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    POLYVALENT PRESENTER COMBINATORIAL LIBRARIES AND THEIR USES
    151.
    发明申请
    POLYVALENT PRESENTER COMBINATORIAL LIBRARIES AND THEIR USES 审中-公开
    多重演讲者组合图书馆及其用途

    公开(公告)号：WO9847002A3

    公开(公告)日：1999-03-04

    申请号：PCT/US9806963

    申请日：1998-04-09

    Applicant: ADVANCED MEDICINE INC ,  HARVARD COLLEGE

    Inventor： CHOI SEOK-KI ,  MAMMEN MATHAI ,  WHITESIDES GEORGE M ,  GRIFFIN JOHN

    IPC: C07B61/00 ,  C07H15/04 ,  C07H15/08 ,  G01N33/543 ,  A61K47/48

    CPC classification number: C07H15/04 ,  C07H15/08 ,  C40B40/00

    Abstract: The present invention is based, on our viewing of receptor-ligand interactions and polyvalency in a non-conventional, global manner based on an understanding of how a multicomponent polyvalent presenter interacts with a collection of target binding sites. This differs from the conventional manner of viewing such interactions on a more individualistic basis as a plurality of separate uncoupled receptor-ligand interactions. The non-conventional, global manner of viewing receptor-ligand interactions and polyvalency in biological systems has led us to the realization that the polyvalency can be used as a basis, e.g. a primary basis, for rational drug design and further, that polyvalent agents have universal applications for treating many different diseases or conditions. The non-conventional, global manner of viewing receptor-ligand interactions has led us even further to the realization that the choice of a particular ligand based on its individual binding capability need not be the most important parameter in designing a polyvalent drug. For instance, weakly binding ligands can be used in polyvalent presenters of the present invention. Based, in part, on the foregoing, the present invention provides methods for preparing and screening combinatorial libraries, i.e., arrays, of polyvalent presenters. The polyvalent presenters are generally formed by constructing and arranging a plurality of functional group components R3 (e.g., ligands), on a plurality of framework components (e.g. polymeric backbones), thereby forming an array of polyvalent presenters. Once formed, the array of polyvalent presenters can be screened for useful properties, and the polyvalent presenters identified as having useful properties can, in turn, be used to treat a disease or condition.

    ELECTROANALYTICAL DEVICES WITH PINS AND THREAD
    152.
    发明申请
    ELECTROANALYTICAL DEVICES WITH PINS AND THREAD 审中-公开
    带引脚和螺纹的电子器件

    公开(公告)号：WO2017091272A3

    公开(公告)日：2017-08-10

    申请号：PCT/US2016050418

    申请日：2016-09-06

    Applicant: HARVARD COLLEGE

    Inventor： GLAVAN ANA C ,  AINLA ALAR ,  HAMEDI MAHIAR MAX ,  FERNANDEZ-ABEDUL MARIA TERESA ,  WHITESIDES GEORGE M

    IPC: B01L3/00 ,  B01J19/00 ,  B01L9/00 ,  C25B11/00 ,  G01N27/27 ,  G01N27/447

    CPC classification number: H01L31/0264

    Abstract: An electroanalytical device includes a pin set comprising at least two conductive pins for use as working and counter electrodes, wherein the first and second pins are comprised of a head, a shaft and a piercing tip; and a hydrophobic or omniphobic paper substrate, wherein the substrate is shaped to provide at least one recess for holding a liquid, wherein the shafts of two conductive pins traverse the paper substrate to anchor the heads of the two conductive pins on the recess surface. An electroanalytical device can also include at least two conductive pins for use as working and counter electrodes, a thread, serially wound around the shafts of each of the two conductive pins; and a base into which the piercing tip of each of the pins is secured.

    Abstract translation: 一种电分析装置包括一个引脚组，该引脚组包括用作工作电极和反电极的至少两个导电引脚，其中第一和第二引脚由头部，轴和刺穿尖端组成; 以及疏水性或全向性纸基材，其中所述基材成形为提供用于保持液体的至少一个凹部，其中两个导电针的轴横过所述纸基材以将所述两个导电针的头固定在所述凹部表面上。 电分析装置还可以包括用作工作电极和对电极的至少两个导电引脚，所述导电引脚串联缠绕在两个导电引脚中的每一个的轴上; 以及每个销的刺穿尖端固定在其中的基座。

    SYSTEMS AND METHODS FOR ACTUATING SOFT ROBOTIC ACTUATORS
    154.
    发明申请
    SYSTEMS AND METHODS FOR ACTUATING SOFT ROBOTIC ACTUATORS 审中-公开
    用于驱动软机器人执行器的系统和方法

    公开(公告)号：WO2013103412A3

    公开(公告)日：2013-08-29

    申请号：PCT/US2012059226

    申请日：2012-10-08

    Applicant: HARVARD COLLEGE

    Inventor： SHEPHERD ROBERT F ,  NUNES RUI ,  WHITESIDES GEORGE M

    IPC: F15B15/10

    CPC classification number: F15B13/04 ,  B25J9/1075 ,  B25J9/142

    Abstract: Systems and methods for providing a soft robot is provided. In one system, a robotic device includes a flexible body having a fluid chamber, where a portion of the flexible body includes an elastically extensible material and a portion of the flexible body is strain limiting relative to the elastically extensible material. The robotic device can further include a pressurizing inlet in fluid communication with the fluid chamber, and a pressurizing device in fluid communication with the pressurizing inlet, the pressurizing device including a reaction chamber configured to accommodate a gas-producing chemical reaction for providing pressurized gas to the pressurizing inlet.

    Abstract translation: 提供了用于提供软机器人的系统和方法。 在一个系统中，机器人装置包括具有流体腔室的柔性主体，其中柔性主体的一部分包括可弹性延展的材料，并且柔性主体的一部分相对于可弹性延展的材料是应变限制的。 机器人装置可进一步包括与流体室流体连通的加压入口和与加压入口流体连通的加压装置，加压装置包括反应室，反应室构造成适应产生气体的化学反应，以提供加压气体给 加压入口。

    SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION
    156.
    发明申请
    SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION 审中-公开
    通过接触电气组装的系统和方法

    公开(公告)号：WO2008127649A3

    公开(公告)日：2009-06-04

    申请号：PCT/US2008004704

    申请日：2008-04-11

    Applicant: HARVARD COLLEGE ,  WHITESIDES GEORGE M ,  MCCARTY LOGAN S ,  THOMAS SAMUEL W ,  RECHES MEITAL ,  KAUFMAN GEORGE K

    Inventor： WHITESIDES GEORGE M ,  MCCARTY LOGAN S ,  THOMAS SAMUEL W ,  RECHES MEITAL ,  KAUFMAN GEORGE K

    IPC: C08J5/12 ,  B05D1/04 ,  C08J7/00

    CPC classification number: C08J5/12 ,  B05D3/14 ,  B05D7/02 ,  B05D2401/32 ,  C08J7/047 ,  C08J2327/18 ,  C08J2433/12

    Abstract: The present invention generally relates to the charging of materials via contact electrification, including systems and methods of assembly using contact electrification. One aspect of the present invention is directed to systems and methods of identifying and synthesizing nonionic polymeric materials that can be charged using contact electrification. Another aspect of the present invention is directed to methods of localizing charged particles or other materials on such surfaces, for example, in the presence of a controlled humidity environment. Yet another aspect of the present invention is directed to a surface comprising positively and negatively charged regions. Oppositely charged materials may be attracted to those regions. Other aspects of the invention are directed to methods of making, using, and promoting such materials, or kits containing such materials.

    Abstract translation: 本发明一般涉及通过接触带电充电材料，包括使用接触带电装配的系统和组装方法。 本发明的一个方面涉及鉴定和合成可以使用接触带电充电的非离子聚合物材料的系统和方法。 本发明的另一方面涉及将带电粒子或其它材料定位在这些表面上的方法，例如在受控湿度环境的存在下。 本发明的另一方面涉及包括正带电和带负电荷的区域的表面。 对这些区域可能会吸引相反电荷的材料。 本发明的其它方面涉及制造，使用和促进这些材料或包含这种材料的试剂盒的方法。

    PATTERNING OF IONIC POLYMERS
    157.
    发明申请
    PATTERNING OF IONIC POLYMERS 审中-公开
    离子聚合物的构图

    公开(公告)号：WO2008051432A3

    公开(公告)日：2009-04-09

    申请号：PCT/US2007022219

    申请日：2007-10-18

    Applicant: HARVARD COLLEGE ,  LAHAV MICHAL ,  WINKLEMAN ADAM ,  NAROVLYANSKY MAX ,  PEREZ-CASTILLEJOS RAQUEL ,  WEISS EMILY A ,  RODRIGUEZ LEONARD N J ,  WHITESIDES GEORGE M

    Inventor： LAHAV MICHAL ,  WINKLEMAN ADAM ,  NAROVLYANSKY MAX ,  PEREZ-CASTILLEJOS RAQUEL ,  WEISS EMILY A ,  RODRIGUEZ LEONARD N J ,  WHITESIDES GEORGE M

    IPC: G03F7/00

    CPC classification number: G03F7/0002 ,  B82Y10/00 ,  B82Y40/00 ,  Y10T428/24479

    Abstract: In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.

    Abstract translation: 一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。 这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。 在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与 解决方案。 在另一个实施方案中，构图离子型聚合物的方法涉及光刻。 在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。 有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。 例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

    FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS
    158.
    发明申请
    FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
    微流控网络中导电路径，微型计算机和微结构的制造

    公开(公告)号：WO2007061448A3

    公开(公告)日：2008-08-28

    申请号：PCT/US2006019787

    申请日：2006-05-18

    Applicant: HARVARD COLLEGE ,  BRUZEWICZ DEREK A ,  BONCHEVA-BETTEX MILA ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  WEIBEL DOUGLAS B ,  SHEVKOPLYAS SERGEY ,  MARTINEZ ANDRES

    Inventor： BRUZEWICZ DEREK A ,  BONCHEVA-BETTEX MILA ,  WHITESIDES GEORGE M ,  SIEGEL ADAM ,  WEIBEL DOUGLAS B ,  SHEVKOPLYAS SERGEY ,  MARTINEZ ANDRES

    IPC: H05K3/10 ,  B01F13/00 ,  B01L3/00 ,  B29C39/12

    CPC classification number: H05K3/101 ,  B01L3/5027 ,  B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0874 ,  B01L2400/0415 ,  B33Y80/00 ,  H05K1/0272 ,  H05K1/032 ,  H05K3/389 ,  H05K2201/0162 ,  H05K2201/0305 ,  H05K2203/128 ,  Y10T29/49117

    Abstract: Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.

    Abstract translation: 本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。 在某些实施方案中，形成的装置包括通过固化存在于一个或多个微流体通道（这种装置在下文中称为“微溶体”装置）中的液态金属形成的导电通路。 在某些这样的装置中，其中可以在微流体结构的区域之间形成和/或重组电连接; 在一些情况下，所形成的器件/电路可能是柔性的和/或涉及柔性电气部件。 在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。 在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与...相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。 在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。 在某些实施方案中，形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。 本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

    MICROFLUIDIC DETECTOR
    159.
    发明申请
    MICROFLUIDIC DETECTOR 审中-公开
    微流体检测器

    公开(公告)号：WO2008060449A2

    公开(公告)日：2008-05-22

    申请号：PCT/US2007023595

    申请日：2007-11-09

    Applicant: HARVARD COLLEGE ,  BUTTE MANISH J ,  WONG AMY P ,  SHARPE ARLENE H ,  WHITESIDES GEORGE M

    Inventor： BUTTE MANISH J ,  WONG AMY P ,  SHARPE ARLENE H ,  WHITESIDES GEORGE M

    IPC: G01N33/543 ,  G01N33/569

    CPC classification number: G01N33/56972 ,  G01N33/54373 ,  G01N2333/16 ,  G01N2333/70503 ,  G01N2800/24

    Abstract: Articles and methods for determining an analyte indicative of a disease condition are provided. In some embodiments, articles and methods described herein can be used for determining a presence, qualitatively or quantitatively, of a component, such as a particular type of cell, in a fluid sample. In one particular embodiment, a low-cost microfluidic system for rapid detection of T cells is provided. The microfluidic system may use immobilized antibodies and adhesion molecules in a channel to capture T cells from a fluid sample such as a small volume of blood. The captured T cells may be labeled with a metal colloid (e.g., gold nanoparticles) using an antibody specific for the T Cell Receptor (TCR), and metallic silver can be catalytically precipitated onto the cells. The number of T cells captured can be counted and may indicate a disease condition of a patient such as severe combined immune deficiency or human immunodeficiency virus.

    Abstract translation: 提供了用于确定指示疾病状况的分析物的文章和方法。 在一些实施方案中，本文描述的制品和方法可以用于确定流体样品中组分（例如特定类型的细胞）的定性或定量存在。 在一个特定实施例中，提供了用于快速检测T细胞的低成本微流体系统。 微流体系统可以在通道中使用固定的抗体和粘附分子以从流体样本（例如小体积血液）捕获T细胞。 捕获的T细胞可以使用对T细胞受体（TCR）特异性的抗体用金属胶体（例如金纳米颗粒）标记，并且可以将金属银催化沉淀到细胞上。 捕获的T细胞的数量可以被计数，并且可以指示患者的疾病状况，例如严重的联合免疫缺陷或人类免疫缺陷病毒。

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