公开(公告)号：WO1998016220A1

公开(公告)日：1998-04-23

申请号：PCT/KR1997000190

申请日：1997-10-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  BOK, Song, Hae ,  SON, Kwang, Hee ,  JEONG, Tae, Sook ,  KWON, Byoung, Mog ,  KIM, Young, Kook ,  CHOI, Doil ,  KIM, Sung, Uk ,  BAE, Ki, Hwan ,  PARK, Yong, Bok ,  CHOI, Myung, Sook ,  HWANG, Ingyu ,  MOON, Surk, Sik ,  KWON, Yong, Kook ,  AHN, Jung, Ah ,  LEE, Eun, Sook

IPC: A61K31/35

CPC classification number: A61K31/7048 ,  A23L2/52 ,  A23L33/105 ,  A61K31/352

Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of hesperidin or hesperetin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of hesperidin or hesperetin.

Abstract translation: 用于抑制哺乳动物中3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶的活性的药物组合物包含有效量的橙皮苷或橙皮素作为活性成分以及药学上可接受的载体，以及用于 抑制哺乳动物中的3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶活性包括有效量的橙皮苷或橙皮素。

公开(公告)号：WO1998016239A1

公开(公告)日：1998-04-23

申请号：PCT/KR1997000192

申请日：1997-10-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  BOK, Song, Hae ,  SON, Kwang, Hee ,  JEONG, Tae, Sook ,  KWON, Byoung, Mog ,  KIM, Young, Kook ,  CHOI, Doil ,  KIM, Sung, Uk ,  BAE, Ki, Hwan ,  PARK, Yong, Bok ,  CHOI, Myung, Sook ,  HWANG, Ingyu ,  MOON, Surk, Sik ,  KWON, Yong, Kook ,  AHN, Jung, Ah ,  LEE, Eun, Sook

IPC: A61K35/78

CPC classification number: A61K31/7048 ,  A23L2/52 ,  A23L33/105 ,  A61K31/352

Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of citrus peel extract as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity comprises an effective amount of citrus peel extract.

Abstract translation: 用于抑制哺乳动物中3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶的活性的药物组合物包括有效量的柑橘皮提取物作为活性成分以及药学上可接受的载体，以及用于 抑制3-羟基-3-甲基戊二酰辅酶A（HMG-CoA）还原酶活性包括有效量的柑橘皮提取物。

公开(公告)号：WO1998016221A1

公开(公告)日：1998-04-23

申请号：PCT/KR1997000191

申请日：1997-10-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  BOK, Song, Hae ,  SON, Kwang, Hee ,  JEONG, Tae, Sook ,  KWON, Byoung, Mog ,  KIM, Young, Kook ,  CHOI, Doil ,  KIM, Sung, Uk ,  BAE, Ki, Hwan ,  PARK, Yong, Bok ,  CHOI, Myung, Sook ,  HWANG, Ingyu ,  MOON, Surk, Sik ,  KWON, Yong, Kook ,  AHN, Jung, Ah ,  LEE, Eun, Sook

IPC: A61K31/35

CPC classification number: A61K31/7048 ,  A23L2/52 ,  A23L33/105 ,  A61K31/352

Abstract: A pharmaceutical composition for inhibiting the activity of 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase in mammals comprises an effective amount of naringin or naringenin as an active ingredient together with a pharmaceutically acceptable carrier, and a food or beverage composition for inhibiting the 3-hydroxy-3-methylglutaryl CoA(HMG-CoA) reductase activity in mammals comprises an effective amount of naringin or naringenin.

Abstract translation: 用于抑制哺乳动物中3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶的活性的药物组合物包含有效量的作为活性成分的柚皮苷或柚皮苷与药学上可接受的载体，以及用于 抑制哺乳动物中的3-羟基-3-甲基戊二酰CoA（HMG-CoA）还原酶活性包括有效量的柚皮苷或柚皮素。

公开(公告)号：EP1113791A2

公开(公告)日：2001-07-11

申请号：EP98951778.4

申请日：1998-10-20

Applicant: Korea Institute of Science and Technology

Inventor： BOK, Song, Hae ,  JEONG, Tae, Sook ,  CHOI, Myung, Sook ,  MOON, Surk, Sik ,  KWON, Yong, Kook ,  LEE, Eun, Sook ,  HYUN, Byung, Hwa ,  CHOI, Yang, Kyu ,  LEE, Chul, Ho ,  AHN, Byung, Tae ,  LEE, Sae, Bom ,  BAE, Ki, Hwan ,  PARK, Yong, Bok

IPC: A61K31/35 ,  A61K31/70 ,  A23L2/56

CPC classification number: A61K31/34 ,  Y10S514/866

Abstract: A use of bioflavonoid of formula (I) or a plant extract containing same for lowering the blood glucose level in a mammal.