公开(公告)号：AR029741A1

公开(公告)日：2003-07-16

申请号：ARP000100036

申请日：2000-01-06

Applicant: BASF AG

Inventor： STEINER GERD ,  SCHELLHAAS KURT ,  LUBISCH WILFRIED ,  HOLZENKAMP UTA ,  STARCK DOROTHEA ,  SZABO LASZLO ,  EMLING FRANZ ,  GARCIA-LADONA FRANCISCO ,  HOFMANN HANS-PETER ,  UNGER LILIANE

IPC: C07D275/06 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/502 ,  A61K31/517 ,  A61K31/519 ,  A61K31/522 ,  A61K31/55 ,  A61K31/551 ,  A61P9/10 ,  A61P25/28 ,  C07D401/12 ,  C07D417/12 ,  C07D471/04 ,  A61K31/428 ,  A61K31/469

Abstract: Uso de compuestos heterocíclicos N-sustituidos de formula (1) donde: A representa alquileno C1-10 ramificado o no ramificado, o alquileno C2-10 de cadena recta o ramificada, que por lo menos comprende un grupo Z que está elegido entre O, S, NR8, ciclopropilo, CO2, CHOH, un doble o triple enlace; B representa 4-piperidina, 4-tetrahidro-1,2,3,6-piridina, 4-piperazina o los correspondientes compuestos anulares agrandados por el agregado de un grupo metileno, donde el enlace con A se produce a través de un átomo de N de B; y Ar representa fenilo que, dado el caso, está sustituido por alquilo C1-6 ramificado o no ramificado, O-alquilo C1-6 ramificado o no ramificado, OH, F, Cl, Br, I, trifluorometilo, NR22, CO2R2, ciano o fenilo, tetralina, indano, grupos aromáticos de condensacion superior, como naftaleno que, dado el caso, está sustituido por alquilo C1-4 u O-alquilo C1-4, antraceno o heterociclos aromáticos de 5 o 6 eslabones, de 1 a 2 heteroátomos que, independientemente entre sí, están elegidos entre O y N, que además pueden estar anillados todavía con otros restos aromáticos; la parte cíclica que contiene al Nitrogeno está representada por las estructuras (2) o (3); uno de los dos restos X, Y representa CH2 y el otro NR9; y los sustituyentes R1, R2, R3, R4, R5, R6, R7, R8 y R9 son como se definen en la memoria descriptiva; como también sus sales con ácidos farmacologicamente tolerables, para la profilaxis y la terapia de la isquemia cerebral y la apoplejía.

公开(公告)号：AT239015T

公开(公告)日：2003-05-15

申请号：AT99942792

申请日：1999-07-20

Applicant: BASF AG

Inventor： STEINER GERD ,  HOEGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  JUCHELKA FRIEDER

IPC: A61K31/4184 ,  A61P25/20 ,  A61P25/24 ,  A61P25/30 ,  C07D403/06

Abstract: The invention relates to compounds of formula (1), wherein R , R and R have the meaning cited in the description. The novel substances are suitable for use in disease control.

公开(公告)号：HRP20010472A2

公开(公告)日：2003-04-30

申请号：HRP20010472

申请日：2001-06-21

Applicant: BASF AG

Inventor： MUNSCHAUER RAINER ,  GROSS GERHARD ,  TRAUT MARTIN ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: C07D403/06 ,  A61K31/403 ,  A61K31/4045 ,  A61K31/407 ,  A61K31/4184 ,  A61K31/424 ,  A61K31/427 ,  A61K31/4709 ,  A61K31/505 ,  A61K31/506 ,  A61K31/513 ,  A61K31/517 ,  A61K31/519 ,  A61K31/542 ,  A61P25/00 ,  A61P25/28 ,  A61P25/30 ,  A61P25/36 ,  C07D209/52 ,  C07D407/12 ,  C07D409/12 ,  C07D417/06 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04 ,  A61K31/416 ,  A61K31/428 ,  A61K31/538

Abstract: The invention relates to the use of N-substituted 3-azabicycloalkane derivatives of formula (I), wherein B, R , R and n have the meanings given in the description, for combating diseases of addiction and other diseases of the central nervous system.

公开(公告)号：PL350246A1

公开(公告)日：2002-12-02

申请号：PL35024600

申请日：2000-01-12

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  UNGER LILIANE ,  NEUMANN-SCHULTZ BARBARA ,  BLUMBACH KAI ,  SCHOEBEL DIETMAR

IPC: A61K31/41 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  C07D249/14 ,  A61K31/427 ,  A61K31/436 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/473 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61P3/04 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P15/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  A61P43/00 ,  C07D249/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D491/04 ,  C07D491/052

Abstract: Triazole compounds of the following formulawhere R1, R2, A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to the influence of dopamine D3 ligands.

公开(公告)号：ZA200106585B

公开(公告)日：2002-08-12

申请号：ZA200106585

申请日：2001-08-10

Applicant: BASF AG

Inventor： STARCK DOROTHEA ,  TREIBER HANS-JOERG ,  UNGER LILIANE ,  NEUMANN-SCHULTZ BARBARA ,  BLUMBACH KAI ,  SCHOEBEL DIETMAR

IPC: A61K31/41 ,  A61K31/4196 ,  A61K31/422 ,  C07D249/14 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/436 ,  A61K31/4439 ,  A61K31/4725 ,  A61K31/473 ,  A61K31/496 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61P3/04 ,  A61P9/00 ,  A61P9/10 ,  A61P13/12 ,  A61P15/10 ,  A61P25/00 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/28 ,  A61P25/30 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  A61P43/00 ,  C07D249/12 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/06 ,  C07D405/14 ,  C07D409/04 ,  C07D409/14 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D491/04 ,  C07D491/052 ,  C07D ,  A61K ,  A61P

Abstract: Triazole compounds of the following formulawhere R1, R2, A and B have the meanings given in the description are described. The compounds according to the invention possess a high affinity for the dopamine D3 receptor and can therefore be used for treating diseases which respond to the influence of dopamine D3 ligands.

公开(公告)号：SK8682001A3

公开(公告)日：2002-08-06

申请号：SK8682001

申请日：1999-12-09

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KETTSCHAU GEORG ,  RIECHERS HARTMUT ,  BAUMANN ERNST ,  HERGENRODER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: C07D251/24 ,  A61K31/505 ,  A61K31/506 ,  A61K31/53 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/08 ,  A61P13/12 ,  A61P15/10 ,  A61P35/00 ,  A61P43/00 ,  C07C229/34 ,  C07C233/87 ,  C07C235/52 ,  C07D239/34 ,  C07D251/22 ,  C07D401/12 ,  C07D491/048 ,  C07D239/60

Abstract: The invention relates to carboxylic acid derivatives of formula (I), in which the substituents have the following meanings: R is tetrazol or a group (a); W and Z, can be identical or different and are nitrogen or methine, provided that if W and Z are methine, then Q is nitrogen; X is nitrogen or CR ; Y is nitrogen or CR ; Q is nitrogen or CR , provided that if Q is nitrogen then X is CR and Y is CR ; R and R are identical or different and are possibly substituted phenyl or naphthyl or phenyl or naphthyl which are linked in an ortho position via a direct bond, a methlyene, ethylene or ethenylene group, an oxygen or sulfur atom or a SO2-, NH- or N-alkyl group or possibly substituted C5-C6-cycloalkyl; R is a rest (b) or (c); and R is hydrogen, C1-C4-alkyl. The invention further relates to their preparation and their use as endothelin receptor antagonists. The invention also relates to compounds of formula (II) and a structural fragment of formula (d) in which the rests R , R , R , R and R have the meanings given in claim no. 1 and to their use as structural elements in an endothelin receptor antagonist.

公开(公告)号：BG63632B1

公开(公告)日：2002-07-31

申请号：BG10122197

申请日：1997-02-12

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  HOEGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: C07D409/12 ,  A61K31/40 ,  A61K31/403 ,  A61P25/18 ,  A61P43/00 ,  C07D209/44 ,  C07D209/52 ,  C07D209/90 ,  C07D209/92 ,  C07D403/06

Abstract: The invention relates to new compounds having the formula where A, R1 and n have the meanings given in the description. 4 claims

公开(公告)号：DE59510244D1

公开(公告)日：2002-07-18

申请号：DE59510244

申请日：1995-07-14

Applicant: BASF AG

Inventor： HELLENDAHL BEATE ,  LANSKY ANNEGRET ,  MUNSCHAUER RAINER ,  BIALOJAN SIEGFRIED ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN ,  WICKE KARSTEN ,  DRESCHER KARLA

IPC: C07D239/26 ,  A61K31/505 ,  A61K31/506 ,  A61P25/16 ,  A61P25/24 ,  A61P25/26 ,  C07D239/38 ,  C07D239/46 ,  C07D239/56 ,  C07D239/60 ,  C07D401/00 ,  C07D401/12

Abstract: The present invention relates to the use of pyrimidine compounds of the following formula:wherein R1, R2, R3, A, B and Ar have the meanings indicated in the description. The compounds according to the invention have a high affinity for the dopamine D3 receptor and can therefore be used to treat disorders which respond to dopamine D3 ligands.

公开(公告)号：PL183526B1

公开(公告)日：2002-06-28

申请号：PL31846095

申请日：1995-07-21

Applicant: BASF AG

Inventor： STEINER GERD ,  MUNSCHAUER RAINER ,  HOEGER THOMAS ,  UNGER LILIANE ,  TESCHENDORF HANS-JUERGEN

IPC: C07D401/06 ,  A61K31/40 ,  A61K31/415 ,  A61K31/47 ,  A61K31/505 ,  A61P25/18 ,  A61P43/00 ,  C07D403/06 ,  C07D471/04 ,  C07D513/04

Abstract: PCT No. PCT/EP95/02893 Sec. 371 Date Sep. 18, 1997 Sec. 102(e) Date Sep. 18, 1997 PCT Filed Jul. 21, 1995 PCT Pub. No. WO96/04272 PCT Pub. Date Feb. 15, 1996N-substitued 3-azabicyclo[3.2.0]heptane derivatives of formula (I) in which R1, R2, A, X, Y and Z have the meanings given in the description, their method of preparation and their use as pharmacological agents.

公开(公告)号：NO312674B1

公开(公告)日：2002-06-17

申请号：NO991079

申请日：1999-03-04

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  JANSEN ROLF ,  KLING ANDREAS ,  KLINGE DAGMAR ,  RIECHERS HARTMUT ,  HERGENROEDER STEFAN ,  RASCHACK MANFRED ,  UNGER LILIANE

IPC: A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61P9/04 ,  A61P9/08 ,  A61P9/12 ,  A61P43/00 ,  C07C59/66 ,  C07C69/734 ,  C07D239/34 ,  C07D239/52 ,  C07D239/60 ,  C07D239/70 ,  C07D491/04 ,  C07D491/048 ,  C07D237/34

Abstract: The invention relates to carboxylic acid derivatives of the formula Iwhere the radicals have the meanings stated in the description, and to their use as drugs.