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    CELL CULTURE SYSTEM
    131.
    发明专利
    CELL CULTURE SYSTEM 未知

    公开(公告)号：SG192931A1

    公开(公告)日：2013-09-30

    申请号：SG2013064126

    申请日：2012-02-28

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  KIM HYUN JUNG

    Abstract: The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.

    CELL CULTURE SYSTEM
    133.
    发明专利
    CELL CULTURE SYSTEM 未知

    公开(公告)号：CA2828110A1

    公开(公告)日：2012-09-07

    申请号：CA2828110

    申请日：2012-02-28

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  KIM HYUN JUNG

    IPC: C12M3/02 ,  C12N1/14 ,  C12N1/20 ,  C12N5/071

    Abstract: The embodiments of the invention described herein relate to systems and methods for culturing and/or maintaining intestinal cells, tissues and/or organoids in vitro. The cells, tissues and/or organoids cultured according to the methods and systems described herein can mimic or reproduce natural intestinal epithelial structures and behavior as well as support co-culture of intestinal microflora.

    Engineered opsonin for pathogen detection and treatment
    134.
    发明专利
    Engineered opsonin for pathogen detection and treatment 未知

    公开(公告)号：AU2011207626A1

    公开(公告)日：2012-08-09

    申请号：AU2011207626

    申请日：2011-01-19

    Applicant: HARVARD COLLEGE

    Inventor： SUPER MICHAEL ,  WAY JEFFREY CHARLES ,  INGBER DONALD E

    IPC: C07K19/00

    Abstract: The present invention provides for engineered molecular opsonins that may be used to bind biological pathogens or identify subclasses or specific pathogen species for use in devices and systems for treatment and diagnosis of patients with infectious diseases, blood-borne infections or sepsis. An aspect of the invention provides for mannose-binding lectin (MBL), which is an abundant natural serum protein that is part of the innate immune system. The ability of this protein lectin to bind to surface molecules on virtually all classes of biopathogens (viruses, bacteria, fungi, protozoans) make engineered forms of MBL extremely useful in diagnosing and treating infectious diseases and sepsis.

    MAGNETIC CAPTURE OF A TARGET FROM A FLUID
    135.
    发明申请
    MAGNETIC CAPTURE OF A TARGET FROM A FLUID 审中-公开
    从流体中捕获一个目标的磁性

    公开(公告)号：WO2016077067A3

    公开(公告)日：2016-07-28

    申请号：PCT/US2015057516

    申请日：2015-10-27

    Applicant: HARVARD COLLEGE

    Inventor： KANG JOO HUN ,  INGBER DONALD E ,  SUPER MICHAEL

    IPC: B03C5/00 ,  B03C1/00

    CPC classification number: B03C1/002 ,  B03C1/01 ,  B03C1/025 ,  B03C1/0332 ,  B03C1/286 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26 ,  C12N1/20

    Abstract: Disclosed herein is an improved method for magnetic capture of target molecules (e.g., microbes) in a fluid. Kits and solid substrates for carrying the method described herein are also provided. In some embodiments, the methods, kits, and solid substrates described herein are optimized for separation and/or detection of microbes and microbe-associated molecular pattern (MAMP) (including, e.g., but not limited to, a cell component of microbes, lipopolysaccharides (LPS), and/or endotoxin).

    Abstract translation: 本文公开了用于磁性捕获流体中的靶分子（例如微生物）的改进方法。 还提供了用于运载本文所述方法的试剂盒和固体基质。 在一些实施方案中，本文所述的方法，试剂盒和固体基质针对微生物和微生物相关分子模式（MAMP）（包括例如但不限于微生物的细胞组分，脂多糖的分离和/ （LPS）和/或内毒素）。

    SELF-ASSEMBLING PEPTIDES, PEPTIDE NANOSTRUCTURES AND USES THEREOF
    136.
    发明申请
    SELF-ASSEMBLING PEPTIDES, PEPTIDE NANOSTRUCTURES AND USES THEREOF 审中-公开
    自组装肽，肽类纳米结构及其用途

    公开(公告)号：WO2014014613A3

    公开(公告)日：2014-05-01

    申请号：PCT/US2013046821

    申请日：2013-06-20

    Applicant: HARVARD COLLEGE

    Inventor： INGBER DONALD E ,  ROBERTS KENNY

    IPC: C07K7/06 ,  C07K7/08 ,  C07K14/00

    CPC classification number: C07K14/78 ,  A61K9/1658 ,  A61K47/48246 ,  A61K47/64 ,  C07K14/001

    Abstract: Provided herein relates to self-assembling peptides and various nanostructures self-assembled from the isolated peptides. In some embodiments, the self-assembling peptides can form a nanostructure, e.g., a nanoparticle or microparticle, for use in various biomedical applications such as drug delivery or tissue engineering. In some embodiments, the nanostructures can comprise an agent, e.g., a biological molecule. The agent can be encapsulated or entrapped in the nanostructures during formation of the nanostructures. Alternatively or additionally, the agent can be integrated directly or indirectly (e.g., via a linker or a conjugation or crosslinking agent) to the self-assembling peptide structure, prior to formation of the nanostructures. In some embodiments where the agent is a peptide-based agent, unitary peptide nanostructures, rather than nanoparticles that are formed and later covalently modified, can be generated.

    Abstract translation: 本文涉及自组装肽和从分离的肽自组装的各种纳米结构。 在一些实施方案中，自组装肽可以形成用于各种生物医学应用如药物递送或组织工程的纳米结构，例如纳米颗粒或微粒。 在一些实施方案中，纳米结构可以包含试剂，例如生物分子。 在形成纳米结构期间，该试剂可被包封或包埋在纳米结构中。 或者或另外，在形成纳米结构之前，可将试剂直接或间接（例如经由接头或共轭或交联剂）整合至自组装肽结构。 在其中试剂是基于肽的试剂的一些实施方案中，可以产生单一肽纳米结构，而不是形成和随后共价修饰的纳米颗粒。

    THERMAL MANAGEMENT OF TRANSPARENT MEDIA
    137.
    发明申请
    THERMAL MANAGEMENT OF TRANSPARENT MEDIA 审中-公开
    透明媒体的热管理

    公开(公告)号：WO2012118956A3

    公开(公告)日：2012-11-08

    申请号：PCT/US2012027253

    申请日：2012-03-01

    Applicant: HARVARD COLLEGE ,  INGBER DONALD E ,  HATTON BENJAMIN D ,  WHEELDON IAN R

    Inventor： INGBER DONALD E ,  HATTON BENJAMIN D ,  WHEELDON IAN R

    IPC: H05B3/84

    CPC classification number: E06B3/6715 ,  E06B3/66323 ,  E06B3/66333 ,  E06B3/6722 ,  F24D17/0015 ,  F24J2/0433 ,  F24J2/20 ,  Y02B10/20 ,  Y02E10/44

    Abstract: A bio-inspired window can be created by applying one or more heat exchange layers to one or more surfaces of a window of a building, boat, vehicle or any other structure. The heat exchange layer can include an interconnected network or array of channels or microchannels that can be used to flow a fluid over the surface of the window. The fluid can be used to heat or cool the surface of the window panel to control the flow of heat across the window and reduce the heating or cooling energy load of building. The fluid can be heated or cooled using the ambient air in the building. The refractive index of the fluid can be adjusted to change of optical transparency properties of the window. In some embodiments, the window can appear nearly as clear as an ordinary panel of glass. In other embodiments, the window can color, block or scatter the incoming light.

    Abstract translation: 可以通过将一个或多个热交换层施加到建筑物，船，车辆或任何其他结构的窗户的一个或多个表面来创建生物启发的窗户。 热交换层可以包括可用于使流体在窗口表面上流动的通道或微通道的互连网络或阵列。 流体可用于加热或冷却窗户面板的表面，以控制跨过窗户的热量流动，并减少建筑物的加热或冷却能量负荷。 流体可以使用建筑物中的环境空气进行加热或冷却。 可以调节流体的折射率以改变窗口的光学透明性。 在一些实施例中，窗口可以看起来像普通的玻璃板几乎一样清楚。 在其他实施例中，窗口可以着色，阻挡或散射入射光。

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