公开(公告)号：WO2003024927A1

公开(公告)日：2003-03-27

申请号：PCT/JP2002/009226

申请日：2002-09-10

Applicant: 旭化成株式会社 ,  スルタナ アシマ ,  永原 肇 ,  藤井 雄一 ,  鈴木 賢

Inventor： スルタナ アシマ ,  永原 肇 ,  藤井 雄一 ,  鈴木 賢

IPC: C07D201/02

CPC classification number: C07D223/10 ,  B01J21/08 ,  B01J21/12 ,  B01J23/22 ,  B01J23/24 ,  B01J23/28 ,  B01J29/0308 ,  B01J29/035 ,  B01J29/041 ,  B01J29/85 ,  B01J35/1061 ,  C07D201/02 ,  Y02P20/52

Abstract: A process for producing a lactam, characterized by subjecting an alicyclic primary amine to an oxidation reaction in the presence of a catalyst comprising silicon oxide; and the catalyst comprising silicon oxide which is for use in the process.

Abstract translation: 一种制备内酰胺的方法，其特征在于在含氧化硅的催化剂存在下使脂环伯胺进行氧化反应; 并且包含用于该方法的氧化硅的催化剂。

公开(公告)号：WO2002102772A1

公开(公告)日：2002-12-27

申请号：PCT/US2002/019372

申请日：2002-06-17

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： WERPY, Todd ,  FRYE, John, G., Jr. ,  WANG, Yong ,  ZACHER, Alan, H.

IPC: C07D207/26

CPC classification number: C07D207/267 ,  C07D201/02 ,  C07D201/08

Abstract: The present invention provides methods for making N-methylpyrrolidine and analogous compounds via hydrogenation. Novel catalysts for this process, and novel conditions/yields are also described. Other process improvements may include extraction and hydrolysis steps. Some preferred reactions take place in the aqueous phase. Starting materials for making N-methylpyrrolidine may include succinic acid, N-methylsuccinimide, and their analogs.

Abstract translation: 本发明提供了通过氢化制备N-甲基吡咯烷和类似化合物的方法。 还描述了用于该方法的新型催化剂和新的条件/收率。 其他工艺改进可以包括提取和水解步骤。 一些优选的反应发生在水相中。 用于制备N-甲基吡咯烷的原料可包括琥珀酸，N-甲基琥珀酰亚胺及其类似物。

公开(公告)号：WO2002062754A1

公开(公告)日：2002-08-15

申请号：PCT/EP2002/000870

申请日：2002-01-28

Applicant: BASF AKTIENGESELLSCHAFT ,  KLUGE, Michael ,  HILDEBRANDT, Sören ,  WAGNER, Norbert ,  WEHLAGE, Thomas

Inventor： KLUGE, Michael ,  HILDEBRANDT, Sören ,  WAGNER, Norbert ,  WEHLAGE, Thomas

IPC: C07D201/02

CPC classification number: C07D201/02 ,  C07D201/16

Abstract: Verfahren zur Herstellung von N,N'Carbonylbis-ε-caprolactam durch Umsetzung von ε-Caprolactam mit Phosgen in Gegenwart eines Chlorwasserstoff bindenden Mittels in einem inerten organischen Lösungsmittel und Isolierung des Umsetzungsproduktes aus der Produktlösung, wobei die Isolierung die Schritte umfasst: a) gegebenenfalls Abdestillieren eines Teils des organischen Lösungsmittels von der Produklösung; b) Zugabe von Wasser zu der Produktlösung; c) Entfernung des organischen Lösungsmittels durch azeotrope Destillation, gegebenenfalls unter Ersatz des abdestillierten Wassers, wodurch die Produktlösung an organischem Lösungsmittel verarmt; d) Kristallisieren lassen von N,N'-Carbonylbis-ε-caprolactam aus der an organischem Lösungsmittel verarmten Lösung, wobei eine wässrige Suspension von N,N'-Carbonylbis-ε-caprolactam erhalten wird; und e) Abtrennung des Kristallisats.

Abstract translation: 一种用于与光气中的氢氯化物结合剂的存在下制备N，N'Carbonylbis-ε-己内酰胺通过ε-己内酰胺的反应中，从产物溶液中的反应产物的一种惰性有机溶剂和隔离，其中所述隔离包括以下步骤：a）任选地， 蒸馏出从生产溶液中的有机溶剂的至少一部分; b）添加水至产物溶液; C）通过共沸蒸馏除去有机溶剂，任选取代蒸馏水中，耗尽有机溶剂的产物溶液; D）结晶空白的N，N'-羰基双ε-己内酰胺从贫化有机溶剂溶液，其特征在于，N的水性悬浮液，获得N'羰基双ε-己内酰胺; 晶体的和e）的分离。

公开(公告)号：WO1998006694A1

公开(公告)日：1998-02-19

申请号：PCT/US1997014222

申请日：1997-08-13

Applicant: THE DU PONT MERCK PHARMACEUTICAL COMPANY

Inventor： THE DU PONT MERCK PHARMACEUTICAL COMPANY ,  FEVIG, John, Matthew ,  QUAN, Mimi, Lifen

IPC: C07D207/16

CPC classification number: C07D201/02 ,  C07D207/16 ,  C07D207/22 ,  C07D207/48 ,  C07D261/02 ,  C07D401/06 ,  C07D401/12 ,  C07D413/12

Abstract: The present application describes amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof of formula (I), or pharmaceutically acceptable salt forms thereof, wherein one of D and D' may be C(=NH)NH2 and the other H and J and J may be O or CH2, which are useful as inhibitors of factor Xa.

Abstract translation: 本申请描述了式（I）的脒基苯基 - 吡咯烷，吡咯烷和 - 异恶唑烷及其衍生物或其药学上可接受的盐形式，其中D和D'之一可以是C（= NH）NH 2，而另一个H和 J 1和J 2可以是O或CH 2，其可用作因子Xa的抑制剂。

公开(公告)号：EP3411357A1

公开(公告)日：2018-12-12

申请号：EP17702599.6

申请日：2017-01-30

Applicant: BASF SE

Inventor： DEHN, Richard ,  DEHESTANI, Ahmad ,  MASSONNE, Klemens ,  WAGLÖHNER, Steffen ,  TELES, Joaquim Henrique ,  SCHAUB, Thomas ,  BRÜGGEMANN, Till Christian ,  TELLÄCHE HERRANZ, Carlos ,  TRAPP, Oliver ,  WYSOCKI, Jedrzej

IPC: C07D201/02

CPC classification number: C07D201/02

Abstract: The present invention relates to a method for producing C4-C15 lactams, in which a C1-C10 alkyl nitrite is reacted with a C4-C15 cycloalkane and is exposed during the reaction by means of a light-emitting diode. The thus produced C4-C15 cyclohexanone oxime is then further reacted to a C4-C15 lactam, and the formed C1-C10 alcohol is recycled in the production of the C1-C-10 alkyl nitrite.

公开(公告)号：EP2616436B1

公开(公告)日：2018-05-30

申请号：EP11751729.2

申请日：2011-08-16

Applicant: ExxonMobil Chemical Patents Inc.

Inventor： DAKKA, Jihad, M. ,  BENITEZ, Francisco, M. ,  PATEL, Bryan, A. ,  MOZELESKI, Edmund, J.

IPC: C07C407/00 ,  C07C409/14 ,  C07C2/74 ,  C07C13/28 ,  C07C37/08 ,  C07C39/04 ,  C07C45/53 ,  C07C49/403 ,  C07D201/02

CPC classification number: C07C409/14 ,  C07C2/74 ,  C07C37/08 ,  C07C45/32 ,  C07C45/53 ,  C07C51/00 ,  C07C249/04 ,  C07C407/00 ,  C07C2601/14 ,  C07D201/02 ,  C08G69/00 ,  Y02P20/52 ,  C07C13/28 ,  C07C49/403 ,  C07C39/04

Abstract: In a process for oxidizing a feed comprising cyclohexylbenzene, the feed is contacted with oxygen and an oxidation catalyst in a plurality of reaction zones connected in series, the contacting being conducted under conditions being effective to oxidize part of the cyclohexylbenzene in the feed to cyclohexylbenzene hydroperoxide in each reaction zone. At least one of the plurality of reaction zones has a reaction condition that is different from another of the plurality of reaction zones. The different reaction conditions may include one or more of (a) a progressively decreasing temperature and (b) a progressively increasing oxidation catalyst concentration as the feed flows from one reaction zone to subsequent reaction zones in the series.

公开(公告)号：EP2241552A4

公开(公告)日：2011-10-19

申请号：EP09708203

申请日：2009-02-05

Applicant: UNIV NAGOYA NAT UNIV CORP ,  UBE INDUSTRIES

Inventor： ISHIHARA KAZUAKI ,  FUKUDA YASUHISA ,  SUGIMOTO TSUNEMI ,  KUGIMOTO JUNICHI

IPC: C07D201/04 ,  B01J31/02 ,  C07B61/00 ,  C07D201/02 ,  C07D225/02 ,  C07D251/26

CPC classification number: C07D201/02 ,  B01J31/0244 ,  C07D201/04 ,  C07D225/02 ,  C07D251/26 ,  Y02P20/52

Abstract: Process for producing lactam compounds and Beckmann rearrangement catalysts There is provided a catalyst which is highly active, stable and safe and forms less byproducts for a process for producing a lactam, and a production process. A cycloalkylidene-aminoaxy-1,3,5-triazine compound is provided as a Beckmann rearrangement catalyst and/or a reaction starting material in a reaction process for producing a lactam compound.

公开(公告)号：EP2148856A2

公开(公告)日：2010-02-03

申请号：EP08725798.6

申请日：2008-02-20

Applicant: Board of Trustees of Michigan State University

Inventor： FROST, John W.

IPC: C07D201/00 ,  C07D201/02 ,  C07D201/08

CPC classification number: C07D201/00 ,  C07D201/02 ,  C07D201/08 ,  Y02P20/52

Abstract: Catalytic processes for preparing caprolactam, pipecolinic acid, and their derivatives, from lysine or alpha-amino-epsilon-caprolactam starting materials, and products produced thereby. A process for preparing caprolactam or a derivative thereof, the process comprising contacting a reactant comprising lysine or alpha aminocaprolactam with a catalyst and a gas comprising hydrogen gas, in the presence of a solvent. The catalyst may be provided on a support material, such as a transition metal.

公开(公告)号：EP0934265B1

公开(公告)日：2003-01-02

申请号：EP97938270.2

申请日：1997-08-13

Applicant: Bristol-Myers Squibb Pharma Company

Inventor： FEVIG, John, Matthew ,  QUAN, Mimi, Lifen

IPC: C07D207/16 ,  A61K31/40 ,  C07D207/48 ,  C07D401/12 ,  C07D261/02

CPC classification number: C07D201/02 ,  C07D207/16 ,  C07D207/22 ,  C07D207/48 ,  C07D261/02 ,  C07D401/06 ,  C07D401/12 ,  C07D413/12

公开(公告)号：EP0975590A1

公开(公告)日：2000-02-02

申请号：EP98915567.6

申请日：1998-04-14

Applicant: UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

Inventor： MAHER, John, Michael ,  BRYANT, David, Robert ,  HOLLADAY, Johnathan, Eugene ,  EISENSCHMID, Thomas, Carl ,  BRIGGS, John, Robert ,  OLSON, Kurt, Damar

IPC: C07D201/02 ,  C07D201/08 ,  C08G69/14

CPC classification number: C07D201/02 ,  C07C45/49 ,  C07C45/50 ,  C07C45/68 ,  C07C47/19 ,  C07D201/08 ,  C07F9/65744 ,  C08G69/02 ,  C08G69/14 ,  C08G69/36 ,  Y02P20/582

Abstract: This invention relates to a composition commprising (a) epsilon caprolactam and (b) one or more of 5-[4,5-di(3-carboxypropyl)-2-pyridyl]pentanoic acid or salt or amide, 4-[4,5-di(2-carboxypropyl)-2-pyridyl]-2-methylbutanoic acid or salt or amide, 2-[2-(2-carboxybutyl)-5-(1-carboxypropyl)-4-pyridyl]butanoic acid or salt or amide, 5-[3,5-di(3-carboxypropyl)-2-pyridyl]pentanoic acid or salt or amide, 4-[3,5-di(2-carboxypropyl)-2-pyridyl]-2-methylbutanoic acid or salt or amide, 2-[2-(2-carboxybutyl)-5-(1-carboxypropyl)-3-pyridyl]butanoic acid or salt or amide, 5-amino-4-methylpentanamide, 4-amino-3-ethylbutanamide, 5-[4,5-di(4-hydroxybutyl)-2-pyridyl]pentanol, 4-[4,5-di(2-methoxypropyl)-2-pyridyl]-2-methylbutanol, 2-[2-(2-methoxybutyl)-5-(1-methoxypropyl)-4-pyridyl]butanol, 5-[3,5-di(4-hydroxybutyl)-2-pyridyl]pentanol, 4-[3,5-di(2-methoxypropyl)-2-pyridyl]-2-methylbutanol, 2[2-(2-methoxybutyl)-5-(1-methoxypropyl)-3-pyridyl]butanol, 5-amino-4-methyl-1-pentanol, 5-imino-2-methyl-1-pentanamine, 5-amino-2-methyl-1-pentanol, 5-imino-4-methyl-1-pentanamine and 2-butyl-4,5-dipropylpyridine, wherein the weight ratio of component a) to component b) is at least about 99 to 1. The epsilon caprolactam compositions are useful in the preparation of nylon 6.