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    Methods and devices for sample lysis
    131.
    发明授权
    Methods and devices for sample lysis 有权
    样品溶解的方法和装置

    公开(公告)号：US09580679B2

    公开(公告)日：2017-02-28

    申请号：US14033365

    申请日：2013-09-20

    Applicant: California Institute of Technology

    Inventor： Samuel Njoroge ,  John Gorman ,  George Maltezos ,  Axel Scherer

    IPC: C12N1/06 ,  B01L3/00 ,  B01L7/00 ,  C12M1/00 ,  B01J19/24 ,  G01N27/447

    CPC classification number: C12M47/06 ,  B01L3/5027 ,  B01L7/52 ,  B01L2300/1883 ,  C12M21/00 ,  C12N1/06 ,  C12N1/066 ,  G01N27/44791

    Abstract: Disclosed herein are methods and systems for use in preparing a sample. The methods and systems may be used for lysing one or more structures in a sample (e.g., cells, viral particles, etc.). The methods and compositions may comprise a microfluidic chip or use thereof. The microfluidic chips disclosed herein may comprise (a) a substrate comprising a chamber, wherein at least one mechanical element may be located within the chamber; (b) a thermal element in contact with the chamber; and (c) at least one aperture within the surface of the substrate, wherein the aperture may be configured to insulate the chamber.

    Abstract translation: 本文公开了用于制备样品的方法和系统。 方法和系统可用于裂解样品中的一种或多种结构（例如，细胞，病毒颗粒等）。 所述方法和组合物可以包含微流控芯片或其用途。 本文公开的微流体芯片可以包括（a）包括腔室的基底，其中至少一个机械元件可以位于腔室内; （b）与所述室接触的热元件; 以及（c）在所述基底表面内的至少一个孔，其中所述孔可以被配置为使所述腔绝缘。

    Pen-shaped device for biological sample preparation and analysis
    136.
    发明授权
    Pen-shaped device for biological sample preparation and analysis 有权
    用于生物样品制备和分析的笔形装置

    公开(公告)号：US09090891B2

    公开(公告)日：2015-07-28

    申请号：US14070465

    申请日：2013-11-01

    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

    Inventor： Xiomara Linnette Madero ,  Imran R Malik ,  Erika F Garcia ,  Axel Scherer

    IPC: G01N21/75 ,  C12N15/10 ,  F17D3/00

    CPC classification number: C12N15/1017 ,  F17D3/00 ,  G01N21/75 ,  Y10T137/8593

    Abstract: Methods and devices for biological sample preparation and analysis are disclosed. A device may have a circular arrangement of containers, with a connecting structure such as a disk. Fluidics channels between containers allow the performance of different techniques for sample preparation, such as lysing, washing and elution. The device may be pen-shaped and have a sample drawing needle connected to the containers.

    Abstract translation: 公开了用于生物样品制备和分析的方法和装置。 装置可以具有圆形布置的容器，具有诸如盘的连接结构。 容器之间的流体通道允许执行不同的样品制备技术，如裂解，洗涤和洗脱。 该装置可以是笔形的并且具有连接到容器的抽样针。

    SIGNAL ENCODING AND DECODING IN MULTIPLEXED BIOCHEMICAL ASSAYS
    138.
    发明申请
    SIGNAL ENCODING AND DECODING IN MULTIPLEXED BIOCHEMICAL ASSAYS 审中-公开
    多重生物化学测定中的信号编码和解码

    公开(公告)号：US20150057178A1

    公开(公告)日：2015-02-26

    申请号：US14451876

    申请日：2014-08-05

    Applicant: California Institute of Technology

    Inventor： Emil Kartalov ,  Aditya Rajagopal ,  Axel Scherer

    IPC: G06F19/20 ,  C12Q1/68

    CPC classification number: G06F19/20 ,  C12Q1/68 ,  C12Q1/6825 ,  C12Q1/6851 ,  G01N21/6486 ,  G06F17/10 ,  G06F17/11 ,  G06F19/12 ,  G06F19/24 ,  Y02A50/53 ,  C12Q2537/101 ,  C12Q2537/143 ,  C12Q2537/165 ,  C12Q2563/107

    Abstract: This disclosure provides methods, systems, compositions, and kits for the multiplexed detection of a plurality of analytes in a sample. In some examples, this disclosure provides methods, systems, compositions, and kits wherein multiple analytes may be detected in a single sample volume by acquiring a cumulative measurement or measurements of at least one quantifiable component of a signal. In some cases, additional components of a signal, or additional signals (or components thereof) are also quantified. Each signal or component of a signal may be used to construct a coding scheme which can then be used to determine the presence or absence of any analyte.

    Abstract translation: 本公开提供了用于多个检测样品中多个分析物的方法，系统，组合物和试剂盒。 在一些实例中，本公开提供方法，系统，组合物和试剂盒，其中可以通过获取信号的至少一个可定量分量的累积测量或测量，在单个样品体积中检测多个分析物。 在某些情况下，信号的附加组件或附加信号（或其组件）也被量化。 信号的每个信号或分量可以用于构建编码方案，然后可以使用它来确定是否存在任何分析物。

    OPTICAL SENSOR FOR ANALYTE DETECTION
    139.
    发明申请
    OPTICAL SENSOR FOR ANALYTE DETECTION 有权
    用于分析仪检测的光学传感器

    公开(公告)号：US20140099732A1

    公开(公告)日：2014-04-10

    申请号：US14046739

    申请日：2013-10-04

    Applicant: California Institute of Technology

    Inventor： Sameer Sudhir Walavalkar ,  Andrew Peter Homyk ,  William Maxwell Jones ,  Axel Scherer ,  Scott Fraser ,  Thai Viet Truong

    IPC: G01N21/63

    CPC classification number: G01N21/63 ,  G01N21/6428 ,  G01N21/6458 ,  G01N21/648

    Abstract: Devices, systems, and methods for detection of an analyte in a sample are disclosed. In some embodiments, an optical sensor can include a metallic layer and a plurality of dielectric pillars extending through the metallic layer. A plurality of regions of concentrated light can be supported in proximity to the ends of the plurality of dielectric pillars when a surface of the metallic layer is illuminated. Concentrated light within one or more of these regions can interact with an analyte molecule, allowing for detection of the analyte.

    Abstract translation: 公开了用于检测样品中分析物的装置，系统和方法。 在一些实施例中，光学传感器可以包括金属层和延伸穿过金属层的多个介电柱。 当金属层的表面被照亮时，多个集中的光的区域可以被支撑在多个介电柱的端部附近。 一个或多个这些区域内的浓缩光可与分析物分子相互作用，从而允许检测分析物。

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