公开(公告)号：WO1989002925A1

公开(公告)日：1989-04-06

申请号：PCT/US1988003169

申请日：1988-09-20

Applicant: ABBOTT LABORATORIES ,  BATES, Diane, Marian ,  ALEJOS, Michael, A.

Inventor： ABBOTT LABORATORIES

IPC: C12Q01/00

CPC classification number: C12Q1/61 ,  C12Q1/60

Abstract: A method for the simultaneous determination of cholesterol and triglyceride substrates with a single reagent system. The reagent system is reacted with the specimen such that each of the substrates reacts with their respective reactant simultaneously. The change in absorbance or fluorescence of the resulting reaction mixture is measured at a plurality of wavelengths which are characteristic for each of the substrates to be determined. The amount of cholesterol and triglyceride substrates can be determined by either an endpoint or reaction rate measurement. The reagent system comprises an enzyme having cholesterol esterase activity, a chromogenic oxygen acceptor, microperoxidase, and cholesterol oxidase for determination of cholesterol; and lipase, ATP, PEP, glycerol kinase, pyruvate kinase, LDH and NAD(P)H or analogs thereof for determination of triglyceride.

Abstract translation: 用单一试剂系统同时测定胆固醇和甘油三酯底物的方法。 试剂系统与样品反应，使得每个底物同时与其各自的反应物反应。 所得到的反应混合物的吸光度或荧光的变化是在要确定的每个基底的特征的多个波长下测量的。 胆固醇和甘油三酯底物的量可以通过终点或反应速率测量来确定。 试剂系统包括具有胆固醇酯酶活性的酶，显色氧受体，微过氧化物酶和用于测定胆固醇的胆固醇氧化酶; 和脂肪酶，ATP，PEP，甘油激酶，丙酮酸激酶，LDH和NAD（P）H或其类似物以测定甘油三酸酯。

公开(公告)号：WO1985003951A1

公开(公告)日：1985-09-12

申请号：PCT/FR1985000045

申请日：1985-03-07

Applicant: INSTITUT PASTEUR ,  ABBOTT LABORATORIES ,  BRECHOT, Christian ,  TIOLLAIS, Pierre ,  SCOTTO, Jacques ,  KUHNS, Mary

Inventor： INSTITUT PASTEUR ,  ABBOTT LABORATORIES

IPC: C12Q01/70

CPC classification number: C12Q1/706

Abstract: Reagent and method for the quantitative dosing of a viral DNA such as that of hepatitis B. The reagent contains as a mixture on one hand a predetermined concentration of a phage, wherein is packaged a DNA probe which may be hybridized to the viral DNA to be dosed, and on the other hand proteins. The method comprises contacting said reagent with the sample containing the viral DNA to be dosed in conditions enabling hybridation, and comparing the quantities of hybrids formed with a predetermined chart to finally determine the viral DNA concentration of the sample.

公开(公告)号：WO1998030574A1

公开(公告)日：1998-07-16

申请号：PCT/US1997005871

申请日：1997-04-07

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OR, Yat, Sun ,  PHAN, Ly, Tam ,  CHU, Daniel, T. ,  SPINA, Kenneth, P. ,  HALLAS, Robert ,  ELLIOTT, Richard, L. ,  TUFANO, Michael

IPC: C07H17/00

CPC classification number: C07H17/08 ,  C07H17/00

Abstract: Compounds, or pharmaceutically acceptable salts and esters thereof, of formulas: (I); (II); (III); or (IV); wherein A, B, D and E, R , R , and Z specifically defined, having antibacterial activity, pharmaceutical compositions containing said compounds, treatment of bacterial infections with such compositions, and processes for the preparation of the compounds.

Abstract translation: 化合物或其药学上可接受的盐和酯，其具有下式：（I）; （II）; （III）; 或（IV）; 其特征在于具有抗菌活性的A，B，D和E，R 1，R 2和Z，含有所述化合物的药物组合物，用这些组合物治疗细菌感染，以及制备化合物的方法 。

公开(公告)号：WO1998029747A1

公开(公告)日：1998-07-09

申请号：PCT/US1997023767

申请日：1997-12-23

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DAWSON, George, J. ,  DILLE, Bruce, J. ,  GUTIERREZ, Robin, A. ,  MUSHAHWAR, Isa, K.

IPC: G01N33/569

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/109 ,  C07K2319/00 ,  C12N2770/24222 ,  C12Q1/707 ,  G01N33/576

Abstract: Methods for detection of hepatitis GB Virus (HGBV) antigen in test samples. Antibodies to the E2 region of the HGBV are utilized to capture antigen in test samples. Methods include immunoassay and antigen capture polymerase chain reaction. Antibodies are provided which are useful as diagnostic reagents and are provided in test kits.

Abstract translation: 检测样本中肝炎病毒（HGBV）抗原的方法。 用于HGBV的E2区的抗体用于在测试样品中捕获抗原。 方法包括免疫测定和抗原捕获聚合酶链反应。 提供了可用作诊断试剂并在试剂盒中提供的抗体。

公开(公告)号：WO1998028331A2

公开(公告)日：1998-07-02

申请号：PCT/US1997023405

申请日：1997-12-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BRIGGS, Clark, A. ,  GOPALAKRISHNAN, Murali ,  MCKENNA, David, G. ,  MONTEGGIA, Lisa, M. ,  ROCH, Jean-Marc ,  SULLIVAN, James, P. ,  TOUMA, Edward

IPC: C07K14/00

CPC classification number: C07K14/70571 ,  A61K38/00

Abstract: A variant human alpha 7 nicotinic acetylcholine receptor (nAChR) polypeptide is provided wherein the variant contains an amino acid substitution at the valine-274 position of the wild-type human alpha 7 nAChR. Nucleic acid molecules encoding the variant human alpha 7 nAChR, vectors and host cells containing such nucleic acid molecules are also provided. In addition, methods are provided for producing the variant as are methods of using such variants for screening compounds for activity at the nAChR.

Abstract translation: 提供了变体人α7烟碱乙酰胆碱受体（nAChR）多肽，其中变体在野生型人α7nAChR的缬氨酸-274位含有氨基酸取代。 还提供了编码变体人α7nAChR的核酸分子，含有该核酸分子的载体和宿主细胞。 此外，提供了用于产生变体的方法，就是使用这些变体来筛选化合物在nAChR的活性的方法。

公开(公告)号：WO1998025917A1

公开(公告)日：1998-06-18

申请号：PCT/US1997022791

申请日：1997-12-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  OLIVER-SHAFFER, Patricia, A. ,  NARAYANAN, Bikshandarkoil, A. ,  RESEK, James, E. ,  SINGAM, Pulla, R.

IPC: C07D317/60

CPC classification number: C07D405/04 ,  C07D317/60

Abstract: The present invention relates to an asymmetric Michael Addition reaction to produce nitro ketone diasteroisomers with enhanced stereoselectivity.

Abstract translation: 本发明涉及产生具有增强的立体选择性的硝基酮非对映异构体的不对称迈克尔加成反应。

公开(公告)号：WO1998005300A3

公开(公告)日：1998-02-12

申请号：PCT/US1997013626

申请日：1997-08-04

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  FU LU, Mou, Ying ,  ADJEI, Akwete, L. ,  JOHNSON, Hillard, W.

IPC: A61K09/107

公开(公告)号：WO1998004573A1

公开(公告)日：1998-02-05

申请号：PCT/US1997013128

申请日：1997-07-25

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LIU, Jih-Hua ,  RILEY, David, A. ,  SPANTON, Stephen, G.

IPC: C07H17/08

CPC classification number: C07H17/08

Abstract: The present invention concerns the novel antiobiotic 6-O-methylerythromycin A crystal Form I, a process for its preparation, pharmaceutical compositions comprising this compound and a method of use as a therapeutic agent.

Abstract translation: 本发明涉及新型抗生素6-O-甲基红霉素A晶型I，其制备方法，包含该化合物的药物组合物和用作治疗剂的方法。

公开(公告)号：WO1998000565A2

公开(公告)日：1998-01-08

申请号：PCT/US1997010884

申请日：1997-06-23

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  MULLEN, Carolyn, R. ,  SUSTACHEK, Joanne, C.

IPC: C12Q01/68

CPC classification number: C12Q1/689 ,  Y10S435/81

Abstract: Nucleic acid sequences that are useful for detecting Mycoplasma pneumoniae are herein provided. These sequences can be used in hybridization assays or amplification based assays designed to detect the presence of Mycoplasma pneumoniae in a test sample. Additionally, the sequences can be provided as part of a kit.

Abstract translation: 本文提供了可用于检测肺炎支原体的核酸序列。 这些序列可用于设计用于检测测试样品中肺炎支原体存在的杂交测定或基于扩增的测定。 另外，序列可以作为试剂盒的一部分提供。

公开(公告)号：WO1997049982A1

公开(公告)日：1997-12-31

申请号：PCT/US1997009567

申请日：1997-05-29

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  KIM, Young, Ran ,  KIHARA, Jean, Emiko

IPC: G01N15/14

CPC classification number: G01N33/96 ,  G01N15/1459 ,  G01N33/5002 ,  G01N33/5005 ,  G01N2015/1006 ,  G01N2015/1402 ,  Y10T436/10 ,  Y10T436/101666 ,  Y10T436/106664 ,  Y10T436/107497 ,  Y10T436/108331 ,  Y10T436/25125 ,  Y10T436/2525

Abstract: Hematology reference control cells and method of manufacture. The invention relates to the methods of preparing stable white blood cell ("WBC") and nucleated red blood cell ("NRBC") fractions and the hematology control reagents containing such stabilized cells for primary use on a multi-angle light scatter based hematology instrument.

Abstract translation: 血液学参考对照细胞及其制造方法。 本发明涉及制备稳定的白血细胞（“WBC”）和有核红细胞（“NRBC”）级分的方法和含有这种稳定细胞的血液控制试剂，用于多角度光散射基血液仪 。