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    Methods and systems for supercoiling DNA
    161.
    发明专利
    Methods and systems for supercoiling DNA 未知

    公开(公告)号：NL2020257B1

    公开(公告)日：2019-07-15

    申请号：NL2020257

    申请日：2018-01-09

    Applicant: STICHTING VU

    Inventor： GRAEME ALAN KING ,  FEDERICA BURLA ,  ERWIN JOHANNES GERARD PETERMAN ,  GIJS JAN LODEWIJK WUITE

    IPC: C12N15/63 ,  A61K31/711 ,  C07H21/04 ,  C12N15/10 ,  C12Q1/6806

    Abstract: A method for supercoiling DNA, e.g. negatively supercoiling DNA, is disclosed. In an initial state, at least part of a DNA molecule is torsionally constrained and associated with a first linking number. The at least part of the DNA molecule has a first end connected to a first body and a second end connected to a second body. The method comprises increasing a distance between the first body and the second body for inducing a torque in the at least part of the DNA molecule and for bringing the at least part of the DNA molecule from the initial state into an intermediate state. In the intermediate state the at least part of the DNA molecule is temporarily torsionally unconstrained for at least partially releasing the induced torque for changing, e.g. decreasing, the first linking number. The method further comprises decreasing the distance between the first and second body for bringing the at least part of the DNA molecule from the intermediate state into a further state in which the at least part of the DNA nmlecule is torsionally constrained and associated with a second linking number different from the first linking number.

    Method and system for optical force measurement
    162.
    发明专利
    Method and system for optical force measurement 未知

    公开(公告)号：NL2019937B1

    公开(公告)日：2019-05-24

    申请号：NL2019937

    申请日：2017-11-17

    Applicant: STICHTING VU

    Inventor： GRAEME ALAN KING ,  ANDREAS SEBASTIAN BIEBRICHER ,  ERWIN JOHANNES GERARD PETERMAN ,  IDDO HELLER ,  GIJS JAN LODEWIJK WUITE

    IPC: G01L1/24 ,  G01N15/14 ,  G02B21/00

    Abstract: One aspect of this disclosure relates to a computer- implemented method for determining a force acting on at least 5 part of a structure, for example a biological structure, such as a DNA molecule. The method comprises controlling a light- sensitive system, e.g. of a microscope, to determine light information based on light from the structure. The light is incident on at least a part of the light sensitive system. The 10 light-sensitive system may be said to capture the light from the structure. The at least part of the structure comprises one or more optically active entities, such as DNA intercalator molecules and donor/acceptor fluorophores. At least one of (i) an optical activity of the entities and (ii) 15 a quantity of the entities depends on the force acting on the at least part of the structure. Furthermore, the light information defines a light property value associated with said at least part of the structure. The method further comprises determining the force acting on the at least part of 20 the structure on the basis of said light property value and a reference light property value.

    Holographic metrology apparatus.
    163.
    发明专利
    Holographic metrology apparatus. 未知

    公开(公告)号：NL2021848A

    公开(公告)日：2018-11-06

    申请号：NL2021848

    申请日：2018-10-22

    Applicant: STICHTING VU ,  STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INST ,  UNIV AMSTERDAM ,  ASML NETHERLANDS BV

    Inventor： VASCO TOMAS TENNER ,  JOHANNES FITZGERALD DE BOER ,  ARIE JEFFREY DEN BOEF

    IPC: G03F7/20

    Abstract: A metrology apparatus for determining a characteristic of a structure manufactured on a substrate comprising an illumination branch for illuminating the structure with radiation and a detection branch for guiding a portion of the scattered radiation towards a sensor suitable for recording radiation impinging on the sensor, the detection branch comprising an optical element for capturing a portion of the scattered radiation excluding radiation from the specular reflection, the detection branch further comprising a reception unit for receiving reference radiation being coherent with respect to the radiation that illuminates the structure, the detection branch is configured to guide the reference radiation to the sensor for interfering, on the sensor, with the scattered radiation that is captured by the optical element.

    Method of layered object manufacturing, sheet element, object manufacturing device, and object.
    164.
    发明专利
    Method of layered object manufacturing, sheet element, object manufacturing device, and object. 未知

    公开(公告)号：NL2013687B1

    公开(公告)日：2016-10-04

    申请号：NL2013687

    申请日：2014-10-27

    Applicant: STICHTING VU-VUMC

    Inventor： ERNST JAN BOS

    IPC: B29C67/00

    Abstract: The present invention provides a method of layered object manufacturing using multiple sheet elements each having a predetermined dimension, wherein the sheet elements comprise first interlocking elements configured to interlock with at least a first further sheet element arranged at a first side of the sheet element, and second interlocking elements configured to interlock with at least a second further sheet element arranged at a second side of the sheet element, wherein the second side is opposite the first side. The method comprises stacking the multiple sheet elements on top of each other, wherein the first interlocking elements of a first one of the multiple sheet elements interlock with the second interlocking elements of a second one of the multiple sheet elements arranged at the first side of the first sheet element, and the second interlocking elements interlock with first interlocking elements of a third one of the multiple sheet elements arranged at the second side of the first sheet element. The invention also provides a sheet element, an object manufacturing device, and object constructed with the method.

    UN METODO PARA ANALIZAR UNA MUESTRA DE SANGRE DE UN SUJETO POR LA PRESENCIA DE UN MARCADOR DE ENFERMEDAD.
    169.
    发明专利
    UN METODO PARA ANALIZAR UNA MUESTRA DE SANGRE DE UN SUJETO POR LA PRESENCIA DE UN MARCADOR DE ENFERMEDAD. 未知

    公开(公告)号：MX2013000606A

    公开(公告)日：2013-06-28

    申请号：MX2013000606

    申请日：2011-07-15

    Applicant: STICHTING VU VUMC

    Inventor： WUERDINGER THOMAS ,  NILSSON ROLF JONAS

    IPC: G01N33/48

    Abstract: La presente invención se relaciona con un método para analizar una muestra de sangre de un sujeto por la presencia de un marcador de enfermedad, dicho método comprende los pasos de a) extraer ácido nucleico de las células de sangre enucleadas en la muestra de sangre, para proporcionar una fracción de ácido nucleico extraída de células de sangre enucleadas, y b) analizar la fracción de ácido nucleico extraída de células de sangre enucleadas por la presencia de un marcador de enfermedad, en donde el marcador de enfermedad es una mutación específica de la enfermedad en un gen de una célula del sujeto, o en donde el marcador de enfermedad es un perfil de expresión específico de enfermedad de genes de una célula del sujeto.

    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER
    170.
    发明专利
    A METHOD OF ANALYSING A BLOOD SAMPLE OF A SUBJECT FOR THE PRESENCE OF A DISEASE MARKER 未知

    公开(公告)号：CA2805586A1

    公开(公告)日：2012-01-19

    申请号：CA2805586

    申请日：2011-07-15

    Applicant: STICHTING VU VUMC

    Inventor： WURDINGER THOMAS ,  NILSSON ROLF JONAS

    IPC: G01N33/48

    Abstract: The present invention relates to a method of analysing a blood sample of a subject for the presence of a disease marker, said method comprising the steps of a) extracting nucleic acid from anucleated blood cells in said blood sample to provide an anucleated blood cells-extracted nucleic acid fraction, and b) analysing said anucleated blood cells-extracted nucleic acid fraction for the presence of a disease marker, wherein said disease marker is a disease-specific mutation in a gene of a cell of said subject, or wherein said disease marker is a disease-specific expression profile of genes of a cell of said subject.

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