公开(公告)号：WO2004046304A1

公开(公告)日：2004-06-03

申请号：PCT/KR2003/002293

申请日：2003-10-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  CHOI, Kuiwon ,  BAE, Tae Soo ,  KIM, Jung Kyu ,  LEE, Chang Yang

Inventor： CHOI, Kuiwon ,  BAE, Tae Soo ,  KIM, Jung Kyu ,  LEE, Chang Yang

IPC: C12M3/00

CPC classification number: C12M27/10 ,  C12M23/08 ,  C12M23/46 ,  Y10S623/911 ,  Y10S623/917 ,  Y10S623/924

Abstract: A hybrid bioreactor for cell culture is disclosed. To simultaneously apply compressive strain for cell differentiation and shear strain for cell proliferation to cells, the hybrid bioreactor includes a plurality of reactor tube assemblies (100), a compressive strain motor (5), a shear strain motor (25), a lower anchor mount (20) having a plurality of toothed anchors (70) to respectively anchor the lower ends of the reactor tube assemblies (100) to the lower anchor mount (20), a ball screw (90) operated in conjunction with the compressive strain motor (5), an upper anchor mount (60) which engages with the ball screw (90) to vertically move upward and downward and having a plurality of compressive strain anchors (80) to anchor the upper ends of the reactor tube assemblies (100) to the upper anchor mount (60), a power transmission unit to transmit the rotating force of the shear strain motor (25) to the toothed anchors (70).

Abstract translation: 公开了用于细胞培养的杂交生物反应器。 为了同时将细胞分化的压缩应变和细胞增殖的剪切应变施加到细胞，混合生物反应器包括多个反应器管组件（100），压缩应变马达（5），剪切应变马达（25），下锚 安装件（20）具有多个齿形锚固件（70），以将反应器管组件（100）的下端分别锚固到下部锚固件安装件（20）;滚珠丝杠（90），与压缩应变马达 （5），与所述滚珠丝杠（90）接合以垂直向上和向下移动并具有多个压缩应变锚（80）以锚固所述反应器管组件（100）的上端的上锚固支架（60） 到上锚固装置（60），用于将剪切应变马达（25）的旋转力传递到齿形锚杆（70）的动力传递单元。

公开(公告)号：WO2004009075A1

公开(公告)日：2004-01-29

申请号：PCT/KR2003/001427

申请日：2003-07-18

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  CHUNG, Hesson ,  JEONG, Seo-Young ,  KWON, Ick-Chan ,  PARK, Yeong-Taek ,  LEE, In-Hyun ,  YUK, Soon-Hong ,  CHOI, Young-Wook ,  PARK, Jae-Hyung ,  CHUNG, Jin-Wook

Inventor： CHUNG, Hesson ,  JEONG, Seo-Young ,  KWON, Ick-Chan ,  PARK, Yeong-Taek ,  LEE, In-Hyun ,  YUK, Soon-Hong ,  CHOI, Young-Wook ,  PARK, Jae-Hyung ,  CHUNG, Jin-Wook

IPC: A61K31/337

CPC classification number: A61K31/337 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/107 ,  A61K45/06 ,  A61K47/10 ,  A61K47/14 ,  A61K47/44 ,  A61K2300/00

Abstract: The present invention relates to a paclitaxel composition and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4~90% by weight of at least one selected from the monoglycerides, 0.01~90% by weight of at least one oil and 0.01~20% by weight of paclitaxel. Also the present invention relates to a paclitaxel composition including emulsifiers and the preparation methods thereof to solubilize paclitaxel wherein said composition comprises 4~90% by weight of at least one selected from the monoglycerides, 0.01~90% by weight of at least one oil, 0.01~90% by weight of at least one emulsifier and 0.01~20% by weight of paclitaxel. The composition of the present invention is an effective paclitaxel delivery system since the composition solubilizes paclitaxel, does not form aggregates after being dispersed in water, adsorbs well on the intestinal wall, and therefore has high bioavailability.

Abstract translation: 本发明涉及紫杉醇组合物及其制备方法，其中所述组合物包含4〜90重量％的选自单酸甘油酯，0.01〜90重量％的至少一种油和0.01〜20重量％的至少一种 紫杉醇的重量％。 本发明还涉及包含乳化剂的紫杉醇组合物及其制备方法来溶解紫杉醇，其中所述组合物包含4〜90重量％的选自单酸甘油酯，0.01〜90重量％的至少一种油的至少一种， 0.01〜90重量％的至少一种乳化剂和0.01〜20重量％的紫杉醇。 本发明的组合物是有效的紫杉醇递送系统，因为组合物溶解紫杉醇，在分散在水中后不形成聚集体，在肠壁上吸附良好，因此具有高的生物利用度。

公开(公告)号：WO2002064115A1

公开(公告)日：2002-08-22

申请号：PCT/KR2002/000205

申请日：2002-02-08

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  JEONG, Seo-Young ,  KWON, Ick-Chan ,  CHUNG, Hesson

Inventor： JEONG, Seo-Young ,  KWON, Ick-Chan ,  CHUNG, Hesson

IPC: A61K9/107

CPC classification number: A61K9/0095 ,  A61K9/1075 ,  A61K9/4858

Abstract: The present invention relates to a liquid insulin formulation and the preparation method thereof. More particularly, the present invention relates to a liquid and powder formulations comprising a monoglyceride, an emulsifier, organic solvent, insulin and acidic aqueous solution. The present invention relates to the liquid and powder insulin formulations with a higher encapsulation efficiency of insulin, higher bioavailability upon oral administration with higher patient compliance and the preparation method thereof.

Abstract translation: 本发明涉及一种液体胰岛素制剂及其制备方法。 更具体地说，本发明涉及包含单酸甘油酯，乳化剂，有机溶剂，胰岛素和酸性水溶液的液体和粉末制剂。 本发明涉及具有较高胰岛素包封率的液体和粉末胰岛素制剂，口服给药后具有较高的患者依从性的较高生物利用度及其制备方法。

公开(公告)号：WO2002061872A1

公开(公告)日：2002-08-08

申请号：PCT/KR2001/000129

申请日：2001-01-31

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  YUN, Kyung-Suk ,  CHO, Byung-Won ,  CHO, Won-Il ,  KIM, Hyung-Sun ,  KIM, Un-Sek

Inventor： YUN, Kyung-Suk ,  CHO, Byung-Won ,  CHO, Won-Il ,  KIM, Hyung-Sun ,  KIM, Un-Sek

IPC: H01M10/40

CPC classification number: H01M10/052 ,  H01M2/162 ,  H01M2/1653 ,  H01M2/1666 ,  H01M2/1686 ,  H01M6/168 ,  H01M10/0565 ,  H01M10/0585 ,  H01M2300/0085 ,  Y02T10/7011

Abstract: The present invention relates to a multi-layered polymer electrolyte and lithium secondary battery comprising the same, wherein the multi-layered polymer electrolyte comprises: A) a separator layer formed of polymer electrolyte, PP, PE, PVdF or non-woven fabric, wherein the separator layer having two surfaces; B) at least one gelled polymer electrolyte layer located on at least one surface of the separator layer comprising: a) 5-90 wt% of PAN-based polymer; b) 5-80 wt% of at least one polymer selected from PVdF-based polymer and PMMA-based polymer; 5-80 wt% of at least one polymer selected from the group consisting of PVC-based polymer and PVdF-based polymer; and C) organic electrolyte solution in which lithium salt is dissolved in a solvent.

Abstract translation: 本发明涉及包含该多层聚合物电解质的多层聚合物电解质和锂二次电池，其中多层聚合物电解质包括：A）由聚合物电解质，PP，PE，PVdF或无纺布形成的隔离层，其中 所述分隔层具有两个表面; B）位于分离器层的至少一个表面上的至少一个胶凝聚合物电解质层，包括：a）5-90重量％的PAN基聚合物; b）5-80重量％的至少一种选自PVdF基聚合物和PMMA基聚合物的聚合物; 5-80重量％的选自由PVC基聚合物和PVdF基聚合物组成的组中的至少一种聚合物; 和C）其中锂盐溶解在溶剂中的有机电解质溶液。

公开(公告)号：WO1998016239A1

公开(公告)日：1998-04-23

申请号：PCT/KR1997000192

申请日：1997-10-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  BOK, Song, Hae ,  SON, Kwang, Hee ,  JEONG, Tae, Sook ,  KWON, Byoung, Mog ,  KIM, Young, Kook ,  CHOI, Doil ,  KIM, Sung, Uk ,  BAE, Ki, Hwan ,  PARK, Yong, Bok ,  CHOI, Myung, Sook ,  HWANG, Ingyu ,  MOON, Surk, Sik ,  KWON, Yong, Kook ,  AHN, Jung, Ah ,  LEE, Eun, Sook

IPC: A61K35/78

CPC classification number: A61K31/7048 ,  A23L2/52 ,  A23L33/105 ,  A61K31/352

Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of citrus peel extract as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity comprises an effective amount of citrus peel extract.

Abstract translation: 用于抑制哺乳动物中3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶的活性的药物组合物包括有效量的柑橘皮提取物作为活性成分以及药学上可接受的载体，以及用于 抑制3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶活性包括有效量的柑橘皮提取物。

公开(公告)号：WO1997033976A1

公开(公告)日：1997-09-18

申请号：PCT/KR1997000040

申请日：1997-03-14

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  OH, Tae Kwang ,  KIM, Hyung, Kwon ,  BAE, Kyung, Suk ,  PARK, Young, Seo ,  KIM, Young, Ok ,  CHE, Yang, Ung ,  LEE, Dong, Kuu

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

IPC: C12N01/20

CPC classification number: C12Y301/03008 ,  A23K20/189 ,  C12N9/16 ,  C12R1/07 ,  C12Y301/03026

Abstract: This invention relates to a novel phytase produced from novel strain Bacillus sp. DS11 (KCTC 0231BP) and more precisely, to a novel strain Bacillus sp. DS11 and phytase enzyme enhancing the phosphate bioavailability present in grains supplied to monogastric animals.

Abstract translation: 本发明涉及由新型菌株芽孢杆菌属（Bacillus sp。）生产的新型植酸酶。 DS11（KCTC 0231BP），更准确地说，涉及一种新型芽孢杆菌菌株。 DS11和植酸酶增强了提供给单胃动物的谷物中存在的磷酸盐生物利用度。

公开(公告)号：WO1996033293A1

公开(公告)日：1996-10-24

申请号：PCT/KR1996000032

申请日：1996-02-29

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KOH, Seok, Keun ,  JUNG, Hyung, Jin ,  SONG, Seok, Kyun ,  CHOI, Won, Kook ,  YOON, Young, Soo ,  CHO, Jun, Sik

IPC: C23C08/02

CPC classification number: C04B41/009 ,  B29C59/16 ,  B29C2035/0872 ,  C04B41/0027 ,  C04B41/80 ,  C08J7/12 ,  C23C8/02 ,  C23C8/10 ,  C23C8/20 ,  C23C8/24 ,  C23C10/02 ,  D06P5/20 ,  C04B41/4515 ,  C04B41/4529 ,  C04B35/00

Abstract: The present invention relates to a process for modifying a surface of polymer, metal and ceramic which comprises irradiating ion particles with energy, from a predetermined distance (irradiation distance), on said surface, while blowing reactive gas or gases directly on said surface under vacuum condition, to decrease a wetting angle or to increase adhesive strength of the surface, and to polymers, metal or ceramic having surfaces modified by such process.

Abstract translation: 本发明涉及一种改性聚合物，金属和陶瓷表面的方法，其包括在所述表面上从预定距离（照射距离）照射离子颗粒，同时在真空下直接在所述表面上吹入反应性气体或气体 条件，以降低润湿角度或增加表面的粘合强度，以及具有通过这种方法修饰的表面的聚合物，金属或陶瓷。

公开(公告)号：WO1996023523A1

公开(公告)日：1996-08-08

申请号：PCT/KR1995000189

申请日：1995-12-30

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KIM, Seung, Ho ,  LEE, Jin, Young ,  HAN, Moon, Hi

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

IPC: A61K38/54

CPC classification number: A61L24/106 ,  A61K31/133 ,  A61K38/45 ,  A61K38/4833 ,  A61K45/06 ,  A61L2400/04 ,  C12Y207/11001 ,  C12Y304/21005 ,  Y10S514/834 ,  Y10S514/925 ,  A61K2300/00

Abstract: Disclosed herein is a hemostatic composition comprising thrombin, casein kinase-II, and sphingosine or a sphingosine derivative, which shows an excellent hemostatic or hemopexic activity as well as tissue suture activity.

Abstract translation: 本文公开了包含凝血酶，酪蛋白激酶II和鞘氨醇或鞘氨醇衍生物的止血组合物，其显示出优异的止血或血液透性活性以及组织缝合活性。

公开(公告)号：WO1995033473A1

公开(公告)日：1995-12-14

申请号：PCT/KR1995000073

申请日：1995-06-05

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  PYUN, Kwang, Ho ,  CHOI, Inpyo ,  KANG, Hyung, Sik ,  LEE, Jung, Joon ,  KIM, Young, Ho

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

IPC: A61K35/78

CPC classification number: A61K36/59 ,  A61K2300/00

Abstract: Various root extracts of S. tetrandra S. Moore which inhibit the production of interleukin-6, processes for the preparation thereof and pharmaceutical compositions comprising said extracts useful for the treatment of immune diseases caused by the overproduction of interleukin-6.

Abstract translation: 抑制白细胞介素-6产生的S. tetrandra S.Moole的各种根提取物，其制备方法和包含用于治疗由白介素-6的过量产生引起的免疫疾病的所述提取物的药物组合物。

公开(公告)号：WO1995032210A1

公开(公告)日：1995-11-30

申请号：PCT/KR1995000061

申请日：1995-05-22

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  KIM, Joong, Hyup ,  KIM, Sung, Hoon ,  NAM, Ghil, Soo ,  KIM, Ha, Young ,  SON, Hyen, Joo ,  JANG, Eun, Sook

IPC: C07D519/06

CPC classification number: C07D501/00

Abstract: Novel cephalosporin compounds of formula (I) exhibit potent and broad antibiotic activities against Gram-negative and Gram-positive bacteria and various resistant bacteria.

Abstract translation: 式（I）的新型头孢菌素化合物对革兰氏阴性和革兰氏阳性菌和各种抗性细菌表现出有效和广泛的抗生素活性。