公开(公告)号：ZA7704255B

公开(公告)日：1978-06-28

申请号：ZA7704255

申请日：1977-07-15

Applicant: HOECHST AG

Inventor： SCHOELKENS B ,  LERCH U ,  TEUFEL H ,  BARTMANN W ,  BECK G

IPC: A61K31/20 ,  A61K31/23 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/72 ,  C07D319/08 ,  C07D333/32 ,  C07D339/06 ,  C07D339/08 ,  C07F9/40 ,  C07C ,  A61K ,  C07D

CPC classification number: C07D317/72 ,  C07C405/00 ,  C07D319/08 ,  C07D339/06 ,  C07F9/4006 ,  C07F9/4018

公开(公告)号：SE7713386L

公开(公告)日：1978-05-26

申请号：SE7713386

申请日：1977-11-25

Applicant: HOECHST AG

Inventor： BARTMANN W ,  LERCH U ,  TEUFEL H ,  SCHOLKENS B ,  BECK G

IPC: A61K31/205 ,  A61K31/22 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D307/02 ,  C07D317/72 ,  C07D319/08 ,  C07D333/32 ,  C07D339/06 ,  C07D339/08 ,  C07D409/06 ,  C07F9/40 ,  C07C177/00

公开(公告)号：SE7708245L

公开(公告)日：1978-01-17

申请号：SE7708245

申请日：1977-07-15

Applicant: HOECHST AG

Inventor： BARTMANN W ,  LERCH U ,  TEUFEL H ,  SCHOLKENS B

IPC: A61K31/20 ,  A61K31/23 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/72 ,  C07D319/08 ,  C07D333/32 ,  C07D339/06 ,  C07D339/08 ,  C07F9/40 ,  C07C177/00

公开(公告)号：DK322077A

公开(公告)日：1978-01-17

申请号：DK322077

申请日：1977-07-15

Applicant: HOECHST AG

Inventor： BARTMANN W ,  LERCH U ,  TEUFEL H ,  SCHOELKENS B ,  BECK G

IPC: C07D339/08 ,  A61K31/19 ,  A61K31/215 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/72 ,  C07D339/06 ,  C07C

Abstract: What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I wherein R1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic radical having from 1 to 8 carbon atoms, or an araliphatic radical having from 7 to 9 carbon atoms, or a physiologically tolerable metal, NH4 or substituted ammonium ion derived from a primary, secondary or tertiary amine; R2 is a linear or branched, saturated or unsaturated aliphatic hydrocarbon radical having from 1 to 8 carbon atoms; R3 is hydrogen or a R4CO group wherein R4 is a hydrogen atom or a linear or branched alkyl group having up to 10 carbon atoms; A is a saturated, linear or branched alkylene group having from 2 to 5 carbon atoms, and a process for the manufacture thereof.

公开(公告)号：ZA766178B

公开(公告)日：1977-09-28

申请号：ZA766178

申请日：1976-10-15

Applicant: HOECHST AG

Inventor： BARTMANN W ,  SEEGER K ,  BECK G ,  LERCH U

IPC: C07C69/73 ,  A61K31/23 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P43/00 ,  C07C51/00 ,  C07C59/46 ,  C07C59/62 ,  C07C59/82 ,  C07C67/00 ,  C07C253/00 ,  C07C255/46 ,  C07C401/00 ,  C07C405/00 ,  C07D307/54 ,  C07D317/30 ,  C07D319/08 ,  C07D333/24 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  A61K ,  C07C ,  C07D

Abstract: Cyclohexane derivs. (I) and their intermediates are new: In the formula one of R1, R2=H the other=hydroxy or together they form oxo; R3=H, 1-6C opt. branched opt. unsatd. aliphatic or cycloaliphatic radical, 7-9C araliphatic radical, a metallic ion, opt. substd. NH4 or a prim., sec. or tert. amine deriv. R4 is 1-10C opt. branched, opt. unsatd. aliphatic hydrocarbyl or 3-7C cycloaliphatic hydrocarbyl each opt. substd. by (a) 1-7C opt. branched, opt. unsatd. alkoxy or alkylthio, (b) phenoxy opt. substd. by 1 or 2 of 1-3C opt. halo substd. alkyl, halo, phenoxy (opt. substd. by halo) or 1-4C alkoxy, (c) furyloxy, thienyl or benyloxy each opt. mono or independently di-substd. by 1-3C opt. halo substd alkyl, halo or 1-4C alkoxy (d) 1 or 2 F atoms, CF3, or CF2-CF3, (e) 3-7C cycloalkyl (f) phenyl, thienyl or furyl each opt. mono- or independently di-substd. by 1-3C opt. halo substd. alkyl, halo or 1-4C alkoxy. R5 is 1-5C alkyl, 2-5C alkenyl or alkynyl or H; n=2, 3 or 4 and A=trans-CH=CH- or -CH2-CH2-. A typical cpd. is 7-3-(3-hydroxy-(E)-1-actene-1-yl cyclohexane-1-one-2-yl-(Z)-4-heptenoic acid.

公开(公告)号：ZA7606178B

公开(公告)日：1977-09-28

申请号：ZA7606178

申请日：1976-10-15

Applicant: HOECHST AG

Inventor： BARTMANN W ,  SEEGER K ,  BECK G ,  LERCH U

IPC: C07C69/73 ,  A61K31/23 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P43/00 ,  C07C51/00 ,  C07C59/46 ,  C07C59/62 ,  C07C59/82 ,  C07C67/00 ,  C07C253/00 ,  C07C255/46 ,  C07C401/00 ,  C07C405/00 ,  C07D307/54 ,  C07D317/30 ,  C07D319/08 ,  C07D333/24 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  A61K ,  C07C ,  C07D

CPC classification number: C07D319/08 ,  C07C405/0066

公开(公告)号：NO764299L

公开(公告)日：1977-06-21

申请号：NO764299

申请日：1976-12-17

Applicant: HOECHST AG

Inventor： LATTRELL R ,  BARTMANN W ,  KAISER J

IPC: C07D209/40 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/06 ,  A61P9/12 ,  C07D209/42 ,  C07D401/12 ,  C07D405/12 ,  C07D

公开(公告)号：SE7614218A

公开(公告)日：1977-06-20

申请号：SE7614218

申请日：1976-12-17

Applicant: HOECHST AG

Inventor： LATTRELL R ,  BARTMANN W ,  KAISER J

IPC: C07D209/40 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P9/06 ,  A61P9/12 ,  C07D209/42 ,  C07D401/12 ,  C07D405/12 ,  C07D209/30

CPC classification number: C07D209/42 ,  Y10S514/821

公开(公告)号：ZA763741B

公开(公告)日：1977-05-25

申请号：ZA763741

申请日：1976-06-23

Applicant: HOECHST AG

Inventor： REUSCHLING D ,  KUEHLEIN K ,  TEIFEL H ,  BECK G ,  LERCH U ,  BARTMANN W ,  SCHOELKENS B ,  KUNSTMANN R

IPC: C07D207/26 ,  C07D207/27 ,  C07D

公开(公告)号：SE7611507L

公开(公告)日：1977-04-17

申请号：SE7611507

申请日：1976-10-15

Applicant: HOECHST AG

Inventor： BARTMANN W ,  BECK G ,  LERCH U ,  SEEGER K

IPC: C07C69/73 ,  A61K31/23 ,  A61K31/34 ,  A61K31/341 ,  A61K31/357 ,  A61K31/38 ,  A61K31/381 ,  A61P43/00 ,  C07C51/00 ,  C07C59/46 ,  C07C59/62 ,  C07C59/82 ,  C07C67/00 ,  C07C253/00 ,  C07C255/46 ,  C07C401/00 ,  C07C405/00 ,  C07D307/54 ,  C07D317/30 ,  C07D319/08 ,  C07D333/24 ,  C07D407/12 ,  C07D409/06 ,  C07D409/14 ,  C07C61/38 ,  C07C177/00

Abstract: Cyclohexane derivs. (I) and their intermediates are new: In the formula one of R1, R2=H the other=hydroxy or together they form oxo; R3=H, 1-6C opt. branched opt. unsatd. aliphatic or cycloaliphatic radical, 7-9C araliphatic radical, a metallic ion, opt. substd. NH4 or a prim., sec. or tert. amine deriv. R4 is 1-10C opt. branched, opt. unsatd. aliphatic hydrocarbyl or 3-7C cycloaliphatic hydrocarbyl each opt. substd. by (a) 1-7C opt. branched, opt. unsatd. alkoxy or alkylthio, (b) phenoxy opt. substd. by 1 or 2 of 1-3C opt. halo substd. alkyl, halo, phenoxy (opt. substd. by halo) or 1-4C alkoxy, (c) furyloxy, thienyl or benyloxy each opt. mono or independently di-substd. by 1-3C opt. halo substd alkyl, halo or 1-4C alkoxy (d) 1 or 2 F atoms, CF3, or CF2-CF3, (e) 3-7C cycloalkyl (f) phenyl, thienyl or furyl each opt. mono- or independently di-substd. by 1-3C opt. halo substd. alkyl, halo or 1-4C alkoxy. R5 is 1-5C alkyl, 2-5C alkenyl or alkynyl or H; n=2, 3 or 4 and A=trans-CH=CH- or -CH2-CH2-. A typical cpd. is 7-3-(3-hydroxy-(E)-1-actene-1-yl cyclohexane-1-one-2-yl-(Z)-4-heptenoic acid.