06T7/143 ,  G06T7/149 ,  G06T2207/10072 ,  G06T2207/10081 ,  G06T2207/10104 ,  G06T2207/10108 ,  G06T2207/10136 ,  G06T2207/20076 ,  G06T2207/20081 ,  G06T2207/30004

Abstract: An imager (10) and a reconstruction processor (12) generate an intensity image (14). A region containing a target volume is identified (20) and limited (24). A classifier (30) operates on the voxels in the limited volume with an enhancement filter to generate an enhanced image, such as an image whose voxel values represent a probability that each voxel is in the target volume. A segmentation processor (40) segments the enhanced image to identify the surface of the target volume to generate a segmented image which is displayed on a monitor (52) or used in a radiation therapy planning system (54).

Abstract translation: 成像器（10）和重建处理器（12）产生强度图像（14）。 包含目标体积的区域被标识（20）并且被限制（24）。 分类器（30）利用增强滤波器以有限体积对体素进行操作以生成增强图像，诸如其体素值表示每个体素在目标体积中的概率的图像。 分割处理器（40）分割增强图像以识别目标体积的表面以生成显示在监视器（52）上或用于放射治疗计划系统（54）中的分割图像。