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1.发明申请HESPERIDIN AND HESPERETIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 审中-公开作为3-羟基-3-甲基胆碱CoA（HMG-CoA）还原酶抑制剂的HESPERIDIN和HESPERETIN
公开(公告)号：WO1998016220A1
公开(公告)日：1998-04-23
申请号：PCT/KR1997000190
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , BOK, Song, Hae , SON, Kwang, Hee , JEONG, Tae, Sook , KWON, Byoung, Mog , KIM, Young, Kook , CHOI, Doil , KIM, Sung, Uk , BAE, Ki, Hwan , PARK, Yong, Bok , CHOI, Myung, Sook , HWANG, Ingyu , MOON, Surk, Sik , KWON, Yong, Kook , AHN, Jung, Ah , LEE, Eun, Sook
IPC: A61K31/35
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of hesperidin or hesperetin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of hesperidin or hesperetin.
Abstract translation: 用于抑制哺乳动物中3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶的活性的药物组合物包含有效量的橙皮苷或橙皮素作为活性成分以及药学上可接受的载体，以及用于 抑制哺乳动物中的3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶活性包括有效量的橙皮苷或橙皮素。
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2.发明申请CITRUS PEEL EXTRACT AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 审中-公开CITRUS PEEL提取物作为3-羟基-3-甲基胆碱CoA（HMG-CoA）还原酶抑制剂
公开(公告)号：WO1998016239A1
公开(公告)日：1998-04-23
申请号：PCT/KR1997000192
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , BOK, Song, Hae , SON, Kwang, Hee , JEONG, Tae, Sook , KWON, Byoung, Mog , KIM, Young, Kook , CHOI, Doil , KIM, Sung, Uk , BAE, Ki, Hwan , PARK, Yong, Bok , CHOI, Myung, Sook , HWANG, Ingyu , MOON, Surk, Sik , KWON, Yong, Kook , AHN, Jung, Ah , LEE, Eun, Sook
IPC: A61K35/78
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of citrus peel extract as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity comprises an effective amount of citrus peel extract.
Abstract translation: 用于抑制哺乳动物中3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶的活性的药物组合物包括有效量的柑橘皮提取物作为活性成分以及药学上可接受的载体，以及用于 抑制3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶活性包括有效量的柑橘皮提取物。
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3.发明申请NARINGIN AND NARINGENIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 审中-公开NARINGIN和NARINGENIN作为3-羟基-3-甲基胆碱CoA（HMG-CoA）还原酶抑制剂
公开(公告)号：WO1998016221A1
公开(公告)日：1998-04-23
申请号：PCT/KR1997000191
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , BOK, Song, Hae , SON, Kwang, Hee , JEONG, Tae, Sook , KWON, Byoung, Mog , KIM, Young, Kook , CHOI, Doil , KIM, Sung, Uk , BAE, Ki, Hwan , PARK, Yong, Bok , CHOI, Myung, Sook , HWANG, Ingyu , MOON, Surk, Sik , KWON, Yong, Kook , AHN, Jung, Ah , LEE, Eun, Sook
IPC: A61K31/35
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of naringin or naringenin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of naringin or naringenin.
Abstract translation: 用于抑制哺乳动物中3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶的活性的药物组合物包含有效量的作为活性成分的柚皮苷或柚皮苷与药学上可接受的载体，以及用于 抑制哺乳动物中的3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶活性包括有效量的柚皮苷或柚皮素。
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4.发明公开HESPERIDIN AND HESPERETIN AS INHIBITOR OF ACYL COA-CHOLESTEROL-O-ACYLTRANSFERASE, INHIBITOR OFMACROPHAGE-LIPID COMPLEX ACCUMULATION ON THE ARTERIAL WALL AND PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 审中-公开橙皮苷和橙皮素作为酰基COA胆固醇 - 酰基转移酶抑制剂，巨噬细胞脂质复合物对动脉壁的抑制剂;以及用于预防和治疗肝病的
公开(公告)号：EP1063988A1
公开(公告)日：2001-01-03
申请号：EP98951777.6
申请日：1998-10-20
Applicant: Korea Institute of Science and Technology
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang-Kyu , LEE, Chui Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , LEE, Jun Sung , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
IPC: A61K31/35
CPC classification number: A23L2/56 , A23L33/105 , A23V2002/00 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of hesperidin or hesperetin for inhibiting the activity of acyl CoA-cholesterol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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5.发明授权NARINGIN AND NARINGENIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效UND柚皮苷柚皮素对3-羟基-3-甲基辅酶A（HMG-CoA）还原酶缝边
公开(公告)号：EP1014968B1
公开(公告)日：2004-02-18
申请号：EP97944200.1
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of naringin or naringenin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of naringin or naringenin.
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Patent Agency Ranking6.发明公开NARINGIN AND NARINGENIN AS INHIBITOR OF ACYL COA-CHOLESTEROL-O-ACYLTRANSFERASE, INHIBITOR OF MACROPHAGE-LIPID COMPLEX ACCUMULATION ON THE ARTERIAL WALL AND PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 有权柚皮苷柚皮素和AS酰基辅酶A胆固醇-O-酰基转移抑制剂，用作积累AKROPHAG - 脂质复合物对动脉壁的抑制剂;以及用于预防和治疗肝病的
公开(公告)号：EP1032381A1
公开(公告)日：2000-09-06
申请号：EP98951776.8
申请日：1998-10-20
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang Kyu , LEE, Chul Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
CPC classification number: A61K31/7048 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of naringin or naringenin for inhibiting the activity of acyl CoA-cholestrol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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7.发明公开HESPERIDIN AND HESPERETIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效橙皮苷和橙皮AS 3-羟基-3-甲基COA（HMG-CoA）还原酶抑制剂
公开(公告)号：EP0957911A1
公开(公告)日：1999-11-24
申请号：EP97944199.0
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of hesperidin or hesperetin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of hesperidin or hesperetin.
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8.发明授权HESPERIDIN AND HESPERETIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效橙皮苷和橙皮AS 3-羟基-3-甲基COA（HMG-CoA）还原酶抑制剂
公开(公告)号：EP0957911B1
公开(公告)日：2004-03-10
申请号：EP97944199.5
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
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9.发明公开NARINGIN AND NARINGENIN AS 3-HYDROXY-3-METHYLGLUTARYL CoA(HMG-CoA) REDUCTASE INHIBITOR 失效柚皮苷，柚皮素和AS 3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶抑制剂
公开(公告)号：EP1014968A1
公开(公告)日：2000-07-05
申请号：EP97944200.1
申请日：1997-10-13
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , SON, Kwang Hee , JEONG, Tae Sook , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , BAE, Ki Hwan , PARK, Yong Bok , CHOI, Myung Sook , HWANG, Ingyu , MOON, Surk Sik , KWON, Yong Kook , AHN, Jung Ah , LEE, Eun Sook
CPC classification number: A61K31/7048 , A23L2/52 , A23L33/105 , A61K31/352
Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of naringin or naringenin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of naringin or naringenin.
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10.发明授权NARINGIN AND NARINGENIN AS PREVENTIVE OR TREATING AGENT FOR HEPATIC DISEASES 有权柚皮甙柚皮素和预防的手段，肝脏疾病的治疗
公开(公告)号：EP1032381B1
公开(公告)日：2003-09-03
申请号：EP98951776.8
申请日：1998-10-20
Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： BOK, Song Hae , JEONG, Tae Sook , CHOI, Myung Sook , MOON, Surk Sik , KWON, Yong Kook , LEE, Eun Sook , HYUN, Byung Hwa , CHOI, Yang Kyu , LEE, Chul Ho , BAE, Ki Hwan , PARK, Yong Bok , LEE, Jun Sung , SON, Kwang Hee , KWON, Byoung Mog , KIM, Young Kook , CHOI, Doil , KIM, Sung Uk , HWANG, Ingyu , AHN, Jung Ah , PARK, Young Bae , KIM, Hyo Soo , CHOE, Seong Choon
CPC classification number: A61K31/7048 , A23L33/10 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/00 , A61K2300/00 , A23V2250/2116
Abstract: The present invention relates to uses of naringin or naringenin for inhibiting the activity of acyl CoA-cholestrol-o-acyltransferase, inhibiting the accumulation of macrophage-lipid complex on the arterial endothelium, and preventing or treating hepatic diseases in a mammal.
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